DrMG

MD, PhD, Rheumatologist, Physiologist, University of Strasbourg, researcher in Myositis and Sarcopenia

[Iago Pinal-Fernandez @DrIagoPinal]

Excited to share our latest @ARD_BMJ study! We reveal the mechanism by which autoantibodies enter cells, disrupt their target autoantigens, and drive tissue injury and inflammation in myositis and other autoimmune diseases. 🧬

https://t.co/nbX62hRSb6

[Iago Pinal-Fernandez @DrIagoPinal]

🧬🚨New in @medrxivpreprint: Spatial transcriptomics reveals mechanism of autoimmunity driven by internalized autoantibodies: antibody secreting cells induce antibody internalization, disrupt autoantigen function, and drive muscle damage and inflammation

https://t.co/3ewfZxgd7k

[Iago Pinal-Fernandez @DrIagoPinal]

Autoantibodies can enter living muscle cells—and in myositis, this internalization may drive disease. A new Autoimmunity Reviews (2025) article from @raphaelakirou highlights emerging mechanisms and therapeutic implications of this paradigm shift.
https://t.co/zb9M8tcT45

[@Myositis_Strasbourg @Myositis_Stras]

💡Thrilled to share our latest article in @eular_ARD resulting from a collaboration between our group and Gilles Laverny's group (Metzger's team) @IGBMC 💪
✅Proteasome overactivation is a new hallmark of dermatomyositis and a promising therapeutic target!
PMID: 41058389

[DrMG @giannini85]

2025 Eular Barcelona
Great overview on HOw to Treat inflammatory myopathies (HOT), by Pr Alain Meyer @Myositis_Stras @CHRUStrasbourg @CRBS_Strasbourg @ern_reconnet

[DrMG @giannini85]

Glad to share our latest publication @giulia_qur @Myositis_Stras
https://t.co/40MAVSkBpp.…
Anti-HMGCR antibodies drive the pathogenesis of anti-HMGCR IMNM!

[DrOlivierBoyer @DrOlivierBoyer]

🔥 New insights in immune-mediated necrotizing myopathy #IMNM 🔥

Congrats @giannini85
@Myositis_Stras for showing that autoantibodies inhibit enzyme function of #HMGCR

https://t.co/vjcgv7VMwJ

@ACRheum @eular_org @TheMyositisAssc @Myositis_India @iuis_online @FOCISimmunology

[DrOlivierBoyer @DrOlivierBoyer]

Interested in #myositis?

Don't miss the special issue of @clinexprheum

https://t.co/bxXX4vKD02

[DrMG @giannini85]

@Myositis_Stras

[DrOlivierBoyer @DrOlivierBoyer]

Editorial @clinexprheum on from the International #Myositis Society (iMyoS) 

https://t.co/K8gCtDuZ31

 @TheMyositisAssc @Telethon_France @CureIBM @UKMyositis @Myositis_India @eular_org @ACRheum

[DrOlivierBoyer @DrOlivierBoyer]

Editorial @clinexprheum on from the International #Myositis Society (iMyoS) 

https://t.co/K8gCtDuZ31

 @TheMyositisAssc @Telethon_France @CureIBM @UKMyositis @Myositis_India @eular_org @ACRheum

[DrOlivierBoyer @DrOlivierBoyer]

Do not misdiagnose and underestimate the frequency of #myositis.

@TheMyositisAssc @CureIBM @Myositis_India @UKMyositis @Myositis_KI

[Filière de santé FAI²R @contactfai2r]

📄 Trajectoires d'activité de la maladie au cours de la #dermatomyosite juvénile de l’enfance à l’âge adulte 👤 Résumé par Dr Margherita GIANNINI (@giannini85) et Pr Alain MEYER ➡️ À lire sur : https://t.co/hJOxJaQGl7 #DMJ #maladiesrares #FAI2Ralupourvous #fsmr

[DrOlivierBoyer @DrOlivierBoyer]

IFNg kills mitochondria in #autoimmunity #myositis. Happy to share our latest publication.

@sfiimmunologie @LabWaggoner @TheMyositisAssc @DrIagoPinal @ingrid_lundberg @Immunopaedia @iuis_online @i_yakoub_agha

[Gilles Laverny @GillesLaverny]

Have a look at our new preprint from the talentuous @giannini85 about the generation of a new model of experimental myositis

[ENMC @_ENMC]

Are you the next mentee of 2024? @_ENMC Mid-Career Mentoring Programme. Deadline July 1st!

For more information and how to apply: https://t.co/k8Hi7KZm6B

#ENMC #ENMCMentoringProgramme

[Cure IBM—Inclusion Body Myositis @CureIBM]

The COVAD studies are large, international studies that have provided valuable information about autoimmune diseases. The COVAD-3 survey is now open and seeking volunteers. If you have inclusion body Myositis, please participate.

https://t.co/kiMyMt4F8m

[Delphine Mignot Richer @DelphineRicher]

2 jeunes🧍‍♀️talentueuses du @CRBS_Strasbourg auditionnées lors des Prix de thèse de la @socbiolstrasbg
Après Rana Smaida, Margherita Gianni nous a parlé des myopathies inflammatoires.
@IGBMC @Inserm @CNRS_Alsace #unistra

[Gilles Laverny @GillesLaverny]

Congratulations @giannini85 you can be proud of the accomplished work 😊

[DrMG @giannini85]

@GillesLaverny Thank you very much Gilles !

[DrMG @giannini85]

@RheumJnl @CHRUStrasbourg @CRBS_Strasbourg @DebrutL @Myositis_Stras

[@Myositis_Strasbourg @Myositis_Stras]

-> Prevalence of sarcopenia in IM with low or no disease activity: 18%
-> Whole-body DXA and hand-grip dynamometer: useful tools to assess damage in IM
-> Irisin and osteonectin may play a role in IM damage pathogenesis
Check our latest publication:
https://t.co/tSjldGB0OJ

[@Myositis_Strasbourg @Myositis_Stras]

-> Prevalence of sarcopenia in IM with low or no disease activity: 18%
-> Whole-body DXA and hand-grip dynamometer: useful tools to assess damage in IM
-> Irisin and osteonectin may play a role in IM damage pathogenesis
Check our latest publication:
https://t.co/tSjldGB0OJ