Although all 4 trials were done in relapsed myeloma with 1-3 prior regimens, the type of patients varied including by type of prior exposure. So comparing head to head HRs is not advisable.
Patient and disease factors, access, affordability, and shared decision making come into play, especially in first relapse. In second relapse we have to also add belantamab. https://t.co/rMu8MdadmL
MonumenTAL-3 is out in NEJM 🍾
https://t.co/2xxas0h4TL
Tal-dara-pom and Tal-dara offer superior PFS and OS over DPd. Tal-based combos are a new SOC in 2line + RRMM
Congrats to the study team and the co-authors!
@PlasmaCellPete@mbeksac56@gdnsvl@paurotero@mvmateos
DRVD—ASCT—-DR x 2 years (may continue Len till month 36 but will then stop) or enroll in @CCTG MY.13. Upon relapse go to Tec/dara. I will likely be retired by the time pts relapse off first two lines :) @MyelomaCanada I need tec/dara asap.
My summary of CARTITUDE4, MajesTEC3, MajesTEC9 and MoumenTAL3. In anti-CD38 refractory patients and EMDs -->TCE anti-BCMA or anti-GPRC5D are >> to Cilta-Cel
CAR-T is not dead!
Bispecifics & CAR-T are highly effective. CAR-T allows pts to hv Tx free time while pts are on continuous Rx w/ bites. Both require supportive care for infxn prevention. And yes, rare toxicities are there w: ciltaacel that we need to study & find answers.
Just wrapped up an amazing IMWG summit in Stockholm.
17th year in a row. We saw 17 new myeloma drugs approved in these 17 years.
“The Plasma Cells” honored our Kyle and Durie award winners @H_Einsele@NoopurRajeMD this year as usual with some fun songs. And @JoshuaRichterMD closed it out with a killer guitar solo.
From left: @szusmani@paurotero Francesca Gay, Philippe Moreau, Sonja Zweegman, Niels van de Donk, @mvmateos Enrique Ocio, @SurbhiSidanaMD@VincentRK@JoshuaRichterMD
And at #IMFIMWG26, Mr. New York takes on “Hotel California”…
And not just crushes it, he knocks it to MRD neg at 10^-8 in 30 seconds 👏
Bravo @JoshuaRichterMD for 🎸 performance of the year!
@drdibakarpodder@Bethfaiman@arunva5407@AjHematology I think 4 mg/kg is a great idea! Really cool concept and work by Hamadeh @szusmani et al looking at this concept…
we need more dose optimization work in this space especially for high-cost supportive care with bsAbs 👏
https://t.co/TbRM3RKsMI
En route to 🇸🇪 via 🇨🇦 for #IMFIMWG25 - I am wolfing down my dinner after a delayed ✈️ connection, meanwhile @HiraSMian looks ready to lead a session as always!!
Now we’ll just see if this flight lands on time… looking forward to meeting many global collaborators again!
I’m heading to the 17th Annual IMWG Summit— one of the most amazing meetings in medicine. It is a working meeting where we gather to discuss and brainstorm all things myeloma. It is one of a kind meeting. It is Team Work at its best!
Team work in myeloma has in part been made possible by strong informal leadership, and respect for each other that we share. The kind where one phone call can solve any problem or misunderstanding. The kind where researchers, patients, pharmaceutical companies, and non-profit organizations have truly come together for a shared goal and vision.
We debate and argue. With 20 new drugs approved in 20 years, the myeloma field has a lot to talk about! But our collective vision is to improve survival and to cure myeloma. We stay focused on that and tune other stuff out. At the start of every IMWG summit we say it doesn’t matter who gets the credit as long as we help myeloma patients. And we mean it.
I have been in the field for over 25 years and I know what we have in myeloma is unique. The Annual IMWG summit organized by @IMFmyeloma epitomizes this team work.
Patient advocates & orgs gather this week for the 2026 Global Myeloma Action Network (GMAN) Summit. GMAN's mission: elevate myeloma awareness, enhance patient care, & expand global treatment access. Together, we can shape a brighter future for patients worldwide!
#IMFGMAN#mmsm
Members of the IMWG come together for the 2026 IMWG Summit to discuss key issues related to myeloma treatment. This group of global experts collaborates to create globally recognized consensus guidelines to improve outcomes for the myeloma community. #IMFIMWG@szusmani
LIVE FROM #ASCO2026: Educational Session - Smoldering Myeloma: To Treat or Not to Treat by @NBahlis and @AjayNookaMD :
"To treat all High Risk patients also in daily practice!" @DottorClaudio from @IRSTDinoAmadori one of the most expert and active reseaerchers in Myeloma Prevention
#myeloma #multiplemyeloma #smolderingmyeloma #smm
MAJESTEC-9 trial at #ASCO26 : the message was strikingly simple: a couple of curves summarized it all. At the end, curves speak louder than words. @TheIACH@COMyCongress