the Sai Lab

cryo-ET and enveloped viruses. Principal Investigator @ School of Life Sciences, Tsinghua University, Beijing.

[the Sai Lab @drlisai]

Our work presents the first cryo-ET image of the authentic #Mpox virus and its 3D reconstruction. It's a huge virus. Details in: https://t.co/oNvKCdsbQK

[the Sai Lab @drlisai]

Our new work is online in PNAS today. In this work, electron-beam & PFA inactivated Delta virions were imaged by cryo-ET and compared; homotypic fusion were found between the virions. In situ architecture and membrane fusion of SARS-CoV-2 Delta variant https://t.co/WFHaRcSNJ2

[the Sai Lab @drlisai]

@AMannanBaig @ChlandaL Here is the manuscript, critics welcome.
https://t.co/zq8qHoU54j

[the Sai Lab @drlisai]

@SystemsVirology Here is the manuscript, critics welcome.
https://t.co/zq8qHoD22j

[the Sai Lab @drlisai]

@SystemsVirology We think it is spike related, because the other structural proteins have not mutated much. we proposed a self-fusion theory for the invagination formation (fig 5b), but are open for suggestions

[the Sai Lab @drlisai]

@CVRHutchinson @CeriFielding @ChlandaL Glad you like it.

[the Sai Lab @drlisai]

@ChlandaL Thanks, it's surprising to see a few mutations can change the virus dramatically

[the Sai Lab @drlisai]

@Javier__CB Dear Javier, this is our work, thanks for increasing the publicity of it, so that everyone knows what the virus look like.

[the Sai Lab @drlisai]

Glad to have contributed a figure to this exciting paper on ERGIC. https://t.co/uuM6D6a6Wz

[the Sai Lab @drlisai]

@SchurLab haha, lol on “hype”. Many structural biologists are rushing into ET, but few know how long the learning curve is.

[the Sai Lab @drlisai]

Looking forward to speak at the International conference "#COVID19, Advances and Remaining Challenges", 29 Sep.-1 Oct. 2021, organised by @institutpasteur @PasteurVirology https://t.co/bEnqxiARnD

[the Sai Lab @drlisai]

@dferhadian thanks!

[the Sai Lab @drlisai]

@utokawa Thanks for sharing my work. Are you working in STRUBI or Dunn school?

[the Sai Lab @drlisai]

@GroupZhang @DiamondLightSou @OxfordStrubi Jiwei made it!

[the Sai Lab @drlisai]

I draw Fig.1 to pay tribute to T.Baker and S.Fuller, two pioneer&masters in cryoEM structural virology. S.Fuller was a founder of OPIC @OxfordStrubi, which cultivated #cryoET virology, @BriggsGroup, Guilia and many younger #cryoET generations, including me
https://t.co/8OdzSWHL24

[the Sai Lab @drlisai]

My review is online today on @TrendsBiochem, highlighting the recent advances in in-situ structural virology and cryo-ET method developments. The efforts shed light on the assembly and intracellular activities for some most threatening viruses. https://t.co/8OdzSWHL24

[the Sai Lab @drlisai]

@bengeliscious Hi Ben, 3 hours from the city. Only a fraction of great wall was restored, most, like this piece, were aged. The aged Walls are mostly built on very steep mountains, climbing it is like climbing a cliff

[the Sai Lab @drlisai]

Ancient great wall surrounded by peach flowers, found my peace in the mountains after a week of meetings.

[the Sai Lab @drlisai]

@DrSusanNasif Thanks for liking our work, Susan.