Extracellular Matrix News

An online resource for the extracellular matrix and tissue engineering research community. Part of the @STEMCELLTech Science News service.

[Extracellular Matrix News @ExtracellMatrix]

GIVEAWAY! 😍🎉

Don't miss your chance to win a pair of @STEMCELLTech science socks! 🧦

To enter, sign up to receive the latest research highlights in your field delivered to your inbox with STEMCELL Science News. 💌

🔗 Learn more: https://t.co/XFg0BHJqeE

[Extracellular Matrix News @ExtracellMatrix]

🚨 New in @sigtrans_sttt: Scientists identify conserved immunomodulatory cancer-associated fibroblast (#CAF) subtypes across cancers, reveal distinct cytokine-associated CAF programs, and support stromal reprogramming as a promising strategy to enhance #immunotherapy efficacy.

🔓 #OpenAccess | https://t.co/8nlfdehwuF

[Extracellular Matrix News @ExtracellMatrix]

🤔The primary treatment for muscle-invasive and metastatic #BladderCancer is cisplatin-based chemotherapy, but chemosensitivity and severe toxicity severely limit its clinical application.

In this Advanced Science (@AdvPortfolio) article, scientists synthesized MP-12C, a melatonin-conjugated platinum(IV) prodrug that remodels the ECM and enhances the sensitivity of bladder cancer cells to cisplatin!

#OpenAccess🔗 https://t.co/aKnFoyGZgF

[Extracellular Matrix News @ExtracellMatrix]

This @ImmunityCP study found that #microglia exhibited acute and progressive morphological responses that preceded but paralleled ethanol-induced sedation.

📖 https://t.co/U9vzT5FbvJ

First authors Evi Paouri and Sarah Stanko show that genetic deletion of microglial Myd88 protect against ethanol-induced microglial reactivity, neuronal damage and dysfunction, intoxication, and motor impairments by preventing #ECM disruption.

[Extracellular Matrix News @ExtracellMatrix]

Using temporal multi-omics, biomechanical profiling, and spatial fate mapping in #colitis models, @WeizmannScience researchers showed that colonic #ECM underwent lasting pathological reprogramming following inflammation.

🔎 https://t.co/BBE4v91pkd

Their findings, published in @ImmunityCP, redefine the ECM as a long-lived instructive compartment that encodes injury memory and promotes maladaptive regeneration.

[Extracellular Matrix News @ExtracellMatrix]

Fibrosis across kidney, bone marrow, intestine, heart and cancer: Fibrosis Frontiers: From Basic Mechanisms to Precision Therapies.

Scholarship & short talk abstracts due Nov 4.

Join @KeystoneSymp in Keystone, CO, Mar 1–4. #KSFibrosis27

https://t.co/rZhZBUcYIQ

[Extracellular Matrix News @ExtracellMatrix]

Investigators profiled primary tumor tissues using spatial #transcriptomics and identified a fibroblast-associated #ECM remodeling niche associated with metastatic status in KRAS G12C-mutant #LungAdenocarcinoma.

https://t.co/lALu2qpRL7

[Extracellular Matrix News @ExtracellMatrix]

This #OpenAccess review provides an overview of the state of the art of #ExtracellularMatrix components and function in the central nervous system, both under homeostasis and in #neurodegeneration. 🧠

Give it a read: https://t.co/RkY94srLlf

[Extracellular Matrix News @ExtracellMatrix]

This work identified epithelial #senescence-associated signaling as a mechanism linking prostate epithelial alterations to fibroblast reprogramming and #ExtracellularMatrix remodeling.

Check out the #OpenAccess paper. 👇

https://t.co/3VNLdyYF8y

[Extracellular Matrix News @ExtracellMatrix]

In lesional skin, extracellular matrix remodeling provides a complementary framework for understanding psoriasis as a disease involving both immune activation and persistent tissue-level remodeling.

Read the full paper: https://t.co/c60FmwP8AH

Led by researchers at Hubei Province & Key Laboratory of Skin Infection and Immunity and Huazhong University of Science and Technology.

#Psoriasis #Dermatology #Immunology

[Extracellular Matrix News @ExtracellMatrix]

Tumor-derived lysyl oxidase–like 4 stiffens the extracellular matrix, triggering a mechanotransduction-to-epigenetic pathway that induces CD8+ T cell exhaustion in lung cancer.

Read the study: https://t.co/QNhpe7jIRb

Led by first author Xuyu Gu at Shanghai Pulmonary Hospital and corresponding authors William C. Cho at Queen Elizabeth Hospital and Qiyu Fang at Tongji University.

#LungCancer #Immunotherapy #TCellExhaustion

[Extracellular Matrix News @ExtracellMatrix]

This year’s Party with a Purpose, an annual philanthropic gala to support the American Association of Cancer Research (#AACR), will recognize Dr. Robert Vonderheide, the Scientific Achievement Honoree, and Dr. Andrew Rech, who was nominated by Vonderheide, as the Early Career Investigator Honoree, for their achievements and continued efforts to drive new cancer immunotherapy advances. 🙌

Read the article here! https://t.co/z06nEvulD6

[Extracellular Matrix News @ExtracellMatrix]

Investigators developed an accelerated #immunomodulatory matrix reservoir integrating methylgermanane nanosheets within an active Ca2+-crosslinked alginate hydrogel. ✨

🔗 https://t.co/JRqj8coxov

[Extracellular Matrix News @ExtracellMatrix]

Dr. Di Zhao and researchers reported that B7-H3 plays dual roles in regulating #MDSCs and cancer-associated fibroblasts (#CAFs), thereby promoting tumor progression and therapy resistance, respectively. 🔬

Learn more: https://t.co/UoQDcWNtvB

[Extracellular Matrix News @ExtracellMatrix]

Aberrant tubular epithelial cell and immune-cell activation converges in the sustained activation of fibroblasts and the deposition of excess extracellular matrix, driving the progression of acute kidney injury to chronic kidney disease over time.

Read the @nature study: https://t.co/YrsgDPolYV

Led by researchers at Helmholtz Zentrum München and Ludwig-Maximilians-University in Germany.

#Nephrology #KidneyDisease #Fibrosis

[Extracellular Matrix News @ExtracellMatrix]

A new review synthesizes mechanistic insights linking cathepsin D-mediated proteolysis to epithelial junction reorganization and permeability barrier recovery.
It also highlights emerging therapeutic strategies for improving chronic wound healing.

Read the review: https://t.co/mT2MzVPd7W

Research from Adichunchanagiri University, led by first author Shobith Rangappa and senior author Manjula Rv.

#WoundHealing #Dermatology #CellBiology

[Extracellular Matrix News @ExtracellMatrix]

Challenging the prevailing fibroblast-centric paradigm, investigators provide an overview of how non-fibroblast cell types engage in dynamic crosstalk and collectively shape the biochemical and biomechanical landscape of tumors.

Led by first author Sonal Srivastava and corresponding author Antonio L. Amelio at Moffitt Cancer Center Tampa.

Check out the full review here: https://t.co/M51SfgWJyU

#ECM

[Extracellular Matrix News @ExtracellMatrix]

Researchers discussed #epigenetic mechanisms controlling cancer cell-intrinsic states, cancer cell–TME crosstalk, current epigenetic therapies, and future research directions that may lead to the discovery of new biomarkers and the development of effective epigenetic anticancer therapeutics.

▶️ Check out this #OpenAccess review: https://t.co/KsthGM6qE0

[Extracellular Matrix News @ExtracellMatrix]

Dr. Morten Thaysen-Andersen and researchers reported on the mechanistic basis for and functional consequences of glycocalyx remodeling accompanying tumor-associated #macrophages polarization.

Learn more: https://t.co/hQRuBVhhDU

[Extracellular Matrix News @ExtracellMatrix]

Emerging evidence indicates that diverse non-epithelial cell populations undergo a progressive reprogramming toward mesenchymal-like states during tumor progression.

This review names this phenomenon #mesenchymal drift and underscores its significance for next-generation therapeutic strategies: https://t.co/2XkAGThjxZ

[Extracellular Matrix News @ExtracellMatrix]

#LiverFibrosis is sustained by the dense #ECM produced by persistently activated hepatic stellate cells (aHSCs).

In this study, researchers developed an aHSC-targeted nanoplex that disrupts the rigid ECM, offering a promising antifibrotic therapy: https://t.co/lZYZNyvWlU