Research team at Heidelberg University (Germany) focusing on next-gen AAV & bocavirus vectors for human gene therapy #AAV#genetherapy#biotech#biotechnology
Hats off to the Oliver Mรผller lab for their RNA-based directed evolution of novel AAV9 capsid variants for potent species-independent gene transfer to cardiomyocytes of mouse, rat or human origin ๐โค๏ธโ๐ฉน Thx for the great collaboration & joint publication: https://t.co/MIGBV5rTBT ๐ค
Glad that our lab could contribute to 2 AAV papers that have now won the "Paper of the Quarter" award by the German Society of Gene Therapy (@DGGTeV) https://t.co/Br0tyw5owS Congrats to Jannik Wagner (Klaus รberla lab) & Burak Demircan / Luca Zinser (Christian Buchholz lab) ๐ฅ๐
Honored to be a co-author w/ amazing colleagues from Universities Vienna, Stanford, Tรผbingen & Karolinska Institute on a review on cochlear gene therapy: https://t.co/bgmdNS39I7 Thx & congrats Lukas, Ellen, Francois, Steffen & Chris ๐ฆป๐ค @CederrothCR@uni_tue@UniHeidelberg#AAV
Congrats to our 2 brilliant students - Anna Schneider & Lea Heckelmann - who graduated w/ a BSc in Biosciences & w/ top grades (1.0) ๐ฅ๐ Fantastic work on new bocaviral vectors for human gene therapy (Anna) or optimized AAV vectors for antibody expression (Lea) ๐ @UniHeidelberg
Happy to see a "Research highlight" article written by our PhD student Jixin Liu published in Signal Transduction and Targeted Therapy: https://t.co/EIS7RH1wYi Well done, Jixin, and congratulations ๐๐ !
THX to all PhD students & speakers who made our "HBIGS Summer school 2024" on gene therapy such a success & so much fun ๐คโ๏ธ๐จ๐ณ๏ธ๐ณ ! Thx to @HBIGS_HD for funding & @RevvityLifeSci for extra support! Thx @DominikNiopek & Martina Weiss for the co-organization ๐๐ซ #genetherapy#AAV
Had a fantastic time at the XIX Parvovirus Workshop in Leuven (Belgium). Thx to Els Henckaerts & her local team - you did great ๐๐ Congrats to our PhD student Yumi Sano whose exciting work on new Bocavirus vectors attracted a lot of attention. More here: https://t.co/lguD24r3CE
The European Rare Diseases Research Alliance @ERDERA_org kicks off with a bold vision to make Europe a global leader in rare diseases research and innovation. ๐
Read press release๐๏ธhttps://t.co/8hvRh9CNQEโ
๐๐ #ERDERA#RareDiseases@EUScienceInnov@HorizonEU@Inserm
Happy, humbled & honored that our lab is a partner in the new & comprehensive "European Rare Diseases Research Alliance - ERDERA" that unites >170 organizations from 37 countries in our joint ambition to deliver tangible solutions to rare diseases patients around the world ๐คฒ๐ค๐ซ
We are now ERDERA! This new partnership builds on EJPRD achivements to continue advancing diagnosis, prevention, and treatment research for the 30+ million people living with a rare disease in Europe and beyond. ๐ https://t.co/bNag1Bd8N2
Excited that our collab w/ Wibke Bayer (@BayerWibke) & Matthias Vorgerd on a screen of antibodies against 18 AAV variants is published: https://t.co/1MQl1hJa9j Congrats to co-authors Ellen Wiedtke, Yumi Sano, Nico Fischer & Lisa Schiller (former) from our lab & all others ๐ค #AAV
Had an absolute blast with the whole lab playing Urban golf in a beautiful sunny area near Heidelberg, followed by aprรจs-golf lunch at Neuburg monastery. My heartfelt thanks to each & everyone of you for making this such a fun day & a fantastic team event to remember ๐โ๏ธ๐ซ๐๐๐ป
Thrilled that our work with Christian Buchholz (@PEI_Germany) & Petr Chlanda (@ChlandaL) on DARPin-modified AAVs for selective ex/in vivo targeting to CD8+ T-cells is now out in Molecular Therapy: https://t.co/MOc6WoyZft Congrats to 1st author Burak & all co-authors ๐๐ #AAV
Thank you very much to Richard Horgan (@RichHorgan, 2nd from the right) & Ahna Gavrelos (right) from "Cure Rare Disease" (CRD, @CureRareDisease) for their visit to our lab, a great talk by Rich at our institute & a fun dinner in the old city ๐ฅ๏ฟฝ๏ฟฝ๐ฅจ๐ป Please support CRD ๐ช ! #AAV
Happy that our joint article with Ulrike Protzer's lab (@ProtzerLab) on the use of AAV vectors for development of HBV mouse models is now out: https://t.co/wgBcPOtos4 Congrats to 1st author Lisa Schiller, our former MSc student & now PhD student in the Protzer lab ๐๐ฅ #AAV#HBV
Very excited and honored to announce that I have been selected as a Young Marsilius Fellow for Interdisciplinary Research and Science Communication for the 2024/2025 academic term. Looking forward to meeting great scholars and doing lots of brainstorming for science communication
The 2nd in Communications Biology is from our collab with Klaus รberla's lab (@KUberla) incl 1st author Jannik Wagner & our partners at Sirion/Revvity incl Christian Thirion (@RevvityLifeSci@sirionbiotechmu): https://t.co/JKQhcCRpJR Congrats & thank you to all co-authors ๐๐๐ฅ
Excited about 2 new papers illustrating the potential of our myotropic AAVMYO vector for preclinical evaluation of muscle-directed interventions. The 1st in Nature is from a collab w/ Jeff Chamberlain's lab incl 1st author Hichem Tasfaout (@TasfaoutH): https://t.co/sAuDWpz2WB
Existing #Cas12a nucleases are too large for #AAV-based #GeneTherapy. @grimmlab explores a #PLOSBiology study of a new Cas12a variant, compatible with in vivo #GenomeEditing via all-in-one AAV delivery. Paper: https://t.co/CZQCZ54cFo Primer: https://t.co/AuADVk8CB9
Congrats to Marco Thรผrkauf (1st author), Randall Platt (@randall_platt), Markus Ruegg (@RueggLab) and all co-authors that this paper, which showcases the potential of our AAVMYO vector for in vivo gene knockouts, is now out in Nature Communications: (https://t.co/Dv3AJv9C5N) #AAV
Thank you very much, too, Markus, Marco & Randall, for the unique opportunity to collaborate and to support your exciting & original project with our muscle-tropic AAV vector ๐ ! Fingers crossed for the full submission ๐ค๐ !! @RueggLab@randall_platt#AAV#GeneTherapy#Vector