November 11, 1963: Brian Epstein and Ed Sullivan sign a 3 show contract for appearances by The Beatles.
Around 73 million viewers watched their performance which, at the time, was the most-watched program in American television history.
The obesity adverse outcome story.
BMI is a poor and misleading way to quantify obesity
When the CAD-obesity definition is used, we see the increased risk of all-cause mortality (top graphs) and lesser risk for preclinical obesity (lower graphs)
@Nature
https://t.co/mxx5ENViwz
A study on accelerated aging with chemotherapy for breast cancer
More aggressive chemo, improved breast cancer survival but a tradeoff of accelerated biological aging and increased risk of non-breast cancer mortality
https://t.co/YONcyOHJjP
Getting it wrong for many decades.
Since the 1950's, pacemaker leads have been placed in the right ventricle. A new randomized trial challenging that dogma found marked superiority of outcomes for pacing from the left bundle branch. https://t.co/DzMUaStZjS
The counterexample to AI diffusion taking a long time is coding, where the complete transformation of a profession is well underway less than a year after real working coding agents. Faster than I would’ve expected given historical technological adoption rates in professions.
Two of the most important opportunities for medical AI:
1. Give the gift of time to clinicians, to promote the patient-doctor relationship
2. Improve accuracy of diagnosis and treatments
Both are helped by this type of work
It's hard to beat @emollick for an up-to-date, independent assessment of AI, no less where we're headed. His new book is CO-EXISTENCE. We discussed that and a lot more in the new Ground Truths today
The impressive impact of strength training for preserving muscle mass while taking a GLP-1 drug for obesity, as seen in randomized trial @NatureMedicine
T=tirzepatide alone (Zepbound), T + REx=drug with resistance exercise
https://t.co/yLDvQ1lo5z
Setting an unattainable objective. I wish it would come true, but curing all these diseases in the next 10 years is impossible.
And I'm very optimistic about the impact of AI for improving health.
Had early access to Gemini 4 Carbon, it is a very good model that improves on Argon. It is useful to have an AI that thinks differently than Claude/GPT & is still highly capable, but has its own strengths & weakness
One fun demo: I gave Carbon a video clip & it reproduced in 3js