Excited to share @Nature: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein (wt) structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation. 🧵
https://t.co/E2fZXw2Pom
A part of my PhD work is now out in @Nature.
We address one of the biggest open questions in GPCR biology — the structural basis of ligand efficacy.
Using naloxone (Narcan) and loperamide, we capture GDP-bound MOR–Gi intermediates, visualize nucleotide release, and derive a comprehensive model of how these drugs modulate signaling:
🔗 https://t.co/oYf3diWHpu
People supporting and cheering police atrocities and bulldozer justice for years, are giving morality lectures over a slap. Please clean your faces in the gutter and then talk.
Main kaun hoon, kaun nahin, jaanne ke liye, READY AH?
#JawanPrevue Out Now!
#Jawan releasing worldwide on 7th September 2023, in Hindi, Tamil & Telugu.
https://t.co/6uL1EsSpBw
I don’t think I can express what we feel for you! Booked a screen and saw it with everyone I loved and it was a celebration like no other ❤️ thank you @iamsrk#AskSRK what’s next for Pathaan? 🇮🇳part 2?
Between these two pictures.. all of us have had a journey to cherish. @iamsrk’s journey… And just in case you don’t get tickets for Pathaan… you know what to watch!!