sex is used as an insult for women “i fucked your mom” “suck my dick” “your mom is whore”,women that have sex are “sluts” while men arent, people refer to sex as “cracked” “used” “smashed” “destroy her holes” and still have the audacy to talk about sex as “intimacy and love”
NEW PREPRINT: Scientists may have found direct evidence that aging is driven by the loss of cellular information, not just the accumulation of damage
For decades we've focused on what aging cells accumulate. This paper focuses on what they lose: Information.
Using a new technology called SeqTag, researchers measured gene expression, chromatin accessibility, and histone modifications in the same aging cells.
What they found was striking: the regulatory systems that tell cells who they are become increasingly out of sync with age. The authors call this "molecular asynchrony."
As cells age, chromatin structure, histone marks, and gene expression begin drifting apart. Regulatory entropy rises. Repressive chromatin erodes. Cells become less certain of their identity and more likely to drift toward alternative fates.
This is what the Information Theory of Aging (ITOA) states: that aging occurs when cells lose epigenetic information, the instructions that tell the genome how to maintain youthful function. DNA may remain largely unchanged, but the system that reads it gradually loses fidelity.
What's remarkable is that this paper doesn't just describe this phenomenon. It quantifies it. The authors measure increasing regulatory entropy, loss of H3K27me3-mediated repression, erosion of heterochromatin, weakening lineage fidelity, and increased cell-fate drift during aging. In progenitor cells, the barriers that normally preserve cellular identity become progressively weaker with age.
Mechanistically, the study argues that aging is associated with increasing molecular asynchrony between chromatin accessibility, H3K27ac/H3K27me3 remodeling, and transcriptional state.
This decoupling is accompanied by increased regulatory entropy, loss of repressive chromatin architecture, and weakening of lineage constraints. Genes affected are those involved in chromatin organization, DNA damage, and Wnt signaling, consistent with ITOA.
Importantly, the authors provide quantitative evidence that age-related heterochromatin erosion lowers the energetic barriers that maintain cell identity, offering a potential mechanistic link between epigenetic information loss, cell-fate drift, and late-life disease susceptibility 👏
On June 9, 2019, an estimated one million Hong Kongers participated in a peaceful march from Victoria Park to the headquarters of the Hong Kong government in opposition to proposed legislation that would have allowed extradition from Hong Kong to mainland China.
This week, we remember the millions of Hong Kongers who peacefully protested against Beijing's broken promise that Hong Kong would maintain a high degree of autonomy from mainland China.
The regime calls them "rioters."
We call them heroes.
🇰🇷🏫University Students Rise Up
South Korea’s youth are furious. Student councils from 12 major universities across the country, including Yonsei University, Seoul National University, and Korea University, announced that they will launch simultaneous picket protests and issue a joint declaration starting tomorrow, June 10.
They emphasized that the right to vote is a fundamental constitutional right and a cornerstone of a democratic republic, condemning the infringement of this right by state institutions as a grave crisis.
"We hereby solemnly declare that we shall not stay silent until the truth is fully disclosed and those responsible are punished to a degree that satisfies the public. We will forever remember this crisis and respond with utmost determination." - Park Ye-eun (Junior, Yeongnam University)