In #GENETICS, @kauralasoo, @Eric_Fauman, and colleagues show how horizontal pleiotropy can mislead Mendelian randomization to infer implausible causal relationships between an exposure and an outcome. https://t.co/OD4jv3FYd5
@BrentRichards19 Interestingly variants in HAL have also been associated with risk of sun burn and skin cancer.
https://t.co/tIFSqS2boN
What's going on here?
@Eric_Fauman@mbeisen@JoezMcfLy Based on public interactions, the most famous person to visit your profile is Atul Butte, the renowned bioinformatics expert and UCSF distinguished professor who engaged with your GWAS posts.
@DrAnneCarpenter@iRanitK The mind map feature is very nice. The pod cast feature seems gimicky at first but it's actually a fun way to make a new pile of research papers accessible for your commute.
@MariosGeorgakis Key insight:
"At 72% of the gold-standard gene loci, other eGenes were detected providing potentially misleading gene targets."
When the true causal gene was not an eGene "other eGenes were detected in 70% of the loci, which may lead to a misleading inference"
@jmuiuc@anshulkundaje "Reckless" implies the regime's actions are inadvertent.
The goal of trump and the Republicans is to destroy scientific research and higher education in the US.
The most famous heuristic in mapping gwas snps to genes is
"it's usually the closest gene".
But only slightly less well-known is this:
"consider the colocalized phenotypes."
https://t.co/6nKcKYC29t
@catgyoung That is the pretense.
This regime is destroying research institutions because that's what autocracies do in order to centralize power and control the narrative.