Jack Dent

Co-Founder @chaidiscovery

[Jack Dent @jackdent]

@FEhrsam @chaidiscovery Thanks @FEhrsam! Paul said it right: https://t.co/0WpxCNFf7G

[Paul Wollenhaupt @pwolle_]

Miracles will become infrastructure

[Jack Dent @jackdent]

@gabepereyra @chaidiscovery 🫡

[Jack Dent @jackdent]

@vvkgopalan @chaidiscovery @pfizer Thank you! 🙏

[Jack Dent @jackdent]

I’m delighted to announce @chaidiscovery's collaboration with @pfizer. Their scientists will deploy our AI platform to accelerate drug discovery, including early access to our latest frontier model Chai-3.

You can learn more about this partnership and our momentum in @amyfeldman's feature in @Forbes out today

https://t.co/VBoynDgPCz

[Jack Dent @jackdent]

@lulumeservey @chaidiscovery @pfizer Thanks Lulu!

[Jack Dent @jackdent]

@byersblake @foundersfund @ThriveCapital @Greenoaks @QuietCapital Gradually, then all at once

[Jack Dent @jackdent]

Fun to sit down with my friend @SabrinaHalper and talk about Chai's journey. Thanks for having me on!

[Sabrina Halper @SabrinaHalper]

"We have this long term vision of turning biology from something which is trial and error and experimental and make it something that looks more like an engineering discipline in the next century."

New Episode with @jackdent !

0:00 Intro
02:28 Inside @stripe w/ @patrickc, at <100 People
08:45 @sama role in @chaidiscovery origin
16:20 Chai-2 Antibody Breakthrough
19:24 Approaching biology as an engineering problem
24:45 Using AI models to treat people on an individual scale
26:52 Robotics in labs
27:22 Pharma industry today
29:49 The clinical trial bottleneck
32:53 Personalized biology models & cancer vaccines
36:24 Longevity, peptides, and trillion-dollar drugs
39:02 Does it matter that the government cut exploratory science grants?
41:00 What next-gen Chai models will do
42:08 Can frontier AI labs build this themselves?
43:26 Biology is hard

[Jack Dent @jackdent]

@apartovi @neo Congrats Ali. Neo has cracked the code

[Jack Dent @jackdent]

@ypatil125 @apartovi @appliedcompute 🚀

[Jack Dent @jackdent]

@srikosuri @rhomsany Congrats! 🍾

[Zavain Dar @zavaindar]

Memo: What If We're Right?

We recently wrote a private letter to partners & friends of a common failure mode: the inability to consistently reason through the daisy chain of downstream consequence when non-consensus, low-probability, events actually occur

pages: 1-3

[Jack Dent @jackdent]

Grateful to share the stage with @robzirk and @BenjamineYLiu at PhRMA Forum today. We are at a critical inflection point for the industry. AI deployment is taking off, and 2026 will be the year get a glimpse of how it will transform the future of medicine.

[Robert Zirkelbach @robzirk]

Today at PhRMA Forum, I had the privilege of discussing the power of AI in health care with @jackdent and @BenjamineYLiu.

AI has the potential to transform drug discovery and development. Even just looking at the start of 2025 to today, the results of this new technology are unimaginable. AI is helping scientists design better medicines, eliminate bad ideas earlier and run faster clinical trials.

This is why it’s essential for America to continue leading in technology and biopharma innovation. We must do all we can to accelerate the next generation of treatments and cures.

[Jack Dent @jackdent]

@dps Congrats @dps! Have been excited about this since I got the sneak preview

[Jack Dent @jackdent]

@getCos @sidd @AccrualHQ Special people building a special company.

[Jack Dent @jackdent]

Great opportunity to work with some of the best in the business

[Pranav Reddy @pranavreddy]

applications for Embed now open, due 2/9

Embed is a Schelling Point for the best early stage founders. cash, compute, community, and a catalyst

past participants were dropouts, leading researchers and repeat founders. alumni have raised more than a billion dollars

links below

[Jack Dent @jackdent]

Great coverage from @xiaofei_lin on our deal with @EliLillyandCo and the start of the "year of deployment".

[Fay Lin, PhD @xiaofei_lin]

2026 has kicked off with a stream of AI platform deals across pharma, signaling a cultural shift away from single-asset bets and toward AI infrastructure for broad discovery.

@NOETIK_ai, @chaidiscovery, @boltz_bio

Read at @GENbio:
https://t.co/iK6dJF6bz3

[Jack Dent @jackdent]

@advait_m Thanks Advait!

[Jack Dent @jackdent]

I’m proud to announce Chai Discovery’s partnership with Eli Lilly to accelerate the discovery of next-generation therapeutics. Through this collaboration, we'll deploy our frontier models, train custom models on Lilly's proprietary data, and create an entirely new toolchain for discovering life-changing medicines.

[Chai Discovery @chaidiscovery]

We’re thrilled to announce our collaboration with @EliLillyandCo.

We’ll be deploying Chai’s AI models to power biologics discovery across a broad set of drug programs at Lilly.

This is a major step forward in pharma’s adoption of AI-native R&amp;D.

[Jack Dent @jackdent]

@ericjang11 Thanks @ericjang11! 🙏

[Greg Yap @grgyap]

Congrats to @joshim5 @jackdent @chaidiscovery on their first major deal announcement with Eli Lilly! Always amazing to see their pace to adoption. 2026 looks like the tipping point in pharma adoption of AI tools up and down the stack! https://t.co/LrzhR36pmv

[Jack Dent @jackdent]

@mattkrisiloff Thanks @mattkrisiloff!