Enoch Lok Him Yuen

Researcher at @imperialcollege with @Tolga_Bzkrt l Plant Immunity l Alumnus @CambridgeJBS l 100+ countries l Quizzer l Puzzler

[Enoch Lok Him Yuen @EnochYuen]

⚠️Excited to share my latest in @ThePlantCell🌱! We show that chloroplasts form membrane contact sites (MCS) with the pathogen interface to drive focal immunity, mediated by a tethering complex🔗!

Full story 👉 https://t.co/LE3SVlxp5i

#PlantScience #PlantImmunity

[Dr. Wenbo Ma @wenboEffector]

Fully funded PhD studentship (UK student only) in my group! 👇

Application deadline: July 30th, 2026

Start date: October 1st, 2026

Using single-cell transcriptomics to understand plant disease (MA_S26DTP3) 2026/27 | UEA https://t.co/l5nMI2S2wA

[Tolga Bozkurt @Tolga_Bzkrt]

These N-terminal caps could be quite handy to prevent/dampen NLR autoactivity when engineering new immune receptors.
Great collaboration with Suomeng Dong's lab (Nanjing) and @amiralito_ (TSL), @EnochYuen @TarhanEI @Freddie_King00 @Nickeilmann (ICL)

[Tolga Bozkurt @Tolga_Bzkrt]

Our new paper is out: surface immune signalling can unlock an NLR immune receptor through alternative splicing. In potato Rpi-vnt1.1, splicing removes an N-terminal “safety cap”, priming the receptor for resistosome assembly and defence.

[Tolga Bozkurt @Tolga_Bzkrt]

Surface immune signaling unlocks NLR activation through mRNA alternative splicing | Science https://t.co/o39aijkVi0

[The Sainsbury Laboratory @TheSainsburyLab]

New Publication: A potato late blight pathogen effector interacts with ENTH-domain protein TOL9a and an activated helper NLR to suppress immunity (2026)

https://t.co/lV5RmaB5oy

[Panagiotis Sarris @PanosSarris]

A potato late blight pathogen effector interacts with ENTH-domain protein TOL9a and an activated helper NLR to suppress immunity.
https://t.co/DCh6PsxKxt

[Mauricio Contreras @mpcontreras4]

As seen on @biorxivpreprint: our story on how the dreaded late blight pathogen hijacks a helper NLR pathway is now out in its final form in @ScienceAdvances 🎉

Meet AVRcap1b: the two-faced effector 🧵👇
https://t.co/TsmdMNfb8u

[Diana Gómez De La Cruz @dianagdlc]

So proud to see this story finally out!🎉 We added new data since our previous preprint—transgenic barley plants with an engineered immune receptor that fights off two fungal pathogens at once. Short 🧵and link to the original preprint thread👇
https://t.co/e0SrTwBMvc

[Philip Carella @Phil_Carella]

Happy to share our latest pre-print on the evolution of TIR-mediated immunity in plants. Led by @E_B_Kennedy and @Khongsam_Chia from our lab @JohnInnesCentre with a big assist from @mhz1989 and @jonathandgjones @TheSainsburyLab. Check out El's twitter thread below:

[Mauricio Contreras @mpcontreras4]

Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇
https://t.co/H55EMmrtZn

[Sebastian Schornack @dromius]

Be part of OMGN! Open to all researchers with an interest in oomycetes, from molecular genetics & genomics to biology, population biology, and ecology, at either an experimental or a computational level. Investigators new to the field are always welcome https://t.co/8ihV348OKc

[AmirAli Toghani @amiralito_]

Protein structure prediction changed biology. Protein assembly discovery is next.
We present SNI (Structural Novelty Index), a scalable framework for finding new protein complexes.
We used it to uncover an unexpected resistosome assembly: 11-mer. 🧵👇🏻

https://t.co/bCADVEnE6b

[Sophien Kamoun @KamounLab]

You’ve seen it @biorxivpreprint but here is the latest version—a twist in #NLRbiology—the TIR-NLR to NRG1 pathway channels calcium from organelles.

Besides the cool science, I love it how several @TheSainsburyLab alums collaborated on the project. #TEAM #CelebratingAlumni 😍 😎

[Tarhan Ibrahim @TarhanEI]

Our NRG1 story is out now in @ScienceMagazine!

https://t.co/qpt6QAOgW0

Also check out this news letter from @imperialcollege @BezosCentre for a nice summary!

https://t.co/3XnkPbW0pN

A great team effort @Tolga_Bzkrt @KamounLab @JiorgosKourelis @jonathandgjones @AdamWu9527

[Tolga Bozkurt @Tolga_Bzkrt]

Final version of our NRG1 MS is out!

We uncover a surprising mechanism: the helper NLR NRG1 targets organellar membranes to trigger immunity
Great collaborations with @KamounLab, @JiorgosKourelis, @jonathandgjones, @AdamWu9527, and the @Phil_Carella labs!
https://t.co/P9OMT7NgtR

[Freddie King @Freddie_King00]

Excited to share our preprint using Rhizobium rhizogenes AS109 for agroinfiltration, facilitating strong transient expression across non-model plants including sweet potato, mustard, Medicago and faba bean!

https://t.co/mgrWvCFBK1

1/7

[Enoch Lok Him Yuen @EnochYuen]

New review out in Open Biology by @royalsociety 🌱🔬🧬!
Together with @Tolga_Bzkrt, we explore how pathogens — from viruses and bacteria to fungi, oomycetes and nematodes — hijack or suppress host autophagy to promote infection in plants.

🔗 https://t.co/5Q3JZ41EMt

#Research #Autophagy #PlantImmunity

[Sebastian Schornack @dromius]

New Preprint! Inactivating two barley SCAR genes as strategy to render roots resistant to a root rotting pathogen while enhancing symbiotic Mycorrhiza fungi colonisation & retaining normal growth and seed yield. This work has been led by @BrummSabine https://t.co/OIkEoEoVqn

[Enoch Lok Him Yuen @EnochYuen]

Our paper in The Plant Cell 🪴 showed that chloroplasts form defence-related membrane contact sites (MCS) with the pathogen interface, helping drive focal immunity in plants:
https://t.co/N3ZMePV6iD
@Tolga_Bzkrt

[The Plant Cell @ThePlantCell]

Yuen loves plant science because it bridges fundamental discovery with real-world impact. #WeAreASPB
https://t.co/8wmRHuCf9T

[Enoch Lok Him Yuen @EnochYuen]

Really excited to see this out - some incredibly stunning time-lapse imaging capturing the full dynamics of plant immune cell death!

[Chih-Hang Wu @AdamWu9527]

I’m very excited to share this work! Understanding plant hypersensitive cell death has been a key challenge. Using time-lapse imaging, we captured the full process: from calcium influx to organelle breakdown and cell collapse. @YiFeng_eYFP @IPMBSinica
https://t.co/3wVNWr4Au9