Siling Du

Neuroimmu-enthusiast🧐GR6 IMM student in the Kipnis lab & Colonna lab at WashU| Studying brain macrophages & neurodegeneration | Re-tweet to learn

[Siling Du @DuSiling]

@VillarVesga Thanks Juan 😆

[Siling Du @DuSiling]

Very thrilled and grateful to see our work featured on the cover of @NeuroCellPress! Many thanks to our co-authors and collaborators who contributed to this study.

[Jonathan Kipnis 🟦 @jonykipnis]

https://t.co/QQS4yRjlJ5 On the cover: In this issue of Neuron, Du et al. @DuSiling show that repeated microglial depletion enables peripheral monocytes from both the blood and skull bone marrow to infiltrate the brain and engraft as monocyte-derived macrophages with distinct identities. Inspired by a passage from the Zuo Zhuan (“The first beat of the drum rouses the soldiers’ spirits; the second weakens their resolve; by the third, they are exhausted”), the artwork depicts three rounds of microglial depletion gradually exhausting the endogenous microglial niche. The two advancing armies represent distinct peripheral sources of invading cells: one arriving from the blood, illustrated by the army bearing the red flag, and the other emerging from the skull bone marrow, portrayed as descending from the mountains. Artist credit: Ying Xu.

[Siling Du @DuSiling]

@GhazalehEsk Thank you Ghazaleh!! :D

[Siling Du @DuSiling]

@juliabelk Thank you Julia :D

[Siling Du @DuSiling]

@lcdsmyth Thanks Leon 😆

[Siling Du @DuSiling]

@NeuroCellPress Special thanks to Ying Xu for turning our rough concept into such a beautiful artwork!

[John Lukens @LukensJohnR]

Decoding the spatiotemporal development of human meninges @CellCellPress https://t.co/9voNl6Hb2q

[Andrea Salvador @amsalvador1]

https://t.co/FpACyIpjS1 -> organ specific ECM shapes identities of intrinsic nervous systems. v cool!

[Juan Villar-Vesga @VillarVesga]

Excited to share our new study out in
@SciImmunology
We show that Monocyte-derived Macrophages drive oxidative damage during neuroinflammation
https://t.co/eGKEMppR9y

[Siling Du @DuSiling]

Congrats Haikuo! Beautiful work!

[Haikuo Li @HaikuoLi]

Check out our recent work on @NatureComms! Greatly appreciate my mentors and collaborators making this possible. We developed epi-Patho-DBiT, a unified platform that enables spatially resolved ATAC -seq or CUT&Tag analyses in FFPE tissues!

[Amy Fan @amycfanphd]

Excited to announce our study (w/ @RukmanThota & @MaxKrummel) published today @Nature:
Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells.

https://t.co/9XENtFrB4h

#immunology #cellbiology @immunox @ucsf

[John Lukens @LukensJohnR]

Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states: Cell https://t.co/BDVimbX4Wu

[Kika @v_moreno_juan]

I am very happy to share that our paper is now published in @Nature 😊
Cell-type-targeted mitochondrial transplantation rescues cell degeneration.
https://t.co/lQACEJLDwg
@IOB_ch (1/6)

[Ya'el Courtney, PhD @ScienceYael]

Just updated my HHMI Gilliam Fellowship application guide for the 2026 competition, which brings major program changes.

Int'l PhD students can now apply. MD-PhDs are eligible. & a new postdoc pathway that can extend HHMI support up to 7 years total.

https://t.co/BSQ11pBpfW

[Jing Chen @JingNeticist]

Giving a talk soon on open box science + microglia taking the road less traveled.

We started with a question about how tissue-resident macrophages develop and ended up uncovering a distinct regulatory program: Maf and Jun drive Zeb2 during primitive hematopoiesis.

[allen institute @AllenInstitute]

The Orange Cat Brain Atlas is here. 🧠🐈

Today, we published the first comprehensive cellular map of the orange cat brain. The new atlas reveals a single, specialized neuron responsible for behaviors like staring at walls, knocking objects off tables, and the 3am "zoomies."

[Takeshi Imai @TakeshiImaiLab]

Our live tissue clearing paper is out in @naturemethods! We achieved optical clearing of mammalian brain tissues without compromising normal neuronal function. Big congrats to @Shigenori774 and our wonderful collaborators! 🎉
https://t.co/joMB5odihK (1/10)

[Siling Du @DuSiling]

@LuLiu_Laura Thank you Lu! And hope our newest version brings more fun to you :D

[Siling Du @DuSiling]

🧵Excited to share my thesis work out today in @NeuroCellPress from @kipnislab and @TheColonnaLab: "Brain-Engrafted Monocyte-derived Macrophages from Blood and Skull-Bone Marrow Exhibit Distinct Properties." 🧠🦴
https://t.co/fNSgDgn6i8

[Siling Du @DuSiling]

@sun_jiameng Thank you Jiameng! 💕

[Siling Du @DuSiling]

@CaoKelei Thank you!!