Evenil

Coder, trust me I'm an engineer. "Testing shows the presence, not the absence of bugs" - Dijkstra

[Evenil @Evaenil]

My agreement with socialism is very low. Yup. https://t.co/x1bGbH3DMy via @idr_labs

[Evenil @Evaenil]

@not__vee If aging is possible to be reverted (at least physical appearance, most of those ugly bitches will probably back down. Of course you can't remove ugliness of what's inside, but step by step.

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters.
Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery.
Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado.
Here's what they erased.
Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls.
Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease.
Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there.
So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath.
Not patched. Reversed.
Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored.
Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible.
The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away.
But something considered permanent for forty years just came off human tissue.
We spent a century learning to slow aging. Someone finally figured out how to erase it.
Thank you @theallinpod @friedberg @chamath @pesottas

[Evenil @Evaenil]

@pureMetatron Any game where you learn to draw. Might as well learn something usefull while losing 1 year of my life.

[Evenil @Evaenil]

@shitpost_2077 @sleepy_devo

[Evenil @Evaenil]

@sleepy_devo By this do you mean her, or her positions? Opposing her positions, I would hardly call it constantly, abolish ice was quite popular in days of George Floyd cult. I f you mean they are opposing those views right now, yeah, they turned out to be unpopular.

[Evenil @Evaenil]

@CovaDax @flatterkatz @sleepy_devo Ciri is a fictional character, so she cannot. More than that, Sapkowski said that games are not cannon and he started writing books again.

[Evenil @Evaenil]

@CovaDax @PotentiallyDad @sleepy_devo I read the books in Polish. Articles cite things that didn't happen in the books or dismiss the rape entirely, hence AI slop. Or fanfic.

[Evenil @Evaenil]

@Aris_Utensil Those two groups have something in common. Law overlooks their misdeeds. Both groups can flaunt their power, whenever by calling someone racist or intimidating with money.

[Evenil @Evaenil]

@PotentiallyDad @sleepy_devo I know. However the amount of articles I found that says that Ciri is lesbian is weird. AI slop everywhere.

[Evenil @Evaenil]

@sleepy_devo But again, even evidence of her bisexuality can be attributed to her desperate situation — trapped with a male party member who had tried to rape her. She chose the lesser evil.

[Evenil @Evaenil]

@sleepy_devo No, it makes your example terrible, because you can ascribe this relationship to Stockholm syndrome and drugs. She's not a lesbian. Every other relationship she had was with a man. You can try to say she's bisexual. But I would say that her circumstances are complicated.

[Evenil @Evaenil]

@sleepy_devo Historical longitudinal studies (often pre-2010s) consistently found that a majority of children with gender dysphoria no longer experienced it after puberty. After 2010 adoption of puberty blockers increased, so data is scewed.

[Evenil @Evaenil]

@sleepy_devo Filling the pool with liberal tears. Duh.

[Evenil @Evaenil]

@sleepy_devo You're not American, you don't get to choose. You're against democracy anyway.

[This You? @Thiss_Youu]

Trump in 2024:

“Iran was broke under Donald Trump. Now Iran has $300 billion dollars because they took off all the sanctions that I had”

[Evenil @Evaenil]

@sleepy_devo @Sargon_of_Akkad Isn't this a self burn? Because you didn't talk about Biden crime family neither. And it's not like Lotus-eaters never criticizes Trump. And they kind of have more important stuff to care/report about. It's more likely that Beau would cover this.

[Evenil @Evaenil]

@sleepy_devo Thank god for grok, so nobody wastes time on stupid claims.