FireInABottle

Thinks about biology

[FireInABottle @fire_bottle]

The new series at Fire In A Bottle has begun!!

This is my attempt at tying together the threads. PUFA, oxygen, the Cambrian explosion, antioxidants. Copepods. Starting in my back yard.

https://t.co/jKmYDwpYEG

[FireInABottle @fire_bottle]

This is an interesting question.

1) NEVER lump n3 together. Linolenic acid (flax) is NOT handled in the body like EPA/DHA from fish oil
2) MANY experiments in mice/rats show that EPA/DHA reduces expression of lipogenic enzymes dramatically

[exfatloss🥛 @exfatloss]

Every time I actually try fish for more than a couple of days, I slide closer to the Peat interpretation: all PUFA is bad, even omega-3.

Just quit the salmon experiment after only 14 days.
- Way worse weight loss than beef
- Sunburn
- General sense of food not being satisfying
- Increased appetite for heavy cream
- Didn't feel quite 100% much of the time ("malaise?")

Maybe it's a dose-makes-the-poison thing and the correct dose is "no more than 1-2 fish meals a week?"

[FireInABottle @fire_bottle]

@lauramatsue @LatinaRanting Are you a witch? Be honest.

[FireInABottle @fire_bottle]

This is madness. We spread myths that body type is about calories-in-calories-out. Then someone has a kind of gaunt look therefore they must be doing something like anorexia.

I have friends with this same look and I can assure you they eat very well! https://t.co/pVugdjsuz3

[FireInABottle @fire_bottle]

@exfatloss Hey, I LIKE PHP!!

Or I did at one point.

[FireInABottle @fire_bottle]

@exfatloss But probably also plastic and PFAS.

[FireInABottle @fire_bottle]

@exfatloss @LoschbourStev No!!! If you look close you can see that those are buildings and Silos. AKA bankruptcy tubes. It’s where farmers would keep their silage. They’re like giant sauerkraut fermenters, except with grass or cornstalks rather that whatever.

[FireInABottle @fire_bottle]

@exfatloss @BowTiedWoodwork They’re made out of WOOD!!

[FireInABottle @fire_bottle]

@exfatloss Right. Could be some clues there.

I wonder what happens if you fill out the contact form? Probably nothing.

[FireInABottle @fire_bottle]

@KetoCarnivore @Leo_Abstract @TuckerGoodrich @sudas1891 @exfatloss @MeTheAngryCat @603_4me @siobhan_huggins Regardless of where one stands on deep evolutionary philosophy, PPARa metabolism and circadian rhythm are co-regulated….

https://t.co/WGLuKm9Smo

https://t.co/9gfohOMXEK

[FireInABottle @fire_bottle]

@KetoCarnivore @exfatloss @TuckerGoodrich @sudas1891 @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins I should have said: clofibrate is a pharmaceutical that activates D6D. I really should have responded to this post instead:

[L. Amber O'Hearn @KetoCarnivore]

@sudas1891 @TuckerGoodrich @exfatloss @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins @fire_bottle Well, Volek and Phinney did report lower D6D in KD mice, despite membrane levels of HUFAs increasing in them (and in KD humans).

OTOH PPAR-α (a signature of KD) increases D6D, and KD increases blood levels of DHA and ARA.

(Slide from my RDA talk)

[FireInABottle @fire_bottle]

@KetoCarnivore @exfatloss @TuckerGoodrich @sudas1891 @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins The other major factor is PLA2. PLA2 releases the ARA from the SN-2 position of the phospholipids. It is normal to see high conversion to ARA via D6D/D5D but low membrane levels because the ARA is being released and converted to oxylipins.

https://t.co/qsHMfQfpPU

[FireInABottle @fire_bottle]

@TuckerGoodrich @sudas1891 @exfatloss @KetoCarnivore @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins D6D is controlled by PPARa and is increased by PPARa agonists. So diets high in oleic acid (via OEA) and ALA give the highest D6D activity, although oxidized n6 PUFA ultimately contribute to the positive feedback loop.

https://t.co/STt5MB5q1R

[FireInABottle @fire_bottle]

@KetoCarnivore @exfatloss @TuckerGoodrich @sudas1891 @Leo_Abstract @MeTheAngryCat @603_4me @siobhan_huggins Remember that D6D and D5D are right next to each other in tight linkage dysequilibrium.

So if you get the HI active D6D, you get the LO D5D (genetically). These people have higher DGLA: LA is rapidly converted to DGLA but the DGLA is slowly converted to AA by D5D.

[FireInABottle @fire_bottle]

@TuckerGoodrich @sudas1891 @Leo_Abstract @exfatloss @KetoCarnivore @MeTheAngryCat @603_4me @siobhan_huggins This is actually the idea. Torpor = increased D6D and SCD1.

PUFA goes down and MUFA goes up.

I don’t see how this connects to oxidative risk. Body temp drops to near freezing, oxygen levels are controlled/low. Not much oxidative risk.

[FireInABottle @fire_bottle]

This seems as good a place as any to plug https://t.co/S9YhDqhzEm

[Sudās @sudas1891]

@Leo_Abstract @TuckerGoodrich @exfatloss @KetoCarnivore @MeTheAngryCat @603_4me @siobhan_huggins @fire_bottle Biology boils down to redox it seems. Fuck redox up and you fuck with cellular energy production

[FireInABottle @fire_bottle]

@exfatloss @kattakastali @dPeeri @siobhan_huggins @trikomes It’ll be very niche until it’s not.

[FireInABottle @fire_bottle]

@exfatloss @kattakastali @dPeeri @siobhan_huggins @trikomes Yeah. I think that’s right.

[FireInABottle @fire_bottle]

@exfatloss @kattakastali @dPeeri @siobhan_huggins @trikomes I’m probably 2-3 months out. Coming soon.