Kessler Group Oxford

Mass Spectrometrists at the Target Discovery Institute, University of Oxford

[Matthias Mann Lab @labs_mann]

China clearly sees the potential of proteomics and is about to place a gigantic bet on it; multi-billion dollar and 30 years!!! All the better for the advancement of science and health. We contributed to the white paper out now in @Nature
https://t.co/480tmOJQ3C

[CAMS Oxford Institute @CAMS_COI_Ox]

A new paper from @kesslerlabox details how to profile a protein's molecular environment. Check it out here...

[Kessler Group Oxford @kesslerlabox]

Want to profile your favourite protein's molecular environment? Here a detailed APEX2-based protocol applied to spatially resolve the NLRP3 inflammasome @Zhu_L_Oxford @AndreasDamiano2 @flassen_ @ProteomOX @CAMS_COI_Ox @CmdOxford https://t.co/PJMcM7wwKK

[Kessler Group Oxford @kesslerlabox]

Looking for E3 / PROTAC / glue or DUB / DUBTAC substrates? Proxy-Ubiquitomics might be the way - applied here to USP30 @AndreasDamiano2 Hannah Jones @ProteomOX
https://t.co/4VV75YCGTK #biorxiv_molbio

[Kessler Group Oxford @kesslerlabox]

@JonSilk2 @Caroline_Bartma @vineethvengayil @BenediktKessler Constitutive protein degradation via PROTACs may contribute to acute cell death via proteolysis products https://t.co/HzWI9PeDsE

[Nuffield Department of Medicine @NDMOxford]

BPGbio and NDM’s @CmdOxford have announced a research collaboration focused on advancing novel #ProteinDegradation technologies with the goal of unlocking new therapeutic pathways for conditions with limited treatment options.

Find out more 👉 https://t.co/Too9t7mvC4

[Ivan Đikić @iDikic2]

One of the most exciting expert session with students/postdocs at the #EMBOubiquitin2024 conference in #Cavtat. Careers, publishing, crazy ideas in science, spiked with table football and beach discussions/swimming. Thx to all for participating 🫶😊 #ubiquitin @YMerbl

[Kristijan Ramadan Laboratory @Kramadan2]

Study discovers new process for cells to repair DNA damage https://t.co/yXtRwOUugn

[Kessler Group Oxford @kesslerlabox]

Nucleophagy molecular details revealed by @ProteomOX - great collaboration with @Kramadan2 @VdangioE3lab @OxfordOncology @CMD

[Kristijan Ramadan Laboratory @Kramadan2]

Congratulations to our DPhil student Pauline Lascaux, all our lab members, and collaborators worldwide @NTUsg @NTU_LKCMedicine @OxfordOncology @institutrb @VdangioE3lab @nunoraimundo on the role of nucleophagy in DNA repair. Please check: https://t.co/vgIe0n8SXE

[biorxiv_biochem @biorxiv_biochem]

USP24 is an ISG15 cross-reactive deubiquitinasethat mediates IFN-I production by de-ISGylatingthe RNA helicase MOV10 https://t.co/JAUBx4HUsy #biorxiv_biochem

[Adán Pinto Fernández @adanpinto]

Preprint alert 🚨 . Another great collaboration with Aysegul Sapmaz and Paul Geurink in Leiden. This time we identified and characterised USP24 as a deISGylating enzyme with roles in IFN-I production and potential use as an antiviral target. #ubiquitomics

[Ivan Ahel Lab @IvanAhelLab]

Our new paper demonstrating reversible ubiquitylation of DNA and RNA:

https://t.co/1fV1WI7I0q

[Kessler Group Oxford @kesslerlabox]

@IvanAhelLab Expanding the Ubiquitin Code: E3s/DUBs control nucleic acid ubiquitylation - nice collaboration with the @IvanAhelLab

[CAMS Oxford Institute @CAMS_COI_Ox]

@adanpinto has been awarded a prestigious 2-year grant from @Boehringer. Find out more here: https://t.co/kb8WdYU30L

[Kessler Group Oxford @kesslerlabox]

Congrats @adanpinto 🎉

[CAMS Oxford Institute @CAMS_COI_Ox]

@adanpinto has been awarded a prestigious 2-year grant from @Boehringer. Find out more here: https://t.co/kb8WdYU30L

[Kessler Group Oxford @kesslerlabox]

Novel DDR #ubiquitin MOA based on CRISPR & Proteomics Discovery @ProteomOX

[Vincenzo DAngiolella @VdangioE3lab]

Our latest manuscript on a new cell cycle dependent control of dna repair. Started from a high resolution crispr screen of #ubiquitin system after IR: check table S2!
Also substrates of cyclin f through motif search!
https://t.co/foGAoXwwu7

[Adán Pinto Fernández @adanpinto]

Yesterday, we bid a fond farewell to Beatrice. As she continues her journey towards completing her DPhil, we’ll greatly miss her passion for research, dedication, and vibrant spirit in the lab. Best of luck Beatrice!

[Erin Humphries @ErinMHumphries]

Looking for a sample preparation method for FFPE tissue proteomics and phosphoproteomics? Check out our latest paper which compares a range of deparaffinisation, rehydration and extraction methods. Link: https://t.co/dgADK3yKEz

[Kessler Group Oxford @kesslerlabox]

Spearheaded by @adanpinto @Sapmaz_A @darraghpobrien & Jin Gan

[Adán Pinto Fernández @adanpinto]

Excited to share this editorial on non-canonical ubiquitination [https://t.co/se2TaodGV9…]. Huge thanks and congrats to my amazing co-editors and co-authors @Sapmaz_A, Jin Gan, and @darraghpobrien and all the contributors to this research topic! #Ubiquitin #Ubiquitomics

[Kessler Group Oxford @kesslerlabox]

Athina's farewell lunch🍹with many speeches 💬 Great job working with @AndreasDamiano2 @Zhu_L_Oxford