Gregory Macaluso

Heart Failure and Cardiac Transplant MD, Dad, and Notre Dame lover ‘00. tweets are my own

[Ahmed Bennis MD 🫀 @drbennisahmed]

💊🫀 What does optimal therapy actually buy a 65-year-old with HFmrEF/HFpEF?
From Nature Medicine (Vaduganathan et al., 2025):
🔴 SGLT2i + nsMRA → +3.6 years event-free survival
🔴 SGLT2i + nsMRA + ARNI → +4.9 years (LVEF <60%)
vs. standard therapy alone.
Nearly 5 extra years without hospitalization or death.
💡 These drugs exist. They work. Are all eligible patients receiving them?
Vaduganathan et al. Nature Medicine, Oct 2025
@mvaduganathan

#HeartFailure #HFpEF #HFmrEF #SGLT2i #ARNI #Cardiology #MedTwitter #NatureMedicine

[Anthony DiGiorgio, DO, MHA @DrDiGiorgio]

In other news, the sky is blue.

[Wesley Pritchett @wpritchett34]

This is Pure Gold. I had the pleasure of spending time with Coach Holtz. I wanted to hear him explain his Three Rules for Life! 1) Do what’s right - trust. 2) Do everything to the best of your ability- commitment. 3) Show people you care - love. It’s pretty simple. He goes on to highlight why the transfer portal is ruining college football. The kids are losing out on the life lessons learned- how to persevere, how to be committed to a program and a group of people. You miss out on the bonds you create over 4 years. If you leave, you still have the problem, you are changing the address. These are words to live by.

[Jerome Bettis @JeromeBettis36]

There are moments in life when words just aren’t enough. Losing Coach Holtz is one of those moments.

Coach was so much more than a football coach to me. He was family. I still remember the day he came to my house to recruit me. He didn’t just sit down and talk to me about football or what I could do on the field. He talked to me as a young man. And he spoke to my mom the way a man should speak to a mother who was trusting someone with her son. He looked her in the eye and promised that I would be taken care of at Notre Dame. That moment meant everything to us, and it’s something I’ve carried with me my entire life.

Coach Holtz believed in people. He believed in building men, not just players. He welcomed my entire family into the Notre Dame family and always made sure we felt that love and support. That’s who he was. He cared deeply about the people around him, and he made every one of us feel like we mattered.

The lessons he taught me went far beyond football. His faith, his discipline, his belief in doing things the right way shaped who I became as a man, a father, and a leader.

My heart is broken today, but I’m also filled with gratitude for the time I had with him and for the impact he had on my life. Coach will always be with us—in the lessons he taught, in the lives he changed, and in the love he gave so freely.

Thank you for everything, Coach. I love you.

You will forever be in our hearts.

Go Irish ☘️

[Notre Dame Football @NDFootball]

Head Coach Marcus Freeman’s statement on the passing of Lou Holtz

[Notre Dame Football @NDFootball]

Remembering the life and legacy of Lou Holtz

[Notre Dame Football @NDFootball]

eXcellence from Notre Dame to the NFL ❎☘️

Good luck to Defensive Rookie of the Year Nominee Xavier Watts at the @NFL Honors tonight.

#GoIrish☘️ | #IrishInTheNFL☘️ | @AtlantaFalcons | @xavierwatts6

[Jarrett Payton @paytonsun]

Full circle moment at #SuperBowl . Asked @Seahawks #WPMOY nominee @_jlove20 what the award means as a #Chicago kid. He remembered me speaking to his 3rd grade football team &amp; how it shaped his giving back journey. Grateful, Julian. 🙏🏽

[SeminOLD School @SeminOLDschool]

…they are also the first, last, &amp; ONLY team in CFB history to “move up” in the rankings after losing by FIVE TOUCHDOWNS &amp; failing to score a single TD of their own.

Weird huh?!

[Gregory Macaluso @gmac78]

🐻⬇️
Thanks for having me @ABC7Chicago @ChicagoBears

Cardiologist weighs in on 'Cardiac Bears https://t.co/0ZRzru7Y8k

[Nick shirley @nickshirleyy]

🚨 Here is the full 42 minutes of my crew and I exposing Minnesota fraud, this might be my most important work yet. We uncovered over $110,000,000 in ONE day. Like it and share it around like wildfire! Its time to hold these corrupt politicians and fraudsters accountable

We ALL work way too hard and pay too much in taxes for this to be happening, the fraud must be stopped.

[J5 Sports @J5_Sports1]

Sweetheart deal = getting into a 12 or 14 team playoff if you’re ranked inside the top 12 or 14?

These people cannot seriously be this stupid.

What is actually a sweetheart deal:
1. G5 teams getting autobids for winning conference championships while being ranked outside the top 20
2. SEC and Big 10 teams getting to play conference championship games with ZERO downside if you lose but a huge boost in seeding or an automatic playoff berth if you win
3. ACC/Big 12 teams getting a free shot at sneaking into the playoffs every year by just making the conference championship even if they are not top 12 teams (e.g., Clemson/ASU last year or BYU/UVA if they’d won this year).

Notre Dame’s “sweetheart” deal was put in place to guarantee them an at-large bid even if a more conference autobid oriented playoff structure was decided on and is totally reasonable.

[𝘽𝙪𝙘𝙠𝙚𝙮𝙚 𝙉𝙖𝙩𝙞𝙤𝙣 🌰 @Buckeye_Nation]

“The betrayal at Michigan has been institutional, systemic and years in the making. What those players are feeling now is simply the bill coming due for a university that decided winning mattered more than integrity, transparency or basic accountability.”

[The Torg @TorgRadio]

Please rt this. Let the world know what we know https://t.co/3PIJExv7Nv

[Pete Sampson @PeteSampson_]

Jeremiyah Love declares for the NFL Draft. RB1.

[Justin Spiro @DarkoStateNews]

Normally, I feel bad for the kids in these situations.

But at some point, isn’t it on the kids to choose a different school in the first place?

Can we honestly say they were blindsided by a UM scandal?

The program has a new scandal every 2 weeks. There have been so many, nobody even talks about them fighting 4 different schools in their tunnel and inciting 2 postgame brawls at the 50 in a 2-year span, then placing 100% of the blame on the other schools in all 6 incidents.

And is a UM coach getting arrested really unforeseeable?

Sherrone Moore was the 7th UM football staffer arrested since 2015.

And an 8th was busted in a pedophile sting.

8 criminal incidents in a decade?

By sheer statistics, these kids should be thrilled when they beat the odds and go a full year without a coach in handcuffs.

I’m not sure why they feel “betrayed”. They’re getting the exact sideshow they signed up for.

[Intrinsic @intrinsicvalyou]

Blake Corum’s name appears on #BC2LLC alongside his ex-roommate Connor O’Dea

O’Dea wouldn’t comment on Blake’s role
But per @nytimes, O’Dea admitted working with Stalions buying/selling refurbished goods

That leaves 2 possibilities: forged document—or ineligible player 〽️

[Justin Spiro @DarkoStateNews]

It’s impossible to get around.

In 2020, Michigan Football was getting blown out weekly.

They had nothing to play for, and stopped enforcing their own COVID protocols.

An outbreak occurred (most were asymptomatic or had mild symptoms), and the UM Athletic Department bailed on the season.

In 2021, Michigan Hockey had their own outbreak.

This time, the UM Athletic Department manipulated medical records and pressured UM Hockey players to lie about COVID-positive test results.

Why the change?

The hockey team was a 2-seed in the NCAA tournament, eyeing a national title.

The football team was 2-4, and had just gotten rolled at home by 0-5 Penn State.

When a title was up for grabs, Michigan falsified medical records to ensure games were played.

When they stunk and a Buckeye blood bath loomed, the same exact medical scenario presented far too dangerous a risk for them to take the field.

The same AD made both of these completely contradictory decisions just 3 months apart.

#GoBlue 〽️

[Awful Announcing @awfulannouncing]

Brady Quinn said the CFP is "controlled by ESPN and Disney," arguing the setup creates perceptions of bias toward the SEC.

https://t.co/3GvNASKmd7

[Mike Farrell @mfarrellsports]

Oldie but goodie

The Insufferable Myth of the ‘Michigan Man’ https://t.co/Cp0wHdL2WM