Matthew Blakeley

Structural Biology using X-ray and neutron crystallography.
Responsible for LADI-III & DALI @ILLGrenoble, previously @EMBLGrenoble @OfficialUoM

[Matthew Blakeley @drmpblakeley]

Promising neutron diffraction tests @ILLGrenoble ! 😎

[Matthew Blakeley @drmpblakeley]

Beautiful #neutron diffraction data currently being collected from a crystal of an archetypal radical enzyme using LADI-III @ILLGrenoble

[Matthew Blakeley @drmpblakeley]

@doescience @ORNL @uthsc @NIH @ILLGrenoble Here is one of the #neutron Laue diffraction patterns from the crystal of the Mpro/BBH-1 enzyme-inhibitor complex collected using LADI-III @ILLGrenoble

[DOE Office of Science @doescience]

COVID-19 is still with us. Collaborators @ORNL, @UTHSC, @NIH, & @ILLGrenoble used X-rays and neutrons to gain atomic insights into drugs used to treat COVID-19. It could help open pathways to future treatments: https://t.co/WhcG9a5WQK

[Matthew Blakeley @drmpblakeley]

Neutron diffraction from a microgravity-grown crystal reveals the active site hydrogens of the internal aldimine form of tryptophan synthase @ILLGrenoble @ORNLNeutrons https://t.co/AONVbSadq9

[Matthew Blakeley @drmpblakeley]

Always great to see beautiful neutron diffraction patterns @ILLGrenoble :)

[Matthew Blakeley @drmpblakeley]

@swati_biology @ILLGrenoble @essneutron Here is one of the diffraction patterns from the tests :) @swati_biology @ILLGrenoble @essneutron

[Matthew Blakeley @drmpblakeley]

Revealing protonation states and tracking substrate in serine hydroxymethyltransferase with room-temperature X-ray and neutron crystallography https://t.co/zAEcaCU3kK @ORNLNeutrons @KovalevskyAY @CommsChem @ILLGrenoble

[Matthew Blakeley @drmpblakeley]

Perdeuterated GbpA enables neutron scattering experiments of a lytic polysaccharide monooxygenase https://t.co/tapny71hTt @ACS_Omega @UniOslo @ILLGrenoble @LSG_ILLGrenoble

[Matthew Blakeley @drmpblakeley]

@MartinWalshDLS Congrats Martin! 👏

[Institut Laue-Langevin @ILLGrenoble]

While visiting our facilities, we discussed ILL's #neutron research programme and its challenges for the future.
We pointed out that there are no technological or administrative obstacles to continuing to operate the reactor well beyond 2033 🚀
#Neutrons4Society

2/2

[Matthew Blakeley @drmpblakeley]

Open PhD position in Structural Biology.
NEUTROLECT: Neutron diffraction for deciphering how pathogens interact with human glycolipids.
For more info. please see https://t.co/eYHCw0aDs5
@ILLGrenoble @Cermav_UPR5301 @UGrenobleAlpes @AnneImberty @LukasGajdos2 @LSG_ILLGrenoble

[Matthew Blakeley @drmpblakeley]

Includes an account of how the structure of tryptophan synthase was revealed using neutron diffraction data from crystals grown in microgravity: a journey from Grenoble to space and back again @ChemistryToledo @KovalevskyAY @ORNLNeutrons @ISS_CASIS @ILLGrenoble @LSG_ILLGrenoble

[Neutron Scattering Research Group @NeutronGroup]

@DrLaverty describes the analysis of peptide hydrogel drug delivery using small angle neutron scattering (SANS)
@essneutron @ILLGrenoble
#jointILLESSusermeeting2022

[Neutron Scattering Research Group @NeutronGroup]

"Hydrogen. The most important, but the most neglected atom."
#NeutronsForEurope #UserMeeting2022
@ILLGrenoble @essneutron

[LINXS @LINXS_Sweden]

@LukasGajdos2 presenting results at the @essneutron/@ILLGrenoble users' meeting from his PhD work on a fucose-binding lectin carried out in @LSG_ILLGrenoble and using the LADI-III diffractometer @drmpblakeley. https://t.co/vrGgilobZN

[Matthew Blakeley @drmpblakeley]

Here is one of the #neutron Laue diffraction patterns collected from a crystal of aspartate aminotransferase/pyridoxamine 5'-phosphate using LADI-III @ILLGrenoble

[Matthew Blakeley @drmpblakeley]

An N⋯H⋯N low-barrier hydrogen bond preorganizes the catalytic site of aspartate aminotransferase to facilitate the second half-reaction @ILLGrenoble @KovalevskyAY @ORNLNeutrons @ChemistryToledo @ChemicalScience https://t.co/VSdCL12Niq

[Matthew Blakeley @drmpblakeley]

@AnneImberty Congratulations Anne, fantastic news and thoroughly deserved!

[Lukas Gajdos @LukasGajdos2]

I am extremely happy and honoured to be awarded the Bertaut Prize! Thank you so much! A huge thank you to my great supervisors @AnneImberty @drmpblakeley @vtforsyth and Juliette Devos who supported and guided me in those beautiful PhD years! Thank you all! We will celebrate🥳🕺