gcaussade

Serial software entrepreneur; seed investor with active role in investments.  Healthcare, AI, cybersecurity,and compliance. Mentor start-ups. PMP, CISSP

[gcaussade @gcaussade]

@KyleMau What u say is true in some places, but not true at all in many if not most. We have high-speed trains all kinds of things. Also that get you from one place to another without much hassle or expense.

[Bryan Johnson @bryan_johnson]

Breaking news for people who want to look hot, be young and not die. 

A few years ago, two college dropouts told me they could accelerate longevity by building a faster AI chip. 

I invested, and they just pulled it off.

What it means:

> 10x more throughput (tokens per second) for the same power footprint

> Dramatically lower operational costs for executing today’s frontier models

> Run far larger, more capable AI models within the same power and thermal budget, because a transformer-specific chip spends a fraction of the energy per token that a general-purpose GPU does

Rob and Gavin's approach resonated with me because solving aging is a gigantic combinatorial search problem. The chemical space of small, drug-like molecules has around 10^60 possibilities.

These compounds need to be mapped against a human proteome derived from 20,000 genes, including 1,600 transcription factors, and a dense web of interactions among them. 

The size of the combinatorial space is problematic. You need to identify which targets to modulate, within specific cellular lineages, at exact dosages, and in optimal temporal sequences.

Traditional high precision physics simulations are too slow to brute force the problem. You can shortcut it with AI inference, using frontier neural networks as hyper fast surrogate models to predict biological interactions instantly. By hardwiring transformer logic into silicon, Etched offers the infrastructure needed to run these massive biological foundation models at scale.

I'm surprised and impressed they were able to pull this off, and so quickly. 

They already have $1B in orders

[gcaussade @gcaussade]

@SevNootyD @davidpattersonx Wow, what a bunch of incels

[gcaussade @gcaussade]

@craigstolarczyk @davidpattersonx Yea, wow, he's bizarre.

[gcaussade @gcaussade]

Being married to a beautiful intelligent MD, psychiatrist for 15 years that was empathetic, but new boundaries was a blessing. I suggest you learn more about human nature. She was far more intelligent and wise than you in many topics. That is bat crazy to say women shouldn't vote. Wow!

[gcaussade @gcaussade]

@Siddharth87 @t_blom And so what does that do for you? You've developed in a day so now someone else can create a competing product in a day?

[gcaussade @gcaussade]

It depends on your definition. If you are extremely secure, you can be vulnerable. That's the whole point. Some people use vulnerability in ways that they really mean manipulation? I work in the startup space and mentor a lot of startup entrepreneurs. Many have created support groups and they make themselves vulnerable to each other letting them know about their fears, etc. that's vulnerability not pretending to be perfect. Most of them are brilliant, and you have to be courageous to be truly vulnerable

[gcaussade @gcaussade]

They're post confuses me I'm a fan of Elon Musk but the changes they made with Doge early on were stupid. He knows it and the administration knows it. They were still learning, and changes hard and there are side effects every time you make it. When you're working at a government level almost every decision you make can kill people. They've learned their lessons and now they're finding real waste in Medicaid Medicare and that's something that needed to be worked on for a long time.

[gcaussade @gcaussade]

They're not there yet for serious work. But they're getting there. Every few months we keep hearing claims that they finally are good to use. Not yet. For simpler processes sure, for complex work even the frontier models outside of fable, etc level still struggle. It should be very interesting in 3 to 6 months though.

[gcaussade @gcaussade]

I've lived in several countries and they're all different but there are definitely some you don't want to live in, lol. Although I found if you have a lot of money you can almost live well anywhere. Costa Rica was fantastic for plenty of time and I love my property there but it has its own issues and I prefer the US for work reasonsIt's heaven in so many ways. Hard to compete with Southern France or Italy. :) I love London actually. The international flavors wonderful. Love Paris. Yeah I guess you're right :-) but the United States has become very difficult actually. A lot of Americans don't want to admit that the violence has become ridiculous.

[gcaussade @gcaussade]

Exactly 🤣. I live in the US but I'm European as well and I'm there yearly to visit family. Definitely interesting to visit the United States and see the huge gas stations and cheap food. But then Europeans find out that they can't afford healthcare, drugs are everywhere, you're more likely to die from a drug overdose than anything else if you're under 50. But, still a big fan of the US because if you're an entrepreneur you really can get the most done here. But it's at a huge cost to society and families.

[gcaussade @gcaussade]

@JuliaEMcCoy Nice

[Massimo @Rainmaker1973]

A recent study has demonstrated that continuous exposure to rose essential oil through inhalation can lead to measurable increases in gray matter volume in the human brain.

In this randomized controlled intervention, 50 healthy women participated: 28 in the experimental group applied rose essential oil to their clothing daily for one month, while 22 in the control group used plain water. Before and after the period, researchers used magnetic resonance imaging (MRI) to assess changes in brain structure. The results indicated a significant increase in gray matter volume (GMV) across the whole brain, with a particularly notable effect in the posterior cingulate cortex (PCC)—a region involved in memory processing, self-referential thinking, and emotional regulation. No significant changes occurred in areas like the amygdala or orbitofrontal cortex.

The olfactory pathway likely explains this effect: aromatic compounds from the rose oil travel directly to the limbic system, providing sustained stimulation that may promote neuroplasticity and help counteract age-related brain atrophy. The authors suggest this could have implications for dementia prevention, as the PCC is among the regions affected early in conditions like Alzheimer's disease.

This appears to be the first evidence that prolonged scent inhalation can induce structural changes in the adult human brain.

[Kokubun, K., et al. (2024). Continuous inhalation of essential oil increases gray matter volume. Brain Research Bulletin, 208, 110896. DOI: 10.1016/j.brainresbull.2024.110896]

[gcaussade @gcaussade]

Very good point. One of the most eye-opening things was years ago when I found out the low level with activity that coal puts out. By the way, with all the talk about coal it's pretty funny that one of our side projects is doing solar with Peabody coal. Even the coal companies are doing solar!

[gcaussade @gcaussade]

@erloesung @bswud Fascinating

[gcaussade @gcaussade]

@ku_ds17868 @pmarca We are currently creating new jobs with them but curious what new jobs do you see being created?

[gcaussade @gcaussade]

What you are describing is definitely someone who's neurodivergent. Someone on the ADHD spectrum will have certain amounts of that. I have a certain type of ADHD there are many different types and I have the hyper focus so I have a bit of that. But, Elon, and my late wife has a psychiatrist was an expert on this end did diagnose it; is far on the spectrum and there's a lot of anxiety associated with being on the spectrum. Not being able to shut down your mind is a bit of a curse and Elon pretty eloquently if that's the word you want to use describes it! He's learned to use it to become successful and help mankind. But it's very challenging and many turn to drugs to be able to deal with the anxiety

[gcaussade @gcaussade]

Marc benioff recently posted some things that ring true colon Elon is positioning himself as having tools with less guardrails. And frankly I've run into that as well, it is nice to have a system that lets you do actual work. I would never underestimate Elon. He has a huge amount of real world data

[gcaussade @gcaussade]

@quxiaoyin Not true at all. Yet again an example of user error.

[gcaussade @gcaussade]

Absolutely, it's unbelievable how much bad advice these big companies received early on. AI helps experts it does not replace them! (Yet)

[Rohan Paul @rohanpaul_ai]

Ford’s AI push hit a hard limit: factories still need human failure memory.

They hiring back 350 specialists to catch failures machines missed.

Ford leaned on automated inspection to find defects faster, but car manufacturing is full of edge cases where tiny design, material, supplier, and assembly changes interact in ways rules-based systems and trained models can miss.

The missing ingredient was tacit engineering knowledge, the hard-earned pattern memory built from many product cycles, failed parts, supplier mistakes.

Ford’s rehired “gray beards” now review designs before parts reach the plant floor, while also helping improve the training data behind the AI systems.

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independent. co .uk/tech/ford-ai-automation-human-workers-b3003787.html