we did it 👏🍾🎉🕺💃☺️
today was last visit of the last patient of the TTVguideIT study
260 KTX recipients randomiced to torque teno virus 🦠 guided immunosuppression vs SOC and followed for one year
thanks to all 13 recruiting centers across europe #ttvguide
Self-reported non-adherence to immunosuppressive medication detected by the BAASIS predicts allograft rejections in kidney transplant recipients
https://t.co/XN9zj2Yf3q
Torque Teno Virus–guided monitoring of immunosuppressive therapy
🆓https://t.co/HsrzuazvwF
➡️This is a promising & innovative strategy for monitoring the status of the immune system in solid organ transplantation as well as autoimmune, infectious & oncologic diseases
Florina Regel presents a multicenter cohort study to analyse the value of donor proteinuria on kidney graft quality
🇦🇹 Transplant Congress
- do we need such assessment?
- is uPCR better than semi-/qualitative measures?
pharmacy refill records are easy to implement in ehealth records 📈
can they detect medical 💊 non adherence in kidney TX recipients?
new data from the AdTorque study from Sebastian Kapps at the 🇦🇹 Transplant Congress
Felzartamab is safe in ABMR post kidney TX and might be a new therapeutic option
we see rebound after stopping it
what happens if we give a prolonged tretament?
Katharina Mayer at the 🇦🇹 TX congress
today we had the month 42 project meeting of our EU funded RCT to test the value of torque teno virus 🦠 guided immunosuppression
the TTV qPCR works like a clockwork 😊 #ttvguide @biomerieux
Today‘s highlight: the initiative @ChariteBerlin , where patients & experts discuss relevant topics around kidney transplantation! 🎗️Making research accessible to our patients is key! @ttvguidetx @NephroIntensivB
novel mechanism for imune evasion by TTV suggested by @MedUni_Wien center for virology 👏👏👏
1. TTV stabilises HLA E on infected cells
2. -> expansion of NKG2A receptors on T cells
3. -> less IF gamma production
https://t.co/nZD86cNBbg
#ttvguide@AberleJudith
we will have an old school poster walk in London with drinks, nibbles and lots of good conversations 😊
poster will be printed as sustainable as possible 😀
see you soon!
torque teno virus 🦠 guided immunosuppression
today we randomiced our last patient in Vienna @MedUni_Wien for the TTVguideIT trial #ttvguide
🙏 to @fredhaupenthal, stephan steinringer, sebastian kapps and the whole Vienna study team 😀
The potential of TTV monitoring to be an "Immunometer"🧭🦠 after organ transplantation and in autoimmune, infectious and oncologic diseases. #ttvguide
Happy to share this editorial overview! 👏 SebastianKapps @BondGregor@NDTsocial@ttvguidetx
Presented at #ERA24:
In this phase 2 randomized trial, the CD38 monoclonal antibody felzartamab showed acceptable safety and promising efficacy among patients with chronic antibody-mediated kidney-transplant rejection. Read the full trial results: https://t.co/S6wvGwoQqB