Eva Notari

Coiled Coil Molecular Dynamics & Design @EdinburghChem | @EastbioDTP PhD researcher at @julienmich80 and @ChrisWellsWood labs

[ACS Publications Bio & Med Chem Content @ACSBioMed]

Coxon Lab (Edinburgh) reports hydrocarbon‑stapled peptides targeting the CGRP receptor, enhancing stability & maintaining activity, advancing the design of metabolically robust peptide therapeutics. #JMedChem

https://t.co/6lkvyrddD5

[Tadas Kluonis @TKluonis19677]

Wells Wood Lab protein design landed in top 1.2% in Adaptyv Nipah Virus Protein Design Competition in which 680+ participants submitted over 10,000 designs.

This was a great team effort with @EvaNotari, @DrLeucine , @mjstam, and @s_mert_unal @ChrisWellsWood

[Leonardo V. Castorina @DrLeucine]

All designs were scored with MD magic from @EvaNotari and our very own "Stam score" (@mjstam ), and we filtered out any candidates that showed non-specific co-folding.

Fingers crossed for the lab experiments!

[Leonardo V. Castorina @DrLeucine]

We (@ChrisWellsWood Wood's lab) have taken the lead at the @adaptyvbio competition against the Nipah Virus!

Give us your ⭐️ for our other designs here:

https://t.co/LpIal8Vcu7

[Eugene Shrimpton-Phoenix @ESP_Proteins]

We are pleased to announce drMD: Molecular Dynamics for Experimentalists!
Read the paper at:
https://t.co/SyGRrJHy2F
Get the code from:
https://t.co/c05hkkhNxg
#proteins #moleculardynamics

[Chemical Communications @ChemCommun]

New Communication out NOW from @CampopianoGroup, @ArtOxiZymes, @jarvis_lab, @EdinburghChem

#openaccess

'Installation of an organocatalyst into a protein scaffold creates an artificial Stetterase'

https://t.co/2ISS6KeSni

[Jarvis Lab @jarvis_lab]

Congratulations Alice and all involved! 📰🥼👩‍🔬

@ArtOxiZymes, @CampopianoGroup, @Brew_Richard, @ChrisWellsWood, @klemencic_eva, Mert and Evangelia

[Campopiano Group @CampopianoGroup]

Congrats to Alice on publishing her PhD work in Chem Comm.

The first example of a NHC-modified protein displaying Stetterase activity!
Great work.

@ArtOxiZymes @EdinburghChem

https://t.co/sDbfBzs3Ui

[bioRxiv Bioinfo @biorxiv_bioinfo]

drMD: Molecular Dynamics for Experimentalists https://t.co/X8Y981IGxX #biorxiv_bioinfo

[Christopher W. Wood @ChrisWellsWood]

We are pleased to announce the release of The Protein Design Archive. Our comprehensive database of designed proteins highlights the triumphs and challenges of the field: https://t.co/HXe2Lc7YpJ
Preprint:https://t.co/VAXycmYs9q
@mjstam @MartaChronowska @WoolfsonLab #proteindesign

[Christopher W. Wood @ChrisWellsWood]

New paper in PLoS Comp Biol! @jack_oshea97 used molecular dynamics to find sites for cpGFP insertion, creating functional biosensors in a periplasmic binding protein. He identified known sites but also discovered new ones, which he validated in the lab.

https://t.co/25yDo84cZH

[Eva Notari @EvaNotari]

Last week I presented my research on predicting the oligomerisation states of coiled coil proteins with MD simulations at the annual Joseph Black conference organised by @EdinburghChem. Very pleased to have received an award for the best oral presentation in Physical Chemistry.

[Michael Stam @mjstam]

New preprint out!🚨We performed a large scale analysis of physicochemical features extracted from over half a million AlphaFold structural models, and using data-driven methods we showed a link between these features and in vivo behaviour of proteins. Find out more below⬇️1/9

[Leonardo V. Castorina @DrLeucine]

🍻I will be giving a @pintofscience talk titled "How to Create a Protein" on May 14 in Edinburgh! 🍻

https://t.co/ed1Y3v4rwC

[Davide Michieletto @Dmichiel1]

#pint24 is live!
If in Edinburgh, come and join me at Bar50 on May 13 for a night of 🔬🧪🧬 and some 🍺🍺!
Sneak peek...I will talk about "kinetoplast DNA" 🧬🪢 and how bloodsucking parasites are tech-ing us out 👀
https://t.co/DUWh2z2QuT

[Caroline Morris @PeptideCaroline]

If you're in #Edinburgh this May, why not pop along to @pintofscience to learn about some of the ways current research is revolutionising healthcare? Join us on May 14th for a 🍺 and some 🧪, and find out how I'm trying to make peptide drugs more sustainably! #pint24 #TechMeOut

[Eva Notari @EvaNotari]

Very happy to have collaborated with @AdamSchofield__ @Dr_CR_Coxon on optimising a HPLC focused gradient for peptide purification. Check our application note below🧪

[Adam Schofield @AdamSchofield__]

Very happy to share an application note on generating a focused gradient for #peptide #purification using the @TeledyneLABS1 #ACCQPrep with water and acetonitrile (0.1% TFA) mobile phases. @EvaNotari @Dr_CR_Coxon

https://t.co/7kUNIYKW9f

[Christopher W. Wood @ChrisWellsWood]

Not sure how many people that follow me use CCBuilder, but it has been down due to computer issues. I'm pleased to say that it is now back online at a new URL with some minor updates: https://t.co/oqjQdb7wvC
@WoolfsonLab

[Adam Schofield @AdamSchofield__]

I had a fantastic experience in giving an oral and poster presentation at #PPSG2023 about new #migraine treatments. Very honoured to win best poster! Well done to everyone giving talks and posters today. Now let’s hope #StormBabet calms down so I can get home… @RSC_PPSG

[Julien Michel is also on Mastodon @julienmich80]

@EastbioDTP PhD opportunity ''Multifidelity simulations for high-throughput generative protein engineering pipelines'' collaboration with @DrStracquadanio @EdinburghUni https://t.co/0M9m309FlM