Flaherty Lab

Lab of Daniel Flaherty, Ph.D. Associate Professor of Medicinal Chemistry and Molecular Pharmacology at Purdue University.

[Flaherty Lab @FlahertyLab]

First author J. Med. Chem. paper released and defending your PhD on the same day?! That’s a great day @Katrina_Holly98!

Very proud of our newly minted PhD from the lab!

[Flaherty Lab @FlahertyLab]

New paper out today from @Katrina_Holly98 and Prabhakara Rao Tharra on their work on development of bacterial carbonic anhydrase inhibitors against vancomycin-resistant Enterococci. They produced an analog with oral efficacy rescuing mice in a septicemic peritonitis model.

[ACS Publications Bio & Med Chem Content @ACSBioMed]

Bacterial carbonic anhydrase inhibitors with improved PK and efficacy in VRE septicemia mouse model. #JMedChem @flahertylab @DrugDiscoveryPU @Purdue_MCMP

https://t.co/ZFUkOLWs6w

[Flaherty Lab @FlahertyLab]

So proud of @Purdue_MCMP and @FlahertyLab grad student @molly_youse for successfully defending her PhD today! She did an amazing job and we are super excited for her next steps in her scientific career!

[Flaherty Lab @FlahertyLab]

Very proud of @Purdue_MCMP grad student and lab member @molly_youse for being awarded the Jenkins-Knevel Award for Outstanding Graduate Research! This is the highest honor in the Purdue COP for grad research. Very well deserved!

[ACS Publications Bio & Med Chem Content @ACSBioMed]

Design strategy from @FlahertyLab yields improved solubility for AC1 inhibitors with in vivo efficacy in rat model for inflammatory pain. #JMedChem

https://t.co/5I3kKUXM7q

[Caroline Ng @nglab_malaria]

Our postdoc position is still open! #malaria #ubiquitin #proteasome #protein degradation #UPR #artemisinin #resistance #drug resistance

[Flaherty Lab @FlahertyLab]

This project in collab with Dr. Val Watts and @Purdue_MCMP grad student @tiffany_summerr has gone from hit identification to through two manuscripts. The current scaffold had solubility liabilities and we took an approach to break up the molecular planarity to improve solubility

[Flaherty Lab @FlahertyLab]

Our newest paper led by Dr. Shri Annadka presenting modifications on the pyrimidinone scaffold to improve solubility and AC1 inhibition with a new lead molecule with efficacy in a rat model for inflammatory pain.

https://t.co/qHklMmWCyf

[ACS Publications Bio & Med Chem Content @ACSBioMed]

New ethoxzolamide analogs from @FlahertyLab show improved PK properties and efficacy in mouse model for gonococcal infection. #JMedChem

https://t.co/ZpznFCDKLl

[Flaherty Lab @FlahertyLab]

Our new paper from @Purdue_MCMP grad student @molly_youse is out. Molly designed new analogs of Ethoxzolamide with improved PK properties and anti-gonococcal activity leading to molecules with oral efficacy in a mouse model for N. gonorrhoeae infection.

https://t.co/ITj2cwCcTn

[Flaherty Lab @FlahertyLab]

New paper from the lab led by @Purdue_MCMP grad student @Katrina_Holly98 in collab with Groshong lab at NIAID Rocky Mountain Laboratories. Targeting the oligopeptide transport system in B. burgdorferi.

https://t.co/Ge1LgpxV2E

[Flaherty Lab @FlahertyLab]

@Hopkins_Lab @Super70sSports Used this pen during O-chem in college. The prof would switch between dry erase marker colors and you would hear the whole class click the pens to switch colors 😂

[ACS Publications Bio & Med Chem Content @ACSBioMed]

Covalent UCHL1 inhibitor with crystal structure and anti-metastatic properties from @FlahertyLab @WendtLab_Cancer @KesslerlabOx

Read in #JMedChem here ➡ https://t.co/JDA18mA04T

[Flaherty Lab @FlahertyLab]

New paper from the lab covalently targeting UCHL1. Great collab with @WendtLab_cancer @kesslerlabox and Das Lab @ClydeDadChitta! Screening, med chem, crystallography, Ub-proteomics, cellular activity all come together to tell the story. @Purdue_MCMP

https://t.co/Rpb4llYIdE

[Flaherty Lab @FlahertyLab]

@DuerfeldtLabs Awesome job to the team!

[Flaherty Lab @FlahertyLab]

Purdue @Purdue_MCMP grad student @molly_youse was awarded 1st Place in the Poster Competition at the 2nd Annual Antimicrobial Resistance Conference for her work in lead opt/studying small molecule properties that affect accumulation in Neisseria gonorrhoeae! Congrats!

[Flaherty Lab @FlahertyLab]

@TheRileyLab Congrats Andrew! Great news.

[Flaherty Lab @FlahertyLab]

@AubeLabUNC Thank you Jeff. A lot of folks have supported me on this path including yourself. It means a lot.

[Flaherty Lab @FlahertyLab]

@DuerfeldtLabs Thanks Adam! Means a lot.

[Flaherty Lab @FlahertyLab]

I am honored to receive this title. Thank you to Chip and Jane Rutledge and to @purduepharmacy for the support!

[Purdue Pharmacy @purduepharmacy]

Chip and Jane Rutledge have a history of impactful service to Purdue. The duo shares a passion for supporting early career faculty that inspired them to endow a new professorship. Daniel Flaherty is the inaugural recipient. Full story: https://t.co/v1deDdSvIu #pharmacysgiantleap