Fernando Gomez-Herreros Lab

DNA repair and Gene Expression in human disease. Andalusian research group. Find us at @IBiS_Sevilla

[Fernando Gomez-Herreros Lab @FGH_Lab]

New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". https://t.co/4EAgVmiRwH @ibis_sevilla @InvestigaUS

[Fernando Gomez-Herreros Lab @FGH_Lab]

Muy contentos y agradecidos de que el último trabajo del laboratorio haya sido seleccionado como artículo del mes por la @SEBBM_es !!🎉🎉 @ibis_sevilla @InvestigaUS

[SEBBM @SEBBM_es]

#ArtículodelMes

H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death
Por @Diana_Rubio_ et al.

https://t.co/rnmy9Jn8LD

[Cristian Prieto-Garcia @CristianPG_mlg]

Our Science paper is out! 😀 Enjoy if you like SPRTN, DPCs, Innate immunity and Aging.

https://t.co/ruO2EUeEks

[Diana Rubio @Diana_Rubio_]

Excited to see our research published!! 🎉

Amazing project in @FGH_Lab at @ibis_sevilla, @unisevilla

"H263A and SCAN1/H493R mutant TDP1 block TOP1-induced double-strand break repair during gene transcription in quiescent cells and promote cell death"

https://t.co/qzDHW7Y1En

[Fernando Gomez-Herreros Lab @FGH_Lab]

A terrific work of @diana_rubio and @hidalgogarciaD with the support of all the lab. @josefra1975 @E__GranadoCalle

[Fernando Gomez-Herreros Lab @FGH_Lab]

New manuscript from the lab on @cddpress " H263A and SCAN1/H493R mutant TDP1 block TOP1-induced Double-Strand Break Repair during gene transcription in quiescent cells and promote cell death". https://t.co/4EAgVmiRwH @ibis_sevilla @InvestigaUS

[Fernando Gomez-Herreros Lab @FGH_Lab]

These results support the potential role of TOP1-induced DSBs as a main contributor to certain hereditary neurological syndromes.

[Diario de Sevilla @diariosevilla]

Un estudio del Instituto de Biomedicina de Sevilla desvela un nuevo mecanismo de sensibilidad del sarcoma de Ewing a la quimioterapia #Sevilla #SevillaHoy https://t.co/DlpGkYUpzE

[Fernando Gomez-Herreros Lab @FGH_Lab]

Grateful to all collaborators who made this work possible!

[Fernando Gomez-Herreros Lab @FGH_Lab]

Our latest study is now online at @oncogenejournal https://t.co/PZfmCYBcwL A great collaboration between the @FGH_Lab and @LabHuvr labs, driven by the outstanding work of @olmedo_pelayoJ at @ibis_sevilla Check it out!

[Fernando Gomez-Herreros Lab @FGH_Lab]

👉EWS::FLI1 modulates R-loop metabolism via DHX9, driving increased vulnerability to TOP1-targeting agents.
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors

[Joaquin Olmedo @olmedo_pelayoJ]

Proud to announce that last Thursday I successfully defended my PhD thesis, “Understanding genome instability in Ewing sarcoma: from molecular mechanisms to novel therapeutic approaches”, at the @ibis_sevilla.

[Hana Sedlackova @HanaSedlackova1]

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! https://t.co/N643U0oS1M

[RosadoLab @RosadoLab]

Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs.

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances https://t.co/TzuVsSrQio

[Luis Lloredo Alix @llloredo]

Se ha filtrado el borrador de ley de universidades que está preparando la CAM. Si se aprueba, será la muerte de la universidad pública madrileña. Es escandaloso. No exagero. Se vienen tiempos oscuros como no espabilemos. Explico algunos puntos críticos. Va hilo. 👇

[Diana Rubio @Diana_Rubio_]

¡¡Premio Nacional de Juventud en Ciencia y Tecnología!! Gracias @InjuveSpain y @JuventudInfGob por dar visibilidad y reconocer la labor de los jóvenes investigadores en España. @ibis_sevilla @FISEVI_sevilla @FGH_Lab @InvestigaUS

[Fernando Gomez-Herreros Lab @FGH_Lab]

@NestorGarRod @unisevilla @cabimer Great news! Congratulations

[Millán-Zambrano @GMillanZambrano]

Have a look at our review in @MolecularCell . We explore how histone modifications serve as integrators of genome activity, mediating communication between distinct DNA procesess. https://t.co/Oz8quwj7uv

[Molecular Cell @MolecularCell]

Dynamic histone modification patterns coordinating DNA processes https://t.co/qFvZCRutaw

[Fernando Gomez-Herreros Lab @FGH_Lab]

Posting now in @fgh-lab.bsky.social as well