Fred Ehrsam

Co-founder @Nudge, @Paradigm, @Coinbase

[Fred Ehrsam @FEhrsam]

@lindaxie Lvl 60 undead priest

[Fred Ehrsam @FEhrsam]

@alexatallah Major congrats Alex. You followed your curiosity and it’s paying off!

[Fred Ehrsam @FEhrsam]

@joshim5 @chaidiscovery @Novartis ⚡⚡

[Fred Ehrsam @FEhrsam]

AI drug discovery has progressed from idea/open source to use at the largest pharma companies in the world in 2 years. What felt uncertain at seed seems inevitable today. Huge AI + bio acceleration. @chaidiscovery crushing on the commercial front!

[Jack Dent @jackdent]

I’m delighted to announce @chaidiscovery's collaboration with @pfizer. Their scientists will deploy our AI platform to accelerate drug discovery, including early access to our latest frontier model Chai-3.

You can learn more about this partnership and our momentum in @amyfeldman's feature in @Forbes out today

https://t.co/VBoynDgPCz

[Fred Ehrsam @FEhrsam]

Excited to serve on the President's Technology Council

[Director Michael Kratsios @mkratsios47]

Today, we welcome the first wave of extraordinary members to President Trump’s Council of Advisors on Science and Technology (PCAST).

Rooted in the tradition FDR began in 1933, PCAST unites America’s brightest minds to advise the President on the most pressing national issues in science and technology.

Under @POTUS, PCAST will focus on the opportunities and challenges that emerging technologies present to the American worker and how to best ensure the U.S. continues to lead in the Golden Age of Innovation.

Marc Andreessen
Sergey Brin
Safra Catz
Michael Dell
Jacob DeWitte
Fred Ehrsam
Larry Ellison
David Friedberg
Jensen Huang
John Martinis
Bob Mumgaard
Lisa Su
Mark Zuckerberg
https://t.co/1qXRuZNQ4M

[Fred Ehrsam @FEhrsam]

The human body is a multivariate system that is complex beyond what the human mind can comprehend. Computers will be able to understand and aid the body in ways humans never could. Biology textbook explanations will be looked back on as child-like oversimplifications.

[owl @owl_posting]

this is an essay about cancer, how it is one of the most 'detailed' diseases in existence, and why we must delegate the understanding of that complexity to machine intelligence

https://t.co/Gq2ikOpSXB

3.4k words, 15 minute reading time

[Fred Ehrsam @FEhrsam]

GLP-1s are the first of many trillion-dollar enhancement drugs that will begin as medical treatments

[Fred Ehrsam @FEhrsam]

The era of human enhancement

[Quintin Frerichs @quintinfrerichs]

There's a new kind of biotech company in silicon valley, the 'human enhancement company'. I believe this is the next new category of technology company to yield not only a >$100B household name, but to truly uplevel human health and wellbeing.

These companies are mission-driven, led by elite founders with high talent-density teams, well funded and focused on more than just treating health conditions. They're working on everything from portable read-write brain interfaces to turning stem cells into human eggs.

In 2020 there were ~0 great 'human enhancement companies', in 2025 there are ~5. I've been fortunate to spend the last couple of years co-founding and leading @nudge through its 0 to 1 trajectory, as well as investing in multiple others (@newlimit, @Conception). I think there are somewhere between 1-3 new companies of this quality to be founded in the coming few years, and the opportunity for each is enormous.

I am stepping down from my role at Nudge to work fulltime on investing in, incubating and building them. I'll continue to work closely with @FEhrsam to that end and to support Nudge in its mission. So excited about both where the company is today and building this ecosystem writ large.

[Fred Ehrsam @FEhrsam]

Every human living today will die by default. It’s extremely difficult to solve death. So it’s important to explore many solutions. Cryonics has potential to be a valuable tool. Glad to see @LauraDeming, who is extremely dedicated to this cause, get more resources.

[Until @untillabs]

We’ve raised $100M+ to date, we are developing reversible cryopreservation for patients in need of donor organs, and we are hiring 🫀🎉🚀

[Fred Ehrsam @FEhrsam]

@patrickc Especially as we try to build more advanced devices. Chips are the obvious canary in the coal mine. Which all policymakers have recognized as an emergency for years but somehow do not properly extrapolate.

[Fred Ehrsam @FEhrsam]

Work of art

[Poke @interaction]

Say hi to https://t.co/VIWYU64dUI! 👋🏼🌴

[Fred Ehrsam @FEhrsam]

@NeilEmil Ask them about their interests!

[Fred Ehrsam @FEhrsam]

Possible to get 80% of signal in an interview by going extremely deep on an arbitrary topic which (importantly) the interviewee prompts

[Fred Ehrsam @FEhrsam]

Chai marches on towards one shot AI drug design

[Joshua Meier @joshim5]

Proud to announce @ChaiDiscovery has raised a $70M Series A from @MenloVentures & Anthology Fund (@AnthropicAI), @ThriveCapital, @OpenAI + others.

🧬 Chai is an applied AI lab building frontier tools for molecular design.

This funding will power our new models, coming soon👇

[Fred Ehrsam @FEhrsam]

@pdhsu @nudge @quintinfrerichs Thanks Patrick!

[Fred Ehrsam @FEhrsam]

If you want to work on one of the hardest and the most consequential problem to humankind, reach out! https://t.co/uxoT9SqOVU

[Fred Ehrsam @FEhrsam]

We've raised a $100M Series A from @ThriveCapital, @greenoaks, and a host of great angels.

Everyone’s brain can work better. Engineering that idea into reality is the most impactful advancement we can make to life.

[Nudge @nudge]

Half the world will experience a brain disorder in their lifetime.

At @nudge, we're building brain interfaces that are safe, precise, and non-invasive to solve that problem.

We've raised a $100M Series A led by @ThriveCapital and Greenoaks to go faster.

We're hiring. Join us.

[Fred Ehrsam @FEhrsam]

Computers able to zero shot antibody discovery. Science fiction is becoming real.

[Chai Discovery @chaidiscovery]

We’re excited to introduce Chai-2, a major breakthrough in molecular design.

Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x.

Thread👇

[Fred Ehrsam @FEhrsam]

This is a classic dynamic in internet-based disruptions in other categories. Consolidate, transform, and expand.

[Fred Ehrsam @FEhrsam]

Stablecoins working at scale significantly accelerates crypto as the future of the financial system. All financial services will need to be (re)built for this ecosystem. This is a once in a generation platform shift. The major pillars of the future of finance are up for grabs.

[Fred Ehrsam @FEhrsam]

The potential rewards are tremendous. Crypto-based services can often operate globally, allowing them to reach scales not otherwise possible and far quicker, consolidating fragmented markets in the process.