Joseph Powell

Director of Cellular Science @GarvanInstitute | Director of UNSW Cellular Genomics Futures Institute @CellularFutures

[Marios Georgakis @MariosGeorgakis]

This new paper is probably the most prominent example to date of how linking genetic variation to cell-level, rather than tissue-level, gene expression can transform the interpretation of GWAS signals.

The study generates a single-cell eQTL resource from intestinal biopsies and blood samples from 421 individuals, including 125 with inflammatory bowel disease (IBD)👇

[AJHG @AJHGNews]

🧬New from Yazar et al!
📄The impact of sex on the immune system explored at the single-cell level
https://t.co/Qol4b8QJP8

[Jian Yang @jyang1981]

SMR just got a major efficiency upgrade.⚡️Check out the new release here: https://t.co/zmnyKGISbi

[Niko McCarty. @NikoMcCarty]

Announcing "Fast Biology Bounties."

I'm giving away $10,000 for ideas to speed up or reduce costs for wet-lab experiments. I'm looking for ideas that are highly original and technically tractable.

A couple paragraphs will suffice. Supported by Astera Institute. Details below.

[Fabian Theis @fabian_theis]

Join us at Cell Symposia: Single-Cell Biology in the Era of AI (Dec 2–4, 2026, Munich) 🇩🇪

From multi-omics to AI-driven models of cellular dynamics — an exciting lineup across experimental & computational biology.

Hope to see you there!
🔗 https://t.co/bGczW7EYhS

[Joseph Powell @drjosephpowell]

@shyam_lab @SashaGusevPosts Thanks! This is the TenK10K multiome preprint, including single-cell caQTL mapping. https://t.co/hid56iKav1 @anglixue

[Science Advancement and Outreach @SAOscience]

Human pluripotent stem cells allow scientists to model human tissues and organs without using animals, but labeling cell types and states accurately can be tricky.

In this perspective, @twatkeson and colleagues propose a “stem cell-relevant manifold”—a large reference map combining human tissue and stem cell-derived data. This could improve cell annotation, make lab-grown cells more physiologically accurate, and speed insights into development, disease, and potential therapies.

Read in @stemcellreports: https://t.co/lP405Ocr2n

👥 @Elias_RuizMor, @roserventotormo, @drneavin, @drjosephpowell, et al.

🏛️ @GarvanInstitute, @reNEW_Global, @sangerinstitute, @SCICambridge, @CellularFutures

💰 @nhmrc, @reNEW_Global, @wellcometrust

[Joseph Powell @drjosephpowell]

Amplifying for Trainees attending #ASHG25

[Jonathan Pritchard @jkpritch]

I want to try something again at #ASHG25 this year: I'll block some time on Thursday and Friday afternoons to meet with trainees who would be interested to chat on any topic.
I did this last year and it was great to meet a whole bunch of new people, at all career stages!

[Eric Topol @EricTopol]

A new, tour de force review on the future approaches to treat and potentially cure Type 1 diabetes @TheLancet https://t.co/ouS7SPPeqU

[Garvan Institute of Medical Research @GarvanInstitute]

⭐ Congratulations to Dr Albert Henry from Prof Joseph Powell’s lab on being awarded the NSW Health Cardiovascular Research Elite Postdoctoral Researcher Grant. His work combines data science with cardiovascular genetics to identify new therapeutic targets for heart disease.

[Joseph Powell @drjosephpowell]

@dagarfield @dgmacarthur @anglixue It depends on which data you are interested in. Best DM or email us.

[Jake P. Taylor-King @wildtypehuman]

Did a brief interview with @FLGenomics on https://t.co/GggnWgYH4e and our views on what works in single-cell/spatial 'omics! Write up here: https://t.co/trvQBQDeq7

[Human Technopole @humantechnopole]

📢 Up to 10 fully funded PhD scholarships at Human Technopole through @semm_it ! Join our international community & do cutting-edge research in Systems Medicine.

Apply by 9 June 👉 https://t.co/5Ez4BHFHTv #phdlife #phdcareers

[Loïc Yengo @LoicYengo]

Please check out our new manuscript extending the GREML methodology to quantify assortative mating and other forms of trait-associated genetic structures.
Thanks to all our co-authors and the study participants!
Here: https://t.co/DChwBcvmhA

[Decode Science @Decode_Science]

Oz Single Cell Conference is here & we have much to talk about -

@ST_Omics – High-res spatial transcriptomics
@MGI_Technology – Sequencing for precision diagnostics
@ParseBio – High-throughput single-cell profiling

#Genomics #SingleCell #OzSingleCell #EnablingDiscovery

[Hae Kyung Im 任慧耕 임혜경 @hakyim]

Check out our scPrediXcan paper
https://t.co/Pcni6LfrNg
Led by talented @Charles_Zhou12, supervised by @MengjieChen6
and me, with thanks to many contributors

scPrediXcan integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework.

[Element Biosciences @ElemBio]

Heading to Oz Single Cell Sydney @ozsinglecells? Meet Element Biosciences & explore AVITI24™, the first intelligent #multiomics platform. Don’t miss Matthew Kellinger, PhD presentation: "High Dimensional Biology: #SingleCell & Spatial Multiomics Powered by #AVITI24". https://t.co/7LdnRUQjpk
#ozsinglecell25

[Alex Strudwick Young @AlexTISYoung]

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply below. Please repost!

[Joseph Powell @drjosephpowell]

@pdhsu @SashaGusevPosts Shots fired…

[OzSingleCell Omics @ozsinglecells]

Reminder: Early bird registration closes tomorrow! https://t.co/Lr4yULw7G9