Ewan Pearson

[Diabetologia @DiabetologiaJnl]

Genome-wide association study in @UK_biobank identifies an interaction between metformin and CUBN gene variant that predisposes to metformin-induced vitamin B12 deficiency in T2D patients. @daniel_f_carr @LivUNIISMIB @dundeeuni @harvardmed https://t.co/5cIInE6dJ1 🔓

[Ewan Pearson @ezpearson]

So should you measure genotype before prescribing? No of course not - but it can inform on screening intervals if the genotype is known. At the very least our data establishes a causal link between metformin and B12 deficiency and highlights the need for regular B12 measures

[Ewan Pearson @ezpearson]

Who measures B12 levels in metformin treated patients? With colleagues from Liverpool We’ve published on a large pharmacogenetic effect - where variants in the cubulin gene increase risk of B12 deficiency ⁦ @DiabetologiaJnl⁩ ⁦@dundeeuni⁩ https://t.co/1gwWi2L39z

[Ewan Pearson @ezpearson]

The 14% of white population with AA genotype are 2.5 times more likely to require B12 replacement GG. Equates to 10% requiring B12 replacement by 11 years after starting metformin with AA genotype vs 21 years for GG. A large effect!

[Diabetologia @DiabetologiaJnl]

To prescribe or not to prescribe? #SGLT2 inhibitors slow #CKD progression but it's unclear who with #T2D and mild/no CKD truly benefits. This new model predicts individual benefit, supporting more targeted prescribing. #PrecisionMedicine https://t.co/UaYsA0Ertu 🔓@Exeter_Diabetes

[EASD @EASDnews]

📢 Job Opportunity: @EASDnews is seeking an Editor-in-Chief for its flagship journal, @DiabetologiaJnl.

Lead one of the world’s top #diabetes #research journals.

🔗 Apply now: https://t.co/1WpuEDfBbm

🗓️ Closing date: 17 Nov 2025

#Diabetologia #Vacancy #EditorInChief

[Metabologia @MetabologiaJnl]

Metabologia is a new journal from the EASD launched last month, sister journal of @DiabetologiaJnl and open for submissions! Go to https://t.co/4kLDsooaYt for more info

[Ewan Pearson @ezpearson]

Great presentation to a packed hall from Shilpa Garg (PhD student @dundeeuni) at #easd2025 on clinical and genetic predictors of drug response in diabetes

[Prof Kamlesh Khunti @kamleshkhunti]

At @DiabetologiaJnl 60th Anniversary celebrations

@EASDnews Vienna

#EASD2025

A new exciting journal introduced

Metabologia

Delighted that the wonderful Jennifer Sargent will be the Editor-in-Chief 👏

[Ewan Pearson @ezpearson]

@DrRonaldMa1 @RAOram @UniofExeter A great paper Ronald! Highlights the need for population specific genetic risk scores for diabetes diagnostic pathways.

[Ewan Pearson @ezpearson]

Congratulations Andrew!

[EASD @EASDnews]

🏆It is with great honour that we announce the 57th EASD Claude Bernard Prize recipient, Prof. @athattersley , in recognition of his trailblazing contributions to #diabetes #research and #precisionmedicine.

Congratulations, Prof. Hattersley👏

Supported by @sanofi

@UniofExeter

[Lucy Chambers @DrLucyChambers]

💥Those of us working in science comms are perhaps too fond of the word "gamechanging" but this research by @john_den_ @athattersley @Exeter_Diabetes, published today in @TheLancet and announced at #DUKPC25, truly deserves that description 💥
#Type2Diabetes #BetterCare

[Ewan Pearson @ezpearson]

@DiabetesUK @kamleshkhunti And if you happen to live in Tayside and have diabetes the Exeter 5-drug model is now being used in our iDiabetes precision medicine implementation study https://t.co/fUErHqijtB and https://t.co/fg9YNxmddu

[Ewan Pearson @ezpearson]

This exciting paper will change how most people with type 2 diabetes are managed - predicting individual level
glycaemic response to glucose lowering drugs. Led by @john_den_ and @athattersley at Exeter (with @dundeeuni @UoDMedicine) https://t.co/8B4RnYzFEA

[Ewan Pearson @ezpearson]

For those at #dukpc2025 #dukpc @diabetesuk @kamleshkhunti Glasgow do come to our session on Thursday at 1115 when we will present this paper and show you how important simple clinical features are to choice of therapy in type 2 diabetes.

[John Dennis @john_den_]

5-drug precision prescribing for people with type 2 diabetes is here - @TheLancet our @ExeterMedmodel for optimising glucose lowering therapy using low-cost routine clinical features
Paper: https://t.co/adXEg1l3lW
Web calc: https://t.co/spF9sfqP1R

[Ewan Pearson @ezpearson]

@kamleshkhunti please retweet - thanks! @ABCDiab @youngdiabendo @Soc_Endo

[Ewan Pearson @ezpearson]

Calling all Endocrinologists. Would you like to move to Scotland? We have an Endocrine focused post with up to 12 PAs in Dundee. https://t.co/nt6CWIEtWN

[Ewan Pearson @ezpearson]

We are a dynamic team with strong links between NHS and Uni. The quality of life here is good - and for the cost of a flat in london you can by a mansion here! Message me or Paul Newey if you’d like to discuss this. @NHSTayside @UoDMedicine

[Ewan Pearson @ezpearson]

Calling all Endocrinologists. Would you like to move to Scotland? We have an Endocrine focused post with up to 12 PAs in Dundee. https://t.co/nt6CWIEtWN

[Ewan Pearson @ezpearson]

@annagloyn I’ve been similarly uncomfortable with X and thinking of stopping using it. I get spammed by musk/trump tweets and their followers (now blocked). Will join you on https://t.co/243nkCIKOg!