estebanL

[estebanL @ealopera14]

@INSColombia @incancerologia @UNALOficial @inmegen @fiocruz @INS_Peru @genomicaMX

[estebanL @ealopera14]

🧬 Los biobancos representan una oportunidad para democratizar la ciencia.
Permiten que pacientes y comunidades participen en la investigación y construir medicina basada en nuestras poblaciones.
Infórmate y participa.

#Biobancos #Genómica

[Serena Sanna @serenasanna1]

Proud of @ealopera14 for the great defense and becoming Dr. Lopera 🎉 now you have wings to fly high on your future! Success!

[A.Zhernakova @SashaZhernakova]

What a beautiful birthday present I received today: a thesis book by @ealopera14 on the value of population biobanks in studying complex diseases, with particular focus on @LifelinesNL. Congratulations, @ealopera14 @serenasanna1 @PatrickDeelen @wijmenga_cisca @GroMicrobiome

[estebanL @ealopera14]

@SashaZhernakova @JaviGutierrezA @LifelinesNL @serenasanna1 @PatrickDeelen @wijmenga_cisca @GroMicrobiome yes, of course!!

[estebanL @ealopera14]

@JaviGutierrezA @SashaZhernakova @LifelinesNL @serenasanna1 @PatrickDeelen @wijmenga_cisca @GroMicrobiome Claro Javier!. Con mucho gusto te lo hago llegar. Te escribo en e-mail para que me des tus detalles.

[estebanL @ealopera14]

@claratinta Vieras que todo el mundo aquí esta muy impresionado con el diseño. Todos me preguntan si yo lo hice; y que si les puedo dar el contacto de quien lo hizo. Te toca aprender inglés para comunicarte con lo estudiantes chinos

[estebanL @ealopera14]

5/5 We sincerely thank the biobanks @LifelinesNL and The Netherlands ACM/PLN registry, as well as all the collaborators who made this work possible. @serenasanna1, @PatrickDeelen, @Shuangli1330, @RemcodeBrouwer, @mswertz, @LudeFranke, @wijmenga_cisca, @UMCGgenetica.

[estebanL @ealopera14]

1/5 Why don’t all carriers of the rare PLN:p.Arg14del variant get cardiomyopathy? In our paper we explore the modifiers of this penetrance using the Lifelines general population biobank. https://t.co/yYaJOWJwU6

[estebanL @ealopera14]

4/5 We also found that polygenic prediction of QRS duration is stronger in symptomatic carriers, even when the average polygenic score is similar between the two groups of carriers. Larger genetic datasets are needed to investigate this further.

[Nature Genetics @NatureGenet]

❓Interested in genetic analysis of the #microbiome ?
📰Challenges and future directions for studying effects of host genetics on the gut microbiome
🧑🏿‍🤝‍🧑🏼@serenasanna1 @SashaZhernakova
@A_van_der_graaf @jingyuan_fu @AKurilshikov
⬇️⬇️
https://t.co/VjIt95V6dG
@NatureGenet

[Adriaan @A_van_der_graaf]

Hi everyone,
Today, our paper on microbiome host genetics (🧬) is published in Nature Genetics! 🎉🎉🎉
A 🧵 on what we found with @SashaZhernakova, @serenasanna1, @ealopera14, @AKurilshikov and @Shixian00000

https://t.co/6ks3jufdwl

[Adriaan @A_van_der_graaf]

Today we're sharing an analysis of the genetics behind two important COVID-19 genes: ACE2 and TMPRSS2. A thread on what we have found 1/9
https://t.co/qfqW6gByOf @LifelinesNL @serenasanna1

[Michigan Imputation Server @umimpute]

Looking at panel performance, in samples of African ancestry, imputation is significantly improved over existing panels. 4/

[bioRxiv Evobio @biorxiv_evobio]

Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity https://t.co/LFvkZvvF9z #biorxiv_evobio

[estebanL @ealopera14]

@biorxiv_evobio So the strain in America is not the same as in China. Could this explain why mortality in young (not from a risk group) is apparently more frequent?

[bioRxiv Evobio @biorxiv_evobio]

Positive selection of ORF3a and ORF8 genes drives the evolution of SARS-CoV-2 during the 2020 COVID-19 pandemic https://t.co/ZqTyrXAQim #biorxiv_evobio