GloerichLab

Molecular cell biology lab exploring the role of mechanical forces in epithelial homeostasis and cancer @UMCU_CMM

[GloerichLab @GloerichLab]

Paper alert! β-catenin forms condensates that help build cell–cell adhesions - showing its role goes beyond simply linking E-cadherin to α-cat/actin.

Great collaboration with the @Jschuije lab. Congrats to 1st authors @JooskeMonster & @ManzatoCaterina!

https://t.co/nWrBDoqN1v

[GloerichLab @GloerichLab]

Many thanks to all collaborators (including
@cperezgonzalez, @DMVlab, @vanRheenen_Lab,
@Snippertlab) and the Dutch Cancer Foundation @kwf_nl for making this work possible!

[GloerichLab @GloerichLab]

Excited to share our new paper on mechanical forces regulating stem cell plasticity in colorectal cancer, involving force transduction via mechanosensitive calcium channels! https://t.co/jMh0TvgY6u

[GloerichLab @GloerichLab]

In future work we hope to unravel how TRPV4 and integrins cooperate to control YAP signaling in CRC cells, and how mechanical forces intersect with other cues controlling CRC cell plasticity

[GloerichLab @GloerichLab]

@godinho_susana @_LisaDonker @wellcometrust Awesome!! Congrats Lisa!! 🍾

[Kris DeMali @KrisDemali]

The 2023 Cell Contact and Adhesion Gordon Research Conference (GRC) is coming up next June. This has been the premier meeting at the intersection of cell adhesion, mechanobiology, cell signaling, and their relevance to development and disease.

[GloerichLab @GloerichLab]

Good times with our friends @Huveneers_Lab

[Huveneers Lab @Huveneers_Lab]

Gloerich/Huveneers labs retreat

Having fun and discussing new epithelial and endothelial mechano-science!

[Buzz Baum @BaumBuzz]

Are you curious? Do you want to explore the unknown? Do you want to delve into our origins? Are you an extremophile-phile? Do you want to work in the fabulous LMB? Do you BioRXIV? Do you like scones & ride a bike? If your answers to some of these are yes, come join us @lab_baum

[GloerichLab @GloerichLab]

@Jor_Ferreir @CellReports @_LisaDonker @UMCU_CMM @XavierTrepat Thanks and yes, let's definitely catch up soon! Great to see our papers coming out the very same week!

[GloerichLab @GloerichLab]

Our paper on a mechanical G2 checkpoint is out now @CellReports, in which we describe how epithelial cells sense when to divide
https://t.co/Z8XiFE3lXs

Great work from @_LisaDonker and everyone that contributed from our lab @umcu_cmm and @XavierTrepat and Borghi labs!

[GloerichLab @GloerichLab]

@margariddantas @JCellBiol Great to see this out! Big congrats!!

[GloerichLab @GloerichLab]

This mechanical checkpoint establishes a pool G2-halted cells in dense epithelia, which are readily triggered to divide when intercellular forces increase, for instance upon wounding - and thus coordinates cell divisions with cell loss

[GloerichLab @GloerichLab]

These cell density-dependent forces are transduced to the cell cycle by mechanosensitive E-cadherin adhesions via regulation of Wee1 and downstream Cdk1, thereby controlling G2 length and timing of mitotic entry