Klein Lab

Laboratory of Experimental Immunology @UKKoeln - studying the antibody response to HIV-1, HCV, HCMV, SARS-CoV-2 and other infectious pathogens

[Uniklinik Köln @UKKoeln]

Gründungssymposium des Centrums für Infektionsmedizin (CIM): Das CIM der #Uniklinik #Köln bündelt Sachverstand in der Infektionsmedizin. Gearbeitet wird an Best-Practice-Modellen für Patientenversorgung, translationale Forschung & Aus- und Weiterbildung. https://t.co/pP43t67q5d

[Leif Erik Sander🇺🇦 @Sander_Lab]

Wir freuen uns auf dieses spannende Projekt gemeinsam mit @LabSchultze @FKlein_Lab @fabian_theis @marylyn_addo @HeroldLab @MartinaSester @alena_buyx u.v.m. zu cutting edge KI #SwarmLearning in der klinisch-immunologischen Forschung am Bsp. von COVID19.
Danke an @VolkswagenSt

[Klein Lab @FKlein_Lab]

@UK_Frankfurt @CiesekSandra Fantastic news and Congratulations Sandra! This is very well deserved!

[Klein Lab @FKlein_Lab]

@SchommersP @EKFStiftung @UKKoeln Fantastic! Congratulations Philipp!

[Else Kröner-Fresenius-Stiftung @EKFStiftung]

Die drei Else Kröner #ClinicianScientist Professuren 2023 erhalten ...
PD Dr. Natascha Köstlin-Gille, @uniklinik_hd
PD Dr. Dr. Philipp Schommers, @UKKoeln u.
Dr. Jonas C. Schupp, @MHH_life
Herzlichen Glückwunsch! 🥳
@jonas_schupp @SchommersP #EKFS
➡️ https://t.co/17aIYiALhX

[Uniklinik Köln @UKKoeln]

Wie verändert sich die Antikörperantwort gegen #SARSCoV2 mit der Zeit und wie bereitet sich das Immunsystem mit klugen Strategien auf neue Varianten vor? Die AG von Prof. Klein @FKlein_Lab hat dazu Studien in @ImmunityCP und @SciImmunology veröffentlicht. https://t.co/4KJnc9hNTJ

[Klein Lab @FKlein_Lab]

Previously acquired bystander mutations can increase B cell diversity against variants.

Transferring a single bystander mutation restores the neutralizing activity of tixagevimab against BA.1/BA.2.

[Klein Lab @FKlein_Lab]

We are very happy to share our latest publication out in @ImmunityCP! Here we investigated how somatic hypermutation impacts SARS-CoV-2 neutralizing antibodies (https://t.co/ZGNwb8OkDQ).
Thanks a lot to our dear 🇮🇱 friends and collaborators @DiskinLab

[Klein Lab @FKlein_Lab]

Highlights include:
A fraction of mutated antibodies neutralizes Wu01 independently of the acquired mutations.

Germline VH1-58 mAbs neutralize Alpha, Beta, and Delta but require mutations for BA.1/BA.2.

[Klein Lab @FKlein_Lab]

Congratulations Elena, Eva, and Rolf!

[Uniklinik Köln @UKKoeln]

Patient von #Leukämie und #HIV geheilt: Für die Heilung des „Düsseldorfer Patienten“ wurde ein interdisziplinäres Forschungsteam mit Beteiligung von Forschenden der #Uniklinik #Köln heute mit dem Preis der Deutschen #Hochschulmedizin 2023 ausgezeichnet. https://t.co/5Uu6DMDMX2

[Klein Lab @FKlein_Lab]

Congratulations Timm, Sabrina, and Svea to shed light on how #SARS-CoV-2 vaccination and breakthrough infections shape our antibody response. Now @SciImmunology. Thanks to all study participants and co-authors!

https://t.co/kOPrF4AFM3

[Klein Lab @FKlein_Lab]

@c_gaebler @ChariteBerlin Fantastic and well deserved! Congratulations Christian!

[Universität zu Köln @UniCologne]

🎉🏆Sieben Forschende der #UniKöln sind unter den meistzitierten Wissenschaftler*innen weltweit 🌍. Herzlichen Glückwunsch an unsere zwei Biolog*innen und fünf Mediziner, die zu den einflussreichtsen 1% ihres Faches gehören. 🧪🩺
#HighlyCited2023
Mehr 👇 https://t.co/G8V3SgOiUb

[Klein Lab @FKlein_Lab]

Excited to share our latest publication @ImmunityCP: "Analysis of the Human B Cell Response to HCMV in Top Neutralizers from a cohort of 9,000 Individuals"!
Congrats to @zehner_matthias, @Ashurov_Art and Mira and thanks to all collaboration partners!
https://t.co/VaVYPbdFYa

[Klein Lab @FKlein_Lab]

Just out: Our study on the dynamics of HIV-1 neutralization in over 2.300 individuals @NatureMedicine. Congratulations to Philipp (@SchommersP) and thanks to all our collaboration partners from around the world.

https://t.co/Rfo6iQACn6

[Klein Lab @FKlein_Lab]

Congratulations Christoph, Cosimo and Seda! Thank you very much Aleksandra Walczak, Thierry Mora, Andreas Beyer and all other co-authors for this great collaboration!

[Christoph Kreer @ChristophKreer]

Happy to share the publication of our joined project between @FKlein_Lab and the Walczak/Mora Lab, where @wolphysics, Seda and myself investigated the probabilities of developing HIV-1 neutralizing antibody sequence features: https://t.co/YwjUzvrBjm

[Christoph Kreer @ChristophKreer]

Happy to share the publication of our joined project between @FKlein_Lab and the Walczak/Mora Lab, where @wolphysics, Seda and myself investigated the probabilities of developing HIV-1 neutralizing antibody sequence features: https://t.co/YwjUzvrBjm

[Christoph Kreer @ChristophKreer]

Check out how we applied our @FKlein_Lab antibody isolation workflows to target drug resistent bacteria in this fantastic cooperation with @SimonisLab, @JanRybniker and @DZIF_ colleagues…

[Klein Lab @FKlein_Lab]

We are happy to announce that our lab is the first on campus @UKKoeln to be awarded the highest level of certification (Green) by @My_Green_Lab!
https://t.co/2kBBi9yrYu

[Klein Lab @FKlein_Lab]

Excited about #AntibodyBasedTherapies workshop of the @DZIF_ bridging topic hosted @UKKoeln. Amazing talks by representatives from academic research, clinic & industry all coming together to advance the development, production & clinical testing of monoclonal antibodies.