Jay Z

Building the future @NatCapCentral, Cofounder & President @AetherMachines, Board @AshvatthaTX prev: Partner @SocialCapital, @CloudOnInc / @Dropbox

[Jay Z @superjz]

Are you solving the below problems with the solution set of the 2020s and 2030s? Would love to partner with you. #discover

[Jay Z @superjz]

Are you a scientist, engineer, designer, technologist or entrepreneur that wants to solve the world's hardest problems? Would love to partner with you to solve these ~40 problems by 2045. #discover https://t.co/63uBkuFAG7

[Max Marchione @maxmarchione]

In some very real sense, Ozempic was invented in 1990. Pfizer ran the human trials and just never published them.

They showed it lowered blood glucose in diabetics, slowed gastric emptying, and killed hunger; the same 3 things that make Ozempic work today.

The joint venture agreement said internal data stayed internal, and that was that. Pfizer killed the program in 1991. The reasoning, as far as I can tell, was that nobody would ever want an injectable diabetes drug besides insulin.

So, the license went back to the hospital in Boston that held the patents.

Novo picked it up in 1992 and spent the next two decades building liraglutide, then semaglutide.

It's insane that data sat in a filing cabinet for 30+ years.

I only know this because Jeffrey Flier, one of the Harvard scientists in the room, finally wrote it up. He's in his late 70s and didn't want the history to die with him.

This makes you wonder what else is in those filing cabinets.

Ozempic could've existed 27 years ago.

[Oliver Cameron @olivercameron]

Introducing Agora-1, a world model that's learned to simulate multi-agent experiences. It's so fun.

Today we're launching a playable research preview, where you can relive your childhood and enjoy a multiplayer simulation of GoldenEye.

So excited about this new capability!

[Odyssey @odysseyml]

Introducing Agora-1, a multi-agent world model.

Multiple participants—human or AI—can now interact inside the same world simulation, all in real-time.

Try our playable research preview today, with Agora-1 simulating a multiplayer GoldenEye deathmatch!

[Oliver Cameron @olivercameron]

We're also releasing an accompanying technical report of Starchild-1, to share our learnings and encourage further research in this direction!

[Oliver Cameron @olivercameron]

Introducing Starchild-1 from @odysseyml, the first ever real-time multimodal world model.

This a model that can generate interactive simulations of the world that you can—for the first time ever—hear.

Starchild-1 represents a big step towards a general-purpose world simulator.

[delian @zebulgar]

Anthropic's run-rate? ~$60b

Keytruda's run-rate? ~$25b

Keytruda is just ONE drug which was improved in microgravity

[delian @zebulgar]

https://t.co/nF604EZ5x1

[Oliver Cameron @olivercameron]

In Minecraft, PROWL dramatically improved world model performance across physics, visuals, action following, and long-horizon consistency.

A really promising lever of scale for world models.

[Oliver Cameron @olivercameron]

What if world models could learn by discovery?

Today we’re sharing PROWL: RL agents that explore game environments, simulators, and eventually robots to discover failures in a world model.

This loop of learning is fully automated!

https://t.co/QNaTBw68XJ

[Odyssey @odysseyml]

Introducing PROWL!

We’ve built RL agents that explore game environments, tasked with discovering failures in world models across physics, visuals, and actions.

Those failures then become training data in an automated loop that advances world model performance.

[Jay Z @superjz]

@pmarca @Alex_Danco 👀

[Odyssey @odysseyml]

It’s time to go beyond language models.

Introducing Odyssey-2 Max, our most powerful world model yet. It materially advances the SOTA in physical accuracy.

This is a big step toward models that simulate and interact with the world in real time.

A new intelligence entirely!

[Narendra Modi @narendramodi]

Today, India takes a defining step in its civil nuclear journey, advancing the second stage of its nuclear programme.

The indigenously designed and built Prototype Fast Breeder Reactor at Kalpakkam has attained criticality.

This advanced reactor, capable of producing more fuel than it consumes, reflects the depth of our scientific capability and the strength of our engineering enterprise. It is a decisive step towards harnessing our vast thorium reserves in the third stage of the programme.

A proud moment for India. Congratulations to our scientists and engineers.

[Jay Z @superjz]

GPS was designed 50 years ago, and the world has outgrown it. Signals are weak, unencrypted, easily jammed. American farmers literally use Russian and Chinese satellites because GPS isn't enough. I’m excited to partner with Mark Scheinberg and the Mohari Ventures team to lead the $170M Series C round in @XonaSpace. Having incubated @SwarmInternet at Social Capital and followed the satellite market for over a decade, I believe Brian Manning, Tyler Reid and the team at Xona are solving GPS with the urgency, speed, and scale that space infrastructure demands. Xona's Pulsar satellites fly 20 times closer to Earth and deliver signals 100 times stronger, bringing centimeter accuracy with no new hardware required. Psyched to once again partner with @skydayton on this one.

Special thanks: @RTanuku, David Zelouf, Darren Cohen

Read Brian's past here: https://t.co/5oR7vOFb90

[Natural Capital @NatCapCentral]

Congrats @RTanuku @krakenfx @tribecap on the launch of a successful $KRAQU! 💙

https://t.co/yfOnnaACBZ

[Ravi Tanuku @RTanuku]

Excited to announce KRAKacquisition Corp. (KRAQU)—a SPAC formed in partnership between @NatCapCentral , @krakenfx, and @tribecap, where I serve as CEO.

Throughout history, speculation has catalyzed lasting innovation: Dutch East India shares created equity markets. Grain futures built the Chicago Board of Trade. Junk bonds opened mid-market capital access.

The same pattern is unfolding in digital assets. Over $240 billion in private investment since 2016. 650M+ users globally. Stablecoins settling $136B+ in payments. What began as speculation is now crystallizing into infrastructure.

We're focused on companies building the convergence of DeFi and TradFi—payment networks, tokenization platforms, blockchain infrastructure, compliance solutions. Companies ready to scale in the public markets.

Fortunate to partner with @mooredant, @brevsin , and independent directors @artzandy, @bendavenport , @JReedRosenthal , and @nikichain.

Special thanks to: @superjz @arjunsethi @LaurenP0ST @LunaPRofficial

[Hemant Taneja @htaneja]

This is not politics as usual. As investors, innovators, leaders, and citizens, we need to come together to preserve our democracy, the rights set forth in our country's Constitution, and our shared humanity. All of these serve as the foundation for our modern society, human progress, and innovation.

What we are seeing in Minnesota is a threat to those core tenets and to the promise of America. Without confidence in the fundamentals -- human rights, the legal process, and the privilege and responsibility of our government and its leaders to protect all people -- the future is at stake. That impacts all of us here in the U.S., and globally.

[Vinod Khosla @vkhosla]

I agree with @EthanChoi7 . Macho ICE vigilantes running amuck empowered by a conscious-less administration. The video was sickening to watch and the storytelling without facts or with invented fictitious facts by authorities almost unimaginable in a civilized society. ICE personnel must have ice water running thru their veins to treat other human beings this way. There is politics but humanity should transcend that

[Mgoes (bio/acc 🤖💉) @m_goes_distance]

Biotech is fvcked.

Not because the science is dead, the business model is backwards.

Just this week:
> Lyra Therapeutics laid off all 28 employees. 7 years of work. Multiple clinical trials. Still had $22.1M left -enough runway until Q3 2026
> Lucy Therapeutics shut down after 7 years. Backed by Bill Gates and the Michael J. Fox Foundation. $42M raised. Promising animal data. Never made it to human trials

Meanwhile ~$17B has flowed into AI drug discovery since 2019, but 1000s of startups later, not a single AI‑discovered novel drug has reached approval.
That isn’t a science failure. It’s structural.

VCs like to chase AI narratives. And that's the problem.

The solution is simple: fund clinical execution.

[Jay Z @superjz]

Verbatim from the paper: India, “the country of a hundred nations and a hundred tongues, of a thousand religions and two million gods” (Twain, 1897/1989, p. 348), has the largest mean regional diversity of these populations (CFST = .11)

Also, from the paper:
Many readers will be familiar with the cultural differ-
ences within the United States—the honor culture of
the South (Nisbett & Cohen, 1996), the corporate and
educational culture of New England, the liberal culture
of the West Coast, and so on (Woodard, 2011)

This basically says there is no "single cultural trait" called Western Culture. Sweden and Norway are further out culturally from the United States than India.