Keep Calm and Adapt: AI will eliminate some jobs, but could create many more. A job is not just a task, but a responsibility, and an opportunity to create new tasks. https://t.co/nYMfql2Son
More good news for cell therapy from Avobis Bio. AVB-114 proved superior to standard of care for Crohn's. Did Takeda punt on darvastrocel too soon?
https://t.co/WcqlBsHCQs
#CellTherapy#MSC#RegenerativeMedicine
Good news for #CellTherapy : Orca Bio Announces FDA Acceptance and Priority Review of the Biologics License Application (BLA) for Orca-T® to Treat Hematological Malignancies
FDA assigns PDUFA target action date of April 6, 2026
David Baltimore was a giant influence in many, many scientific careers, including mine. Grateful for his contributions and sad to hear of his passing. https://t.co/Og0cZ0CH43
My sense of it is that much more experience with the LLM approach is needed before using them in critical applications. I agree that, at this point, they often pattern match. #AI
🧬 Bad news for medical LLMs.
This paper finds that top medical AI models often match patterns instead of truly reasoning.
Small wording tweaks cut accuracy by up to 38% on validated questions.
The team took 100 MedQA questions, replaced the correct choice with None of the other answers, then kept the 68 items where a clinician confirmed that switch as correct.
If a model truly reasons, it should still reach the same clinical decision despite that label swap.
They asked each model to explain its steps before answering and compared accuracy on the original versus modified items.
All 6 models dropped on the NOTA set, the biggest hit was 38%, and even the reasoning models slipped.
That pattern points to shortcut learning, the systems latch onto answer templates rather than working through the clinical logic.
Overall, the results show that high benchmark scores can mask a robustness gap, because small format shifts expose shallow pattern use rather than clinical reasoning.
A study of 1452 undergrads at Northwestern and Michigan between 2023 and 2025 found that 88% pretended to hold more left wing views than they actually had in order to succeed socially or academically.
Is Chain-of-Thought Reasoning of LLMs a Mirage?
... Our results reveal that CoT reasoning is a brittle mirage that vanishes when it is pushed beyond training distributions. This work offers a deeper understanding of why and when CoT reasoning fails, emphasizing the ongoing challenge of achieving genuine and generalizable reasoning.
... Our findings reveal that CoT reasoning works effectively when applied to in-distribution or near
in-distribution data but becomes fragile and prone to failure even under moderate distribution shifts.
In some cases, LLMs generate fluent yet logically inconsistent reasoning steps. The results suggest that what appears to be structured reasoning can be a mirage, emerging from memorized or interpolated patterns in the training data rather than logical inference.
... Together, these findings suggest that LLMs are not principled reasoners but rather sophisticated simulators of reasoning-like text.
The staggering drop in new startups in China.
Entrepreneurship is one barometer of authoritarianism and its effect on culture. In the long run, authoritarian economies decline because they forestall disruption, and thereby forestall progress.
At @NIH, we want a culture where people can discuss and disagree about ideas without trying to destroy the person for having those ideas. There should not be an orthodoxy in science that determines truth.
Read more in my interview with @reason how dissent in science must be protected ➡️ https://t.co/oJSmGqe1CN
Macrophages are key in liver disease. Here is another nice paper describing the intricate biology of these cells in alcohol-related liver disease. HepaTx is working to leverage this biology for the benefit of these patients. #celltherapy#liverdisease
https://t.co/xVeTmQ7Fwt
Mesoblast is making strides in their MSC cell therapy business, as highlighted in their recent press release concerning Revascor and the label extension for Ryoncil. The pricing strategy is raising concerns from some. #celltherapy
https://t.co/Q2YAeDa2FT
Social gatherings can be tough when you’re managing #MASH. Aroosha opens up about the everyday challenges of sticking to a liver-friendly lifestyle and how she stays committed. More in #SharingJourneys https://t.co/czbpcwCh3j
Telling children that puberty is harmful to them is grossly unethical. Most gender dysphoria resolves after puberty and there’s mounting evidence that blockers cause irreparable harm. It will never cease to shock me how many people pushed for the chemical castration of children.
We’re taking steps—literally—for Global Fatty Liver Day alongside the Global Liver Institute to raise awareness for #fattyliverdisease, a silent but serious condition impacting more than 115 million people worldwide.
Fatty liver disease is often underdiagnosed and can lead to severe complications like cirrhosis, liver cancer, and the need for transplant. Closely linked to obesity, type 2 diabetes, and high cholesterol, it's projected to affect 357 million people by 2030.
Fatty liver disease often develops quietly, without noticeable signs. That’s why routine liver checks are so important—especially if you’re at higher risk. Thankfully, checking your liver health today is easier than ever, with quick, noninvasive tests that can give you answers in minutes. Get screened today!
There's still time to join our team for the “Steps Around the World” challenge and help spread the word!
Sign up here: https://t.co/jlv7OHWz6e
#GlobalFattyLiverDay #LiverHealth #ArizonaLiverHealth #MoveForLiverHealth #FattyLiverAwareness
Exciting developments in regen med as Mesoblast advances treatments for heart disease! Allogeneic cell therapy shows promise in liver disease, expanding the possible treatments. Follow the latest progress from @HepaTx. #regenerativemedicine#liverdisease https://t.co/O2eSzzNkje