johnny Fernando

[Ankur Sangoi @slusagar]

while we've had concurrent digital avail for past several years for routine🔬cases, only recently have we been able to have digital scans for the whole mount prostatectomies we do

nice #GUpath #grosspath correlation of prostate cancer

#makingprostatepathfunagain

[Janira Navarro @Janiranavarro]

When do you work up a triple-negative cancer in a breast core needle biopsy to rule out metastasis?

- When histologic features raise concern for non-breast origin, especially if there is no in situ carcinoma (sometimes this is a difficult distinction to make).
- All triple-negative cancers unless there is in situ carcinoma.

What stains do you do?
GATA3 is performed by >90% of breast experts, followed by SOX10, CK, TRPS1, and TTF-1 (pic 2).

Dr. Schnitt #USCAP2026 #pathology #PathX #PathTwitter

[Charlie Herndon @DrCycloPath]

✅ Tubulocystic Renal Cell Carcinoma 🎯🧬
• Exclusive tubulocystic growth of small to intermediate-sized tubules and cysts lined by a single layer of hobnail cells
• Eosinophilic cells display enlarged, irregular nuclei, prominent nucleoli, and abundant eosinophilic cytoplasm
• Characterized genetically by a consistent gain of chromosome 17 and losses of chromosomes 9 and Y
• Usually follows an indolent clinical course with an excellent prognosis, though rare metastases are documented

[International Society of Urological Pathology @IntSocUropath]

📢 ISUP Consensus Publications on Genitourinary Cancer Precursor Lesions Released! Congratulations to the ISUP Consensus Panel and contributing authors.

Direct links to WG articles in comments below. Archived publications linked here: https://t.co/dGOxyh1hpd

[Janira Navarro @Janiranavarro]

Classic features of patch mycosis fungoides

- Rete hyperplasia - skinny and fat rete
- Atrophy
- Epidermotropism without spongiosis
- Perinuclear halos
- Hyperchromatic, irregular, jagged lymphocytes
- CD4:CD8 increased at least 4.5:1

Dr. Junkins-Hopkins #USCAP2026 #pathology #PathX #PathTwitter

[Janira Navarro @Janiranavarro]

Lung
**Reactive pneumocytes vs malignant cells**

Reactive
- Spectrum of atypia
- Cytoplasmic vacuolization
- Maintained N/C ratios
- Cytology: Napoleon hat sign

Dr. Sauter #USCAP2026 #pathology #PathX #PathTwitter

[Everyday_Pathology @Pathology_Xever]

Pathology youtube channel : Pathology Community of Interest Meeting https://t.co/19E7FkyLCI

[Piero Hincapie @pierohincapie]

Oficialmente en mi segundo Mundial. Un orgullo inmenso representar a mi país ante el mundo. Gracias a Dios, a mi familia y a cada ecuatoriano por la confianza. ¡Vamos con todo, Ecuador! 🇪🇨🙏🏻⚽️

[Janira Navarro @Janiranavarro]

*Dogma-defying soft tissue tumors*

Not all EWSR1-WT1 fusion tumors are desmoplastic small round cell tumors (DSRCT)

There are unusual EWSR1-WT1 fusion-positive tumors with glomoid/myoid morphology, lacking desmoplasia, showing desmin/SMA positivity on IHC, and a favorable clinical prognosis.

Dr. Warmke #USCAP2026 #pathology #PathX #PathTwitter

[Janira Navarro @Janiranavarro]

New entities in soft tissue pathology

***FET-CREB fusion sarcomas***

Variable histology with epithelioid/round cells showing an odd combination of multiple aberrant markers (CK, EMA, MUC4, ALK, CD30, synapto , etc.) is valuable for screening FET-CREB sarcomas

Half of cases are intra-abdominal
Wide age range
Highly aggressive

Will be included in the upcoming BST WHO book

FET-CREB is an umbrella term for fusions between FET genes (mainly EWSR1, sometimes FUS) and CREB family transcription factors (CREB1, ATF1, or CREM)

Pitfall: Angiomatoid fibrohistiocytoma (AFH) and FET-CREB sarcomas have a similar genotype, but morphology differs and, most importantly, AFH mortality is >1% versus >50% in FET-CREB sarcomas

Dr. Agaimy #USCAP2026 #pathology #PathX #PathTwitter

[Dr Kamlesh Darji @DrKamleshDarji1]

https://t.co/ef4PIpYAH1

[MonicaGarciaBuitrago @MonicaGarciaBu2]

Masterclass with @manuel_lg on pulmonary small biopsies and cytology- Insightful pearls, beautiful cases, and an excellent reminder that morphology still matters🔬🫁@UMiamiPathology @MerceJorda1 @martin_poveda82 @asocolpat @JaylouVelez @CarmenGomezMD

[MonicaGarciaBuitrago @MonicaGarciaBu2]

Thyroid cytology session with @JaylouVelez: Bethesda categories, tricky cases, and practical pearls you can use every day🔬🧐 @UMiamiPathology @CarmenGomezMD @MerceJorda1 @martin_poveda82 @MI_FUCS #tiroides #thyroid @DePatologos @asocolpat @LatinAmericanPF #residents #path

[Janira Navarro @Janiranavarro]

Lung: Benign metastasizing leiomyoma

On CT, can present as nodules, solitary mass, cavitary or cystic lesions, and miliary pattern.

IHC positive: desmin, caldesmon, SMA, ER, PR, WT1; low Ki-67 index.

Largest published series: ~80% had a history of uterine leiomyoma; the other 20% had no history or unknown history of uterine leiomyoma.

Dr. Yi #USCAP2026 #pathology #PathX #PathTwitter

[Janira Navarro @Janiranavarro]

Thyroid
RAS-like: The follicular family
BRAF-like: The papillary family

Dr. Jung #USCAP2026 #pathology #PathX #PathTwitter

[The British Assoc of Gynaecological Pathology @BAGPGynPath]

#HilaryBuckleyAward Low grade endometrial stromal sarcoma with smooth muscle differentiation showing starburst pattern. 105 mm mass in uterus. Spindle cell nodules with radiating collagenous bands. <1mm from serosa. Positive for CD10, SMA. Negative Cyclin D1, Melan A #BAGP2026

[Janira Navarro @Janiranavarro]

Histopathologic Flavors of Metastatic Prostate Carcinoma - "Amphicrine"/prostatic adenocarcinoma with neuroendocrine expression

🔷Tumor cells simultaneously express both prostate and neuroendocrine markers (expression can be patchy)

🔷 High-grade carcinoma without definite small cell features (like Gleason pattern 5)

De novo amphicrine sample report (pic 2)
Treatment emergent PC sample report (pic 3)

Dr Chan #USCAP2026 #pathology #PathX #PathTwitter

[Janira Navarro @Janiranavarro]

***Histopathologic flavors of metastatic prostate carcinoma***

- Conventional prostate cancer (looks like prostate cancer and NKX3.1 positive, pics 2 and 3)
- Neuroendocrine prostate cancer
- "Amphicrine" / prostatic adenocarcinoma with neuroendocrine expression
- Undifferentiated
- Other morphologic variants

Dr. Chan #USCAP2026 #pathology #PathX #PathTwitter

[Dr Rupam Manna MD @DrRupamOncology]

🚨 2026 Melanoma Management Algorithm – Fully Updated!
The definitive practical guide for cutaneous melanoma is here.
Key 2026 update:
✅ Perioperative immunotherapy is now preferred for resectable macroscopic Stage III (clinically positive nodes, satellites/in-transit, nodal recurrence)
→ Neoadjuvant PD-1 ± CTLA-4 (or relatlimab) → Surgery → Response-adapted adjuvant therapy (NADINA + SWOG S1801)
Plus:
• Precise surgical margins & SLNB criteria
• BRAF-driven decision tree for Stage IV
• Brain mets, mucosal & uveal melanoma pathways
• Current preferred philosophy & landmark trials
Aligned with NCCN v2.2026 & ESMO 2025. Designed for real-world oncology practice.
Save this. Share with your team. Use it daily.
What’s your biggest takeaway from the new perioperative approach? Drop it below 👇
Follow for more high-yield cancer algorithms → @DrRupamOncology
#Melanoma #Oncology #Immunotherapy #NCCNGuidelines #CancerCare #MedEd

[Gerônimo Jr. @GeronimoJrLapac]

Recurrent Nevus - A Melanoma Mimic! 😲

#pathplus #pathology #dermpath