Eric

Wanderer of the universe, staring into the abyss.

[Eric @ebrown409]

I feel extremely different in this decade compared to last already. I hope everyone is ready for the bumpy ride, things are probably going to be intense and interesting in the 20's

[Atelier Missor @AtelierMissor_]

“If I had to choose a religion I think I should become a worshipper of the sun. The sun gives to all things life and fertility. It is the true God of the earth.”

— Napoléon Bonaparte

[john gerrard @john__gerrard]

Western Flag (Spindletop, Texas) 2017

[Eric @ebrown409]

I hate to break it to you but you're not monitoring the situation. You're watching the play that is put on for you.

[Eric @ebrown409]

The more money in a prediction market, the more you're willing to pay someone to guarantee the outcome. At some point the market price changes from probability to a bounty. We've invented decentralized mercenaries for the economically powerful.

[Eric @ebrown409]

Imagine the beauty of understanding compressed into such a compact form! Such a beautiful piece!

[Kat ⊷ the Poet Engineer @poetengineer__]

attractor

[Eric @ebrown409]

The US is going to flip or jump sharpy on to a new path in the coming days on a new path that will blow your mind.

[Eric @ebrown409]

The meme of prediction markets replacing delivery doesn't think about the third party that bets no and does everything in his power to prevent the delivery from happening.

[James Lucas @JamesLucasIT]

A book from the 19th century that depicts the Rhine Valley by creating an impression of three-dimensionality and spatial distance.

[Eric @ebrown409]

We have reached peak subjectivity. This is what all bubbles come from, deviation from physical reality. LLMs are dragging people back with ease of access to real information; As compared to the scraps of information, we had due bundle together back in the day. Dangerous times.

[Eric @ebrown409]

This is the start of AI as a religion. Opening an untrained mind to vivid connectivity without a foundation will be a complete shock to systems to make people programmable due to the pure awe of the moment. It's letting you understand in an instant what has been hidden reality.

[Bryan Johnson @bryan_johnson]

First mushroom trip data is out: my brain activity.

Dose: 5 g dried Psilocybe cubensis (B+ strain)
Containing 24.9 mg psilocybin
Psilocybin longevity experiment.

What we see in the brain:

+ brain activity data mirror my subjective experience

+ strong decrease in my brain’s control center (prefrontal + premotor cortex)

+ strong increase in sensory, auditory and speech integration

+ higher entropic brain patterns: open, flexible, less predictable, exploratory

+ brain network patterns resembling a youthful state vs aged and rigid

Matching what I reported experiencing:

+ “felt like my consciousness was dialed up to 10/10.”

+ “I felt hyper aware and hyper alive.”

+ “I experienced sense of touch with awe.”

+ “my mind was insatiably curious and wanted to deploy its sensors into the world and discover all things.”

+ “My brain wanted to stare, study and marvel.”

+ “The flavor exploded in my mouth.”

+ “...restored my perception to youthful levels, returning them to factory settings and dissolving my aged numbness.”

Why this could matter for longevity:

+ In people aged 65-85, higher happiness was linked to a 22% reduced risk of all-cause mortality over 15 years.

+ A meta-analysis showed that optimism correlated with a 35% decrease in heart attacks and a 16% decrease in all-cause mortality.

+ Having a strong purpose in life is associated with a 17% reduction in both heart attacks and all-cause mortality.

+ In psychedelic medicine, treating depression with ketamine has been shown to reverse biological age by up to 3 years.

Together, these findings suggest a plausible mechanism by which psychedelics, including psilocybin, can prolong both health and lifespan by improving mental well-being and rewiring the brain to a more positive, creative, and curious state.

My team and I hypothesized that neuroplasticity, the loosening of rigid inhibitory patterns that makes the brain more flexible, creative, and relaxed, and even the subjective psychedelic state itself may be as meaningful for longevity as methylation shifts, senescence reversal, or telomere biology.

What’s happening mechanistically

Earlier work shows that psilocin (the active metabolite of psilocybin) acts primarily as an agonist at 5-HT₂A serotonin receptors in the cortex. These receptors are especially dense in high-level association and sensory regions, as mapped in a high-resolution PET/MRI atlas of the human serotonin system.

When these receptors are activated, brain imaging studies show an induced state of desynchronization, entropy, and neuroplasticity.  This process erodes the rigid brain hierarchy and default mode networks in favor of a brain-wide spontaneous, creative, curious, and child-like state.

Kernel Flow data shows the same pattern:

The recorded timepoints included:

+ baseline: directly before session start (not shown)
+ timepoint 1: 4 hrs after dose (acute phase effects).
+ timepoint 2: end of the day, before bedtime.
+ timepoint 3: the following morning.

I continue to measure my brain daily.

Image notes
+ The three maps show changes vs. baseline (not absolute activity)

+ Red = increased connectivity, blue = decreased connectivity vs. my baseline.

+ The left reference map shows the 5-HT₂A receptor distribution from PET, the main psilocybin target.

Time Point 1 - 3 hrs post dose

+ Reduced connectivity in the prefrontal and premotor cortex, correlating with acute brain desynchronization.

+ Increased connectivity and hyperintegration between the primary motor and sensory cortex regions.

+ Enhanced connectivity in the auditory and speech areas of the cortex.

+ Inhibited connectivity in the medial prefrontal and posterior zones, areas associated with the Default Mode Network (DMN).

Subjective experience:

+ Enhanced sensory vividness and bodily presence: The brain's top-down hierarchy, originating in the pre-frontal cortex, was attenuated. This reduced predictive filtering, leading to a flood of bottom-up sensory information and heightened bodily perception (e.g., a fascination with water and light dynamics in a jar, a restored, primal joy of touch and sensation).

+ Peak neuroplasticity and cortical entropy: A peak in cortical entropy and neuroplasticity contributed to a feeling of hyperawareness (e.g., heightened sensory perception, feeling "at one with existence," hyper-aware and hyper-alive).

+ Deeper appreciation of music and uninhibited movement and expression: Sharpened auditory senses and reduced top-down inhibition allowed music to be enjoyed on a profound level. Concomitant functional connectivity in speech-motor and auditory-motor integration areas facilitated uninhibited expression through both speech and movement (a restored, uninhibited, child-like joy of music).

+ Note: Full ego dissolution was not experienced, which may necessitate a higher dose to achieve more advanced desynchronization of the prefrontal and parietal cortices.

Time point 2 - 5 hrs post dose, end of trip

+ Intensified sensory and motor hyperconnectivity.

+ Continued increased connectivity in auditory and speech centers, with a relative restoration of connectivity to the speech understanding area.

+ Partial re-emergence of the prefrontal parietal coupling, while prefrontal context remains partially inhibited.

+ Partial re-emergence of connectivity in areas related to the default mode network.

Subjective Experience

+ High-order brain networks begin to restabilize, alongside persisting sensory, motor, auditory, and speech hyperconnectivity, suggesting neuroplasticity in action.

+ The narrative shifts from pure sensation and experience to meaning generation, accompanied by deep philosophical reflection (e.g., reconsidering the meaning of life and one's relationship with mortality in the time of AI, and pondering the future of human evolution).

Time point 3 - next morning (afterglow)

+ Persistence: Patterns from the acute phase continue, including general prefrontal cortex inhibition, ongoing neuronal plasticity, and heightened senses.

+ Intensified connectivity: Increased connectivity is noted in the speech generation area and the somatic sensory association area.

+ DMN inhibition: The default mode network remains inhibited.

Subjective Experience:

+ "Afterglow" effect: Characterized by continued sharpened senses, calm clarity, emotional openness, and low inhibitions. For instance, I felt more comfortable expressing uninhibited, self-deprecating humor (i.e. my post making fun of myself about the insane lengths I go for my Don’t Die experiment)

+ Integration of experience learnings: The heightened activity in the somatic sensory association area aligns with the process of integrating and "making sense" of the raw sensory experience of both the self and the external world.

+ Enhanced creativity: The intensified connectivity in the speech generation area contributed to the uninhibited bout of creative writing I undertook to report my experience.

[pshs04 @pshs04]

And that is what part of Physics was censored

[unusual_whales @unusual_whales]

"Private credit & banking system are sound," Moody's has said.

[Eric @ebrown409]

Economics has always been ambitious cloud of absolute chaos. These piles of money flow around in a limited space until the whole things falls apart. Just look at gold. I see no difference between the Meme Stock Mania and today.

[Eric @ebrown409]

I'm starting to turn on this government being stakeholders in a business deal. What if these companies start to collapse? Is the government going to prop them up to make sure it can keep its investments sound? I can just see bailouts in the future to keep dead companies afloat.

[Eric @ebrown409]

Meme stocks were a covert operation for the public. Tricking you to see the flow of money is the ultimate power. The American public needs to show the world again what it means to be We The People. Speaking as an amplifier for the greatness we need in this world immediately!

[Eric @ebrown409]

The debt is getting called for being puppets of linguistic manipulation. Lazy, money hungry, immoral propagandist that have been breeding like rats have taken control. The war in the Military-industrial complex sandpit must be fed. The way we communicate to each other is a trap.

[Eric @ebrown409]

Stability is the breading ground for creativity. Many have died to make sure a steady environment was an achievable state for those who seek it. All I see now is people that squander this privilege for their own selfish needs or have it manipulated away from them unwillingly.

[Eric @ebrown409]

Are they going to get US citizens to prop up the bond market? Maybe start a presure campaign to buy war bonds again?

[Eric @ebrown409]

@mansourtarek_ @DeItaone Advertisement has been a bain on the USA for too long!

[Eric @ebrown409]

Control of the narrative that make sure their power is absolute by doing what they accused of the CCP doing as well.

[Eric @ebrown409]

We have seen time and time again speech suppression under the guise of It's a private company doing it and not the government. I can't help but think of this as a play of suppression to place yet another platform in the hands of the higher economic class of America.