Ganesh Kashim

Stay Hungry, Stay Foolish

[Pawan @PawanKChandana]

It’s been 24 hours now…

Vikram-1’s launch still feels surreal.

Knowing just how hard this is, I couldn’t contain the excitement at Mission Control as the rocket we built with so many dreams successfully inserted satellites into orbit — on its very first attempt.

Just phenomenal! 🔥🚀🚀

[Massimo @Rainmaker1973]

4 billion years of human evolution unfold in minutes

[🎞️ thebrainmaze]

[ICC @ICC]

𝐓𝐇𝐑𝐄𝐄-𝐓𝐈𝐌𝐄 𝐂𝐇𝐀𝐌𝐏𝐈𝐎𝐍𝐒 🏆

A milestone home #T20WorldCup triumph for India 🙌

[Ganesh Kashim @ganeshgane]

@aiwithmayank Agents

[Bryan Johnson @bryan_johnson]

I’d cancel your AG1 subscription. They just completed a clinical trial and the results show no clinical benefit. 

This has been obvious for years.  AG1 has no real product substance and is fundamentally an influencer heist.  

Two simple alternatives (75% and 56% less $), outperform AG1 in randomized clinical trials.

Two simple mono-ingredient alternatives that outperform AG1:

1. Chicory inulin 12 g daily ($20/mo)
2. Resistant starch 30 g daily for 12 weeks ($35/mo)

AG1 is not worth $79/mo.

AG1 study results (4-weeks, N=30):
+ No significant changes in blood biomarkers compared to placebo (CBC, CMP, lipids).
+ No statistically significant improvement in digestive quality-of-life scores (p = 0.058).
+ No significant metabolic or inflammatory biomarker benefits of any kind within the scope of what was measured in the trial.
+ Only small shifts in microbiome taxa but clinically irrelevant at this stage.
+ The intervention did not increase microbiome diversity compared to placebo. Alpha diversity was unchanged, and the taxa changes seen were only from pre- to post-analysis within each group. Between-group differences were limited, and the placebo actually showed similar or even potentially larger shifts. This means the observed changes fall within normal placebo-driven variability, not a real treatment effect. No global microbiota shifts were detected.

Chicory inulin 12 g in constipation patients
+ 12 g of chicory inulin daily for 4 weeks (compared to maltodextrin placebo)
+ Global microbiota shifts: enrichment in butyrate-producing Bifidobacterium and Anaerostipes, and depletion of the pro-inflammatory Bilophila.
+The effect was seen by comparing intervention vs placebo in a cross-over setting, a very rigorous type of clinical analysis in which each person serves as their own control, eliminating a lot of individual random noise.
+ The trial also met its primary objective by improving constipation symptoms in the targeted patient group.

Resistant starch daily 30g for 12 weeks in older adults
+ Significant increase in Bifidobacterium in both middle-aged and elderly participants, with an increase in the beneficial microbiome byproduct butyrate, and reductions in Proteobacteria (including inflammatory Escherichia–Shigella) in the elderly.
+ Resistant starch also significantly reduced blood glucose, and produced greater reductions in blood insulin and insulin resistance (HOMA-IR) in the elderly group.

[Elon Musk @elonmusk]

Tour of the Starship factory

[Curiosity @CuriosityonX]

🚨: After 48 years of travel, NASA 's Voyager 1 is nearing one light-day from Earth, almost 16 billion miles away.

A proud milestone for humanity, and a humbling reminder of how small we are in an infinite universe.

[BCCI @BCCI]

5⃣0⃣9⃣ Intl matches
2⃣4⃣,2⃣0⃣8⃣ Intl runs
4️⃣8️⃣ Intl centuries

Winning Head Coach of ICC Men's T20 World Cup 2⃣0⃣2⃣4⃣ 🏆

Here's wishing #TeamIndia great Rahul Dravid, a very Happy Birthday 🎂🥳

[Nithin Kamath @Nithin0dha]

Nik has been on a roll, and for someone who started ~50 episodes ago and does it as a side gig, he has really improved over time. Full pro-podcaster he has become. 😀

Goes on to show that the odds of success are much higher when you build things around what you love.
@nikhilkamathcio is curious, looks good, listens, and speaks well, and the magic sauce is launching the podcast at the right time when podcasting in India was just taking off.

The thing that stood out to me was what @elonmusk said beautifully towards the end of the podcast, and also describes much of what Nik does with WTF, which I’m proud of as a brother.

“I’m a big fan of anyone who wants to build. Anyone who aims to make more than they take has my respect. That’s really the core principle: strive to be a net contributor to society.
It’s similar to the pursuit of happiness. If you want to create something valuable or financially successful, the goal shouldn’t be the money itself. Instead, focus on providing genuinely useful products and services. When you do that, the financial rewards tend to follow naturally. Just like happiness—you don’t chase it directly; you pursue the things that lead to it: fulfilling work, learning, friendships, loved ones. The happiness is a byproduct.
It might sound obvious, but anyone starting a company should expect to work extremely hard, accept that there’s a real chance of failure, and stay focused on ensuring that the output is worth more than the input.
Are you creating value? That’s what matters. Make more than you take.”

[Ganesh Kashim @ganeshgane]

@RaviShastriOfc @grok What happened two years ago?

[ICC @ICC]

𝐂𝐇𝐀𝐌𝐏𝐈𝐎𝐍𝐒 𝐎𝐅 𝐓𝐇𝐄 𝐖𝐎𝐑𝐋𝐃 🇮🇳🏆

India clinch their maiden Women’s @cricketworldcup title at #CWC25 🤩

[BCCI Women @BCCIWomen]

𝐂.𝐇.𝐀.𝐌.𝐏.𝐈.𝐎.𝐍.𝐒 🏆

Congratulations to #TeamIndia on winning their maiden ICC Women's Cricket World Cup 🇮🇳

Take. A. Bow 🙌

#WomenInBlue | #CWC25 | #Final | #INDvSA

[Ganesh Kashim @ganeshgane]

@simonmaechling H

[Sridhar Vembu @svembu]

On Arattai, we have initiated discussions with Sharad Sharma of iSpirt, the group that did the technical work to make UPI happen, to standardize and publish the messaging protocols. I am a huge fan of UPI and hugely respect the work the team did. Sharad is a good friend and he will guide us in this objective.

These systems need to be interoperable like UPI and email and not closed like WhatsApp today. We do not want to be a monopoly ever.

We are committed to that goal and we will work with iSpirt to make this happen.

[Sridhar Vembu @svembu]

There are questions about where Zoho is developed and where the data is hosted and who hosts it. There is a lot of false information we want to correct.

1. All the products are developed in India. Our global headquarters is in Chennai and we pay taxes in India on our global income. As a global corporation headquartered in India, we have offices in over 80 countries and have a strong presence in the US which is a big market for us.

2. Indian customer data is hosted in India (Mumbai, Delhi and Chennai, soon Odissa). We have over 18 data centers globally and they host the respective country or regional data. We are committed to hosting each country data in their own jurisdiction.

3. All our services run on hardware we own and software frameworks we developed, on top of open source like Linux OS and Postgres database.

4. We do not host our products on AWS or Azure. Arattai, specifically, is not hosted on AWS or Azure or GCloud. We use some of those services for regional switching nodes to speed up traffic but data is not stored in them. We are adding many such "points of presence" (POPs) as we speak.

5. Our Zoho Developer account in the App Store and Play Store lists our US office address because the account was registered in the very early days of those stores by one of our employees in the US just to test them out. We never changed that.

We are proudly "Made in India, Made for the World" and we mean it🙏

[Ganesh Kashim @ganeshgane]

@elonmusk lol 😂

[Always Keep Learning @AlwaysKeepL]

16 Mental Models

[Ganesh Kashim @ganeshgane]

@deedydas Pharma companies will have to suck it up. High time this changed.

[Ganesh Kashim @ganeshgane]

@jsaideepak @ShivAroor @AdityaRajKaul @sushantsareen @UnSubtleDesi @mountain_rats @Manik_M_Jolly @sidhant @Vikspeaks1 @braddy_Codie05 @TheLegateIN @major_pawan Much needed!

[Ganesh Kashim @ganeshgane]

@elonmusk @grok explain this video