Fabrizio d'Adda di Fagagna

Principal Investigator @IFOMresearch and IGM-CNR. Begging to differ.

[Fabrizio d'Adda di Fagagna @FdAdF66]

Can an antisense oligonucleotide (ASO) targeting an RNA that is neither coding nor encoded by a gene extend the lifespan of a mammal? https://t.co/24p4d7TskP
#DDRNA #ncRNA #telomere #aging #ASO

[Fabrizio d'Adda di Fagagna @FdAdF66]

🚨 Can we kill a cell by targeting DNA that does nothing?

🧬 Our study shows Cas9 can selectively kill cells carrying a non-functional target sequence, sparing cells without it.

Weaponizing CRISPR/Cas9 for selective elimination of cells with an abe… https://t.co/s5Upaf1UgQ

[Fabrizio d'Adda di Fagagna @FdAdF66]

🚨 Can broken DNA generate a new protein?

Our study independently confirms that DSBs trigger transcription from the break—and shows, for the first time, that the resulting RNA can be translated.

Could this generate neoantigens after radio/chemotherapy?

https://t.co/r7R5lNDvoZ

[Fabrizio d'Adda di Fagagna @FdAdF66]

@GiusepeBellelli That is the plan!

[Fabrizio d'Adda di Fagagna @FdAdF66]

Disclosure: I co-founded TAG Therapeutics, exploring clinical development of this approach — this study was independent academic work.
📄 IPF paper: https://t.co/ryoVBvgsJI

[Fabrizio d'Adda di Fagagna @FdAdF66]

#IPF has no cure. Median survival: 4 years. Lung transplant is the only real option.
Our new paper shows this might be about to change. 🧵

[Fabrizio d'Adda di Fagagna @FdAdF66]

Together: #tASOs (the molecules we use) look like a real shot at treating #Telomere Biology Disorders (#TBD) broadly — IPF, bone marrow failure, and more.

[Nature Aging @NatureAging]

Online now!✨Oppezzo et al therapeutically block telomeric DNA damage signalling to restore hematopoietic function in telomerase-deficient and aged mice, while reducing senescence and inflammation
@FdAdF66
@IFOMresearch https://t.co/7F6xZXDFa3

[Fabrizio d'Adda di Fagagna @FdAdF66]

Deep gratitude to @Fondaz_Telethon , @ERC_Research, @IFOMresearch, @CNRsocial_, @AGEIT_PE8 and all who supported this work.

[Fabrizio d'Adda di Fagagna @FdAdF66]

1/ What if some of the consequences of #aging are not caused by damage itself, but by the alarm signals our cells generate in response to that #damage?
Today, we publish a study in @NatureAging addressing this question.
https://t.co/KZJssN3br5

[Fabrizio d'Adda di Fagagna @FdAdF66]

8/ This journey is now continuing beyond academia.
https://t.co/Yutns0dJzP is advancing this approach toward clinical translation.