Eugene Ahn, MD

Integrative breast medical oncologist, Assoc Prof at Loyola/Cardinal Bernardin Cancer Center, Check out my new blog site

[Eugene Ahn, MD @eugeneahn]

Hi, check out my free vitamin D chapter, now updated with full references and a reformat to make it more clinically useful with a focus on vitamin D deficiency definition, prevalence, associated symptoms such as fatigue, and scientifically backed weight-based formula that will improve your efficiency at addressing vitamin D deficiency to 90%. #integrativeoncology #integrativemedicine #vitaminD #fatigue

https://t.co/bUBCd9Iol4

[Eugene Ahn, MD @eugeneahn]

Unbelievable commitment and relentless passion to publish the first comprehensive textbook on Integrative Oncology! Well done, my fellow luminaries with @integrativeonc! The evidence base for the field now justifies 66 chapters though I wish we had one more to have made the debut edition magic number 67!

Discount code: BIOMED30 for 30% off

[Society for Integrative Oncology @Integrativeonc]

We are thrilled to share this special announcement from Dr. Ting Bao regarding the release of the Comprehensive Integrative Oncology textbook.

66 comprehensive chapters covering the full spectrum of care.

🔗 Get your copy here: https://t.co/q6fWMYJSL5

[Eugene Ahn, MD @eugeneahn]

Awesome progress but do not forget that TP53 mutations are likely a biomarker for patients who stand the most to gain from vitamin D replacement therapy and it is far less toxic and expensive. See subset analysis of the AMATERASU study. https://t.co/ToYA0q8KhI and check out my free vitamin D chapter at https://t.co/ipQhgnstt9 #healthequity #vitaminD #integrativeoncology

[NEJM @NEJM]

In a phase 1 study of the oral p53 reactivator rezatapopt in heavily pretreated patients with TP53 Y220C–mutated solid tumors, the most common adverse events were nausea and vomiting, and the overall response was 20%. Full PYNNACLE study results: https://t.co/LBqROGlouc

Science behind the Study: Restoring Function to a Variant of p53 in Solid Tumors https://t.co/5Ox6Kuax6Q

[Eric Topol @EricTopol]

A psychedelic quickly reduced depression (in patients with major depression disorder) in a small, double-blind placebo randomized trial @NatureMedicine
https://t.co/vvug72VGBi

[Eugene Ahn, MD @eugeneahn]

https://t.co/mbhLpaNCnN if you want to learn why this NEJM post is totally missing the point. 70% of Americans are low and IOM and Endocrine Society guidelines ignore the fact that vitamin D is a weight based drug and fixed low dose supplementation is expected to be ineffective in addressing this epidemic.

[Matthew D. Sacchet @MatthewSacchet]

Please find the full PDF on our website and from the publisher here:

https://t.co/f2BqKCyhMY

https://t.co/67Cc7M9NeH

https://t.co/q0luQAUBXB

May this work benefit many 🙏

[Eugene Ahn, MD @eugeneahn]

@DrSamuelBHume Meta analysis of crap yields crap. None of these studies offered weight based dosing which is just basic pharmacokinetics. These studies show low dose indiscriminate supplementation sucks for this endpoint

[Society for Integrative Oncology @Integrativeonc]

Save the Date | SIO 23rd International Conference
📍 Detroit, Michigan (MGM Grand) Sept 29 – Oct 1, 2026
Cultivating Community & Belonging in Integrative Oncology
Hosted with Henry Ford Health.
Hybrid event: in-person & virtual options.

[William A. Wallace, Ph.D. @WilliamWallace]

Your gut isn’t just digesting food… It’s running a biochemical factory that keeps you alive.

Most people think the colon is just “where waste goes.”
But this illustration shows something more:

Your colon is one of the most underrated metabolic organs in the entire body.

Inside this 5-foot stretch of tubing, billions of bacteria are:
🔥 Creating vitamins
🔥 Producing short-chain fatty acids (the fuel your colon cells run on)
🔥 Detoxifying harmful compounds
🔥 Breaking down proteins into neurotransmitter precursors
🔥 Regulating your immune system
🔥 Deciding whether you feel inflamed, bloated, focused, or foggy

And all of it is happening silently, every hour of every day.

Looking closer at what this one diagram reveals:

🔸 Fiber → SCFAs (butyrate, acetate, propionate)
These molecules lower inflammation, feed colon cells, improve insulin sensitivity, and even influence mood.

🔸 Protein → amino acids → neurotransmitter precursors
Yes, your gut bacteria help shape serotonin, dopamine, and even histamine levels.

🔸 Your colon detoxifies more than your liver gets credit for.
Phenols, ammonia, indoles, cresol, skatole. Your microbes help neutralize them before they ever hit your bloodstream.

🔸 Gas, pH changes, mucus secretion, metal excretion, nutrient salvage; it all happens here.
Your colon saves water, electrolytes, energy, and even rescues calories you would otherwise lose.

🔸 The final 135 grams of stool are only a fraction of the metabolic work happening behind the scenes.

This is why gut health affects EVERYTHING: digestion, immunity, mental clarity, inflammation, skin, sleep, metabolism; all of it.

Your gut isn’t a waste pipe.
It’s an ecosystem, a chemical lab, and a second brain whispering instructions to the rest of your body.

Source:
Thieme’s Color Atlas of Physiology

[Loyola Medicine @LoyolaHealth]

When facing a cancer diagnosis, patients often find themselves navigating a mix of emotions, medical decisions and physical challenges. However, exercise can be a powerful tool during cancer treatment. Learn more from oncologist Eugene Ahn, MD: https://t.co/OsGRYxvRFX

[Society for Integrative Oncology @Integrativeonc]

SIO® has launched interactive CME training modules to help you put the SIO practice guidelines into action!

2022 SIO Pain Management Guidelines
2023 SIO Anxiety and Depression Guidelines

Find the link to the modules + survey here https://t.co/GPk0yOT2RB

[Eugene Ahn, MD @eugeneahn]

First snowfall of winter in Chicago, so no better time to post a public service announcement/reminder: Do you know your vitamin D25 level? Did you know over the counter D3 leads to production of LL37 which lyses/destroys RSV, influenza, and yes all coronaviruses including COVID19. Let's bring scientific knowledge into action and make America Healthy Again #MAHA. Vitamin D Deficiency in Cancer Care: An Urgent Call to Action https://t.co/AeF4tdSAk9

[Eugene Ahn, MD @eugeneahn]

For the love of God, never sign up for Meridian insurance. They just denied neulasta for high risk chemotherapy saying to use 7 day neupogen instead, then denied that 7 day neupogen as well, and then required a patient to sign an 'authorization form' to let me (her oncologist) to appeal the denial and only allows this patient form via fax, as if we all have fax machines still. It's two weeks after her chemotherapy and Meridian is doing their absolute best to not get it covered/delivered. Doctors and patients alike just want less obtuse insurance approval protocols designed to frustrate care and worsen quality of life for Americans #MAHA @RobertKennedyJr

[Eugene Ahn, MD @eugeneahn]

Not to say doctors are immune to conflict of interest, but come on man...politicians and athletes take COI to a level of professional pride these days.

[Joe Pompliano @JoePompliano]

The FBI is holding a press conference right now on the details around this morning's sports gambling bust.

Here are some of the highlights:

1. Current and former NBA players and coaches Chauncey Billups, Terry Rozier, and Damon Jones have been arrested.

2. This was an illegal gambling and sports rigging operation that spanned years across 11 states. In total, 30 individuals have been arrested (13 mafia members).

3. The case involves La Cosa Nostra (the Italian mafia).

4. Charges include illegal gambling, wire fraud, and extortion.

5. There are two separate indictments. The first involves six defendants accused of participating in a sports corruption scheme that exploited insider information involving NBA players and teams. The defendants leveraged their connections to place prop bets based on confidential insider information, winning tens of thousands of dollars per bet.

The second indictment involves 31 defendants charged with participating in a nationwide scheme to rig illegal poker games. The FBI says they used high-tech cheating technology to steal millions of dollars from victims in underground poker games that were secretly fixed.

6. The two cases are separate, but there are three overlapping defendants, including former NBA player and coach Damon Jones.

7. The FBI says that NBA player Terry Rozier told the defendants that he was going to leave a game early on March 23, 2023, with an injury. The defendants then placed more than $200,000 of wagers on the unders for his prop bets, with Rozier leaving the game after nine minutes. Those bets paid out tens of thousands of dollars in profits, and the defendants and Rozier counted the money at his house.

8 The FBI says that former Raptors player Jontay Porter was threatened to participate in the sports gambling scheme because of his gambling debts.

9. Teams that were bet on during the sports gambling scheme include the Charlotte Hornets, Portland Trail Blazers, Los Angeles Lakers, and the Toronto Raptors.

10. The rigged poker games occurred in the Hamptons, Miami, Las Vegas, and Manhattan.

11. The poker scheme targeted victims who were lured to participate in rigged poker games by the chance to play alongside former professional athletes. These athletes included Chauncey Billups and Damon Jones.

12. The FBI says that the defendants utilized altered shuffling machines to read the cards in the deck and then relayed that information to an off-site operator. The offsite operator — known as the "quarterback" — then sent that information to someone at the table.

13. The FBI also says that the defendants utilized other cheating technologies, including poker chip trays that read cards through hidden cameras, special contact lenses and glasses that could read marked cards, and x-ray poker tables that could read cards face down.

14. The FBI says that the defendants robbed a victim at gunpoint to acquire a rigged shuffling machine.

15. The sports gambling investigation is called "Operation Nothing But Net," while the poker investigation is called "Operation Royal Flush."

16. The FBI has been working on this investigation for four years, with victims losing at least $7 million.

17. One specific victim lost at least $1.8 million.

18. The FBI reviewed thousands of hours of video evidence and executed more than two dozen search warrants.

These are just accusations at this point. I am just pointing out details from the FBI's investigation.

For more updates, join 135,000 others who read my 3x weekly newsletter: https://t.co/OgN8EYHbxw

[Eugene Ahn, MD @eugeneahn]

“Environment” = not enough sunshine or outdoor activity creating a unique imbalance of vitamin D particularly in African Americans. >90% of African Americans are Vitamin D deficient in the US! And most doctors do not know how to replace a severe deficiency - Which is why i published a vitamin D chapter for free online at https://t.co/ipQhgnstt9

[Eugene Ahn, MD @eugeneahn]

“Environment” = not enough sunshine or outdoor activity creating a unique imbalance of vitamin D particularly in African Americans. >90% of African Americans are Vitamin D deficient in the US! And most doctors do not know how to replace a severe deficiency - Which is why i published a vitamin D chapter for free online at https://t.co/ipQhgnstt9

[Eugene Ahn, MD @eugeneahn]

@ErikaHamilton9 Maintenance therapy suddenly becomes more toxic. Definitely subset analysis will be eagerly followed

[Michael Levin @drmichaellevin]

Final version is out: @SantoshManicka

https://t.co/v2f82HDQSD

"Field-mediated bioelectric basis of morphogenetic prepatterning"

#morphogenesis #bioelectricity #fields

"Intercellular bioelectric communication plays an important role in morphogenesis, often modeled using localized non-neural networks generating spatial patterns of membrane potential (Vmem). Here, we find that the electrostatic field contributes to this process, via a synergetics (à la Haken)-based mechanism, by enhancing the complexity of Vmem patterns through a coarse-grained projection. We leverage this property of the field to automatically optimize transient signals from a symmetry-breaking organizer region in the boundary of the tissue to mold Vmem patterns in the bulk. Two models optimized in this way exhibit contrasting “mosaic” and “stigmergic” pattern-coding strategies, depending on their field sensitivity strengths. Interestingly, the stigmergic model recapitulates the qualitative developmental sequence of the bioelectric craniofacial prepattern observed in frog embryos. These results highlight the potential of the electric field both as a facilitator of collective patterning and as a macroscale interventional target for applications in regenerative medicine and bioengineering."

[Eric Topol @EricTopol]

How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
https://t.co/4dRP7aInfw