Optimized Biomimetic Syntheses of Discorhabdin B and Aleutianamine Drives a Deeper Exploration of Their Anticancer Potential | Journal of the American Chemical Society https://t.co/mchky0MJlM
3D degraders, enabled by redox-neutral radical cross-coupling, appearing today in @ChemRxiv : https://t.co/f5rrV2VOmg. A fabulous collaboration with BMS and the Parker lab.
TEN STEPS TO A MARINE TREASURE: Gram-Scale Synthesis of Bipinnatin J – featuring methods that weren't known ≅3 years ago to forge 3 key C–C bonds... Appearing today in @ChemRxiv (https://t.co/AVocmrW1zJ).
Quick Summary: A concise, scalable total synthesis of (–)-Bipinnatin J is disclosed. Commencing from inexpensive starting materials, this marine diterpenoid was fashioned through a highly convergent synthesis enabled by two Ni-electrocatalytic decarboxylative cross–couplings (DCC) leveraging succinate as an ethylene 2-carbon bridge, a unique halogen dance- Zweifel sequence to rapidly access a trisubstituted furan, a recently disclosed Ni-catalyzed 1,6-conjugate addition, and an asymmetric proton transfer.
Shout out to the team that made it happen: @tonyjohn07@griffin__barnes@maithiliterpene
Hydrogen-Atom-Transfer-Initiated Radical/Polar Crossover Annulation Cascade for Expedient Access to Complex Tetralins (Christopher D. Vanderwal and co-workers) @thevanderwallab @_lkjohnso #openaccess https://t.co/bpEexGfEOB
In 2016:
70% of 18-29-year-olds DID NOT vote
60% of 30-44-year-olds DID NOT vote
Only 38% of 45-64-year-olds did not vote & just 15% of 65+ did not vote
There is a reason America isn't progressing. It’s because the people who care about progress don’t care about voting
VOTE!!