Time to Change the Treatment Paradigm - No More Needles in the Eye
It's 2025, and we have an alternative to the pain faced by millions of wAMD and DME patients - an at-home subcutaneous administration once per month that treats both eyes, dramatically reducing the need for the need for needles in the eye without ocular OR systemic safety issues.
Very exciting to be releasing the Phase 2 data on Saturday, Feb 8!
Ashvattha is the first therapeutics platform to target and reprogram macrophage and microglia (two important immune cells) which are known to be responsible for neurological disorders to cancer, ophthalmic diseases to autoimmune disorders.
We're excited to partner with @tribecap and @arjunsethi for our $50M Series B extension.
Thankful to @NatCapCentral for their support since our incubation! /1
Checkpoint inhibitors only work in 15-40% of patients who have cancers. They are miracle drugs but could use some help. @AshvatthaTx has developed a radiopharmaceutical that can solve the problem.
HDTs are made from drug-dendrimer conjugates and in four health volunteer safety studies and 2 Phase 2 studies we find repeated safety in human subjects some of whom have been dosed chronically for forty weeks. This is exciting for us and patients who could benefit from our drug pipeline for Wet AMD/DME, Chronic Fatigue Syndrome/ME, solid tumors (targeting tumor associated macrophage), Multiple Sclerosis.
A hydroxyl dendrimer, the basis for all our drugs and the entire class of HDTs (hydroxyl dendrimer therapeutics), of which we have 32 in our pipeline. Every generation 4 dendrimer has 64 hydroxyl arms that can be loaded with the same or different active molecule making for a potent drug platform.