Okie dokie, so I was asked many questions about how the mucosal immune system works recently so here's a thread all about that. Because of length, I have put most of the text in slides and tweets will be used to link the relevant sources🧵
Random non-random Friday thoughts: One of the nice things about working in a field where so many have made critical contributions is that I am under no illusions that my presence or eminence is required for the field to exist or thrive. In fact, I find this to be very reassuring.
New paper by @PenteluteLab today in @CommsChem on Rapid de novo discovery of peptidomimetic affinity reagents for human angiotensin converting enzyme 2. Read more here: https://t.co/XGkMfT30Am
Super fun collab with @mike_wuo. We image mycobacteria treated w/ a mycolic acid integration probe and see antibiotic-mediated ejection of cell membrane. Different drugs induce secretory vesicles with different morphology and immunomodulatory effects on macrophages #tuberculosis
Phenotypic assays are powerful yet rarely report on the nuances of bacterial life cycle perturbation. We developed a chemical reporter of mycobacterial cell division and used it to understand antibiotic action. https://t.co/N2bln83iMh.
Fun collaboration spearheaded by @mike_wuo with @ericrubinlab the Hung group @broadinstitute, and the Garner group (@fleshball) to image the mycobacterial lipids #TB in the presence of #antibiotics (Rifampicin results in outer membrane vesicles below). https://t.co/awGkMtaS8v
WOO for Wuo!🎊 @mike_wuo et al design a new probe to discover how the mycobacterial cell wall rearranges itself in the presence of antibiotics. Why won't the lipid bilayer just let these antibiotics in?? Find out here: https://t.co/RrDy2v5019