Hugo Snippert

Cancer biology. Research lab at UMC Utrecht & Oncode Institute. More an explorer than a researcher.

[Hugo Snippert @Snippertlab]

Very excited to share 3D Live-Seq. Integrated live-cell imaging and single-cell DNAseq of the same tumor #organoids. We reconstruct evolving tumor genomes over multiple consecutive cell divisions to map the tempo and patterns of karyotype diversification https://t.co/FPGaP48eck

[Hans Clevers @HansClevers]

1) Excited to share a ms entitled: Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D #organoid sheets. It describes an alternative to #Matrigel
https://t.co/97jLdmRYHe A thread:

[Van Rheenen Lab @vanRheenen_Lab]

New publication alert🚨🚨🚨Mechanisms that clear mutations drive field cancerization in mammary tissue is out @Nature https://t.co/z4qZwpV7uu Congratulations all for this great team work! 🎉

[Jens Puschhof @JensPuschhof]

Big milestone for our group @EMIL_DKFZ @DKFZ:
We are thrilled to be among the recipients of an ERC Starting Grant from @ERC_Research #ERCStG! In the #METABAC project, we will explore how gut #bacteria contribute to #colorectal #cancer #metastasis formation. (1/12)

[George Cresswell @gcresswell]

1. Delighted to present work from my time in @AndreaSottoriva's lab, now in @NatureCancer! A big effort also led by @javierfermat and Nick Trahearn.

We combined genomics + digital pathology to measure evolution in a prostate cancer (PCa) clinical trial.

https://t.co/JWoBpIILN9

[Hamzeh Kay @hamkay02]

How do mismatch repair-deficient (MMRd) cancers trade off the evolutionary costs and benefits of elevated mutation rates?

Delighted to share our paper on adaptive mutability in MMRd colorectal cancer (CRC) @NatureGenet

https://t.co/BxUtYR1JEm

Tweetorial 🧵below

[Hugo Snippert @Snippertlab]

Very much love this story to demonstrate that adaptability during tumor evolution can also be achieved at the DNA level by reversible DNA mutations 🔥
@jansen_marnix @UMCU_CMM @oncodeinstitute

[Marnix Jansen @jansen_marnix]

Hypermutator cancers are defined by increased mutation rates.

But do mutation rates evolve with time during tumour growth?⏱️

In this work @NatureGenet we show that hypermutator cancers use an unexpected set of genetic gear switches to adapt mutation rates to immune selection.

[Hugo Snippert @Snippertlab]

Looking forward to present tomorrow morning at #FEBS2024. I’ll discuss our work on real-time single-cell signaling activities in #organoids, drug response and our latest push to advance the technologies involved @UMCU_CMM @oncodeinstitute

[Hugo Snippert @Snippertlab]

Very much enjoyed that we could contribute to the latest discovery of the Brummelkamp team

[MVermeulenLab @LabVermeulen]

Check our our latest publication on mouse and human gastruloids in Cell Stem Cell, spearheaded by @Suz_Stelloo with help from @MayteAlVin and many others in our lab and in collaboration with labs of Boudewijn Burgering, Harm Jan Vos, Maarten Altelaar and @SonnenKatharina

[OrganoidNL @OrganoidNL]

The 2nd edition of OrganoidNL was a great success! We are already looking forward to next year... stay tuned!

[OrganoidNL @OrganoidNL]

We are now live! Register for the 2nd OrganoidNL meeting @_amolf on April 12 🗓️.
Exciting talks with opening @HansClevers, keynote Margherita Turco, and talks from @JeroenPasterk @ColindaScheele, Rob Coppes and Quiwei Pan.
https://t.co/5nLrPYrIEM

[Hugo Snippert @Snippertlab]

@christophertape @CellCellPress This is amazing work Chris. Congratulations to you and your team. Looking forward to study the details

[Hugo Snippert @Snippertlab]

Extremely honoured to receive the ERC Consolidator this year #ERCCoG. Looking forward to the next 5 years of exciting science to unravel the intricacies how tumors become malignant. #CancerPrevention @UMCU_CMM @oncodeinstitute

[Oncode Institute @oncodeinstitute]

We are proud to announce that Oncode Investigators @rschneiderlab (@ErasmusMC), @jeroen_deridder & @Snippertlab (both @UMCUtrecht) will receive the @ERC_Research Consolidator Grant! Read more:
https://t.co/XgJcfkoEel

[Cassio Fleming @cassio_fleming]

Our lastest study "Targeted Perturbation of Signaling-Driven Condensates" is now live on Molecular Cell. We've used small peptides to specificaly disrupt β-catenin condensates, resulting in decreased transcription and inhibition of cancer cell proliferation. 🔬💡 📖 Read more:

[Andrea Sottoriva @AndreaSottoriva]

Is #cancer drug resistance heritable or plastic? Genetic or non-genetic? How do we tell those apart? We just begun measuring the temporal dynamics of evolving cancers using controllable patient-derived #organoids. We need more experiments+theory! https://t.co/UpsVHe8m7d

[Hugo Snippert @Snippertlab]

Walking on my way to EMBL cancer genome conference #EMBLCanGen

Excited to present our newest work on early-stage colon cancer later today

[EMBL Events @EMBLEvents]

Are you looking to keep up to date with the rapidly progressing area of cancer genomics? 🤔 Then join us for #EMBLCanGen! ➡️ https://t.co/cGiEtDEXk2
Submit your abstract by 23 Aug to be a part of this interdisciplinary community of cancer researchers 🥼

#cancerresearch #cancergenomics #molecularmedicine #systemsbiology

[Hugo Snippert @Snippertlab]

We welcome Sjors Middelkamp as our newest postdoc. He got off to a great start this week, being immediately awarded the NWO talent grant ‘Veni’ to continue his research on single-cell genome sequencing that he developed in the @BoxtelLab.
@UMCU_CMM @NWOFunding @oncodeinstitute

[NWO Funding @NWOFunding]

NWO has awarded Veni funding of up to EUR 280,000 to 188 promising researchers from the full breadth of science. This will allow the laureates to further develop their own research ideas over the next three years.
https://t.co/tUCSbytmva

[Edwin Cuppen @ecuppen]

Very proud to see our work on the pan-cancer comparison of the genomic landscapes of primary and metastatic tumor published in this weeks issue of Nature: https://t.co/oLm0fNHfFf. @fran_mj88 @arne_van_hoeck @HartwigMedical @UMCU_CMM @oncodeinstitute @VHIO

[Prisca Liberali @priscaliberali]

I am super happy to share the first work of the lab on #gastruloids. All started with @MariettaLHartl that was extremely brave to start a new project on early development. https://t.co/t8eZU5IxgE With @SimonSuppinger they showed mechanisms of gastruloid development