Excited to share our paper out today in @CellPressNews discovering RNA mis-splicing derived neoantigens & their cognate T cell receptors (TCRs) as well as characterization of endogenous neoantigen T cells in leukemia patients.
https://t.co/hVucfdL0oZ
Combined loss of the 7q genes CUX1 and EZH2 impairs the DNA damage response, driving hematopoietic clonal expansion and drug resistance. https://t.co/8pUbXL3DTs #myeloidneoplasia
@mayadh_220@DkBasmah@Ahdab_Als Congratulations Mayadh and your amazingly steadfast supervisors @DkBasmah and @Ahdab_Als for getting this work done. I wish you all the best in your scientific progress.
A new paper from @LucieDarmusey out this week in Blood Advances! Dr. Darmusey investigated how mutations in ASXL1--often associated with dysplasia--also drive myeloproliferative neoplasms, which are characterized by overproduction of mature cells.
https://t.co/1dPUKyxY27
The 1st KFMRC Conference – Medical Research Across Specialties!
A key event for researchers, clinicians, and students to connect, share insights, and drive innovation.
April 20 – 24, 2025King Fahd Medical Research Center
Join us Now
#KFMRC_Conference
🔥New Fraticelli lab publication🔥
“Pre-existing stem cell heterogeneity dictates clonal responses to the acquisition of leukemia driver mutations”
Two new figures compared to the pre-print, with more in vivo and sequential mutagenesis data.
https://t.co/2MByy2tcO0
@DrHKantarjian of @MDAndersonNews presents the Phase I/II SAVE trial results, showcasing the promising efficacy and safety of the all-oral combination of revumenib, decitabine/cedazuridine, and venetoclax in relapsed/refractory AML.
https://t.co/Q9TL6tytHM
This month's #PreprintWatch covers some exciting new results on the impact of microenvironment on hematopoietic progenitors and novel approaches to long-standing questions like self-renewal and stem cell activity! Read now on https://t.co/2NCQisaloN
Our institute is excited to host The Myeloid Precursor this Thursday, a fun mini symposium on AML with great talks, a panel discussion on AML, and a poster session. If you are in San Diego this Thursday and interested, please register here. https://t.co/8MFjjLBfTM
📄Identification of a new germline mutation: JAK2 F556V, a gain-of-function mutation 📈JAK-STAT5 signaling. This study reveals its role in familial thrombocythemia, highlighting the hereditary aspect of JAK2 mutations & their impact on platelet counts.
https://t.co/NZ6sQKeZq9