New paper in @Bone_Research Inflammation doesn't just stop bone formation—it changes osteoblast identity.
NF-κB turns OBs into catabolic "aiOCy-L cells" via IKK2→mTOR→glycolysis. Blocking it rescues them. Implications for RA & OA. @abuamer_lab
https://t.co/qvKjOOJ5w7
A drug used to treat anemia might hold the key to better nerve healing. U of A researchers found that erythropoietin speeds up recovery from nerve crush injuries in mice by helping cells clean up damage and rebuild protective coverings. More: https://t.co/W8LufY8BeH
Looking forward to this Friday's Avioli Musculoskeletal Research Seminar:
“A Runted tale about skeletal homeostasis and repair”
Info: https://t.co/waL8HTVTAO
@WashU_BMD,@WUSTLdbbs,@washu_ortho_res,@WashUBME,@dveislab
This study identified the transcription factor IkBzeta (IĸBζ) as key regulator of inflammation in the synovial joint. Genetic and pharmacologic approaches showed that blocking IĸBζ diminishes inflammatory arthritis in mice.
In A&R
https://t.co/w1jb5TS2Ux
@abuamer_lab
IĸBζ is a central modulator of inflammatory arthritis pathogenesis - Swarnkar - Arthritis & Rheumatology - Wiley Online Library https://t.co/JpdW5fkYBH
@abuamer_lab@WashU_MRC@washu_ortho_res
Register today for our next Reviewer Training Track webinar next Monday, July 29 at 11 AM EDT! Join @dveislab as she discusses communication with editors and providing constructive feedback to authors.
Registration open to all ASBMR members: https://t.co/OsijKKvp1b
Looking forward to this Friday's Avioli Musculoskeletal Research Seminar:
"FGF Signaling and Skeletal Development."
Info: https://t.co/waL8HTVlLg
@WashU_BMD,@WUSTLdbbs,@washu_ortho_res,@WashUBME,@dveislab
Excited to share our recent preclinical study published in @PNASNews, demonstrating a potential therapeutic modality for arthritis.
DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8 | PNAS https://t.co/XyruAy20g7
20-30% of scientists may be using commercial antibodies that don’t work as advertised in their protein studies, potentially skewing results. https://t.co/z0DvGseExY.
Looking forward to this Friday's Avioli Musculoskeletal Research Seminar!
Info: https://t.co/waL8HTVTAO
@WashU_BMD,@WUSTLdbbs,@washu_ortho_res,@WashUBME,@dveislab