guido lenz

[Oscar Tahuahua @OscarTahuahua]

🧵
If you still think of cancer as a list of mutations, you’re missing the bigger picture.

In @CellCellPress, Douglas Hanahan redefines the Hallmarks of Cancer.
This is not an update, it’s a new way of thinking about cancer.

Here are the 7 most relevant changes 👇 @OncoAlert

[Oscar Tahuahua @OscarTahuahua]

More evidence that #immunotherapy works better in the morning.

In a prospective, randomized phase III trial, giving first-line chemo-immunotherapy earlier in the day (<15:00) nearly doubled PFS (11.3 vs 5.7 mo, HR 0.40) and improved OS (28.0 vs 16.8 mo; HR 0.42) in advanced NSCLC.

More effective, no added cost and easy to implement.
Likely reflects circadian immune rhythms with greater CD8⁺ activation and less T-cell exhaustion.
https://t.co/q4JrFU4yws @OncoAlert

[Johannes Gräff @GraeffJohannes]

And it’s the cover!!

[Christoph Bock Lab @ CeMM & MedUni Vienna @BockLab]

🗨️ Just published in @NatureBiotech: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells &amp; figure out the biology without writing any computer code. Paper link and annotated walkthrough in the thread below (1/11)

[Nicholas Fabiano, MD @NTFabiano]

These findings are from a systematic review in Ageing Research Reviews which examined the dose-response relationship between overall and specific types of exercise with cognitive function in older adults. https://t.co/NEDtn5idt9 2/10

[Razvan Borza @rborza_]

🚨 Great alternatives to BioRender are now available!!

📢 @NIAIDNews offers a collection of public figures and icons for everyone to use. Check it out at https://t.co/cZFQAf5nTz

[Maxim Greenberg @maxvcg]

Nobel Prize in Physiology or Medicine: Biology
Nobel Prize in Chemistry: Biology
Nobel Prize in Physics: Sounds like Biology

#NobelPrize

[guido lenz @gulenz]

The new world of AI taken over the Nobel

[David Adams @David_J_Adams]

Thanks to @gulenz for visiting us @sangerinstitute this week.

[guido lenz @gulenz]

@David_J_Adams @sangerinstitute Thank you for hosting me. Really great.

[Alexandre Bruni-Cardoso @AleBruniCardoso]

Excelent work! I tried Ultrack in a few time lapses and it worked really well without much adjusting. Also, the segmentation workflow is amazing. I have been using it not only for videos

[guido lenz @gulenz]

@ItaiYanai Great insights - the phenome space is always larger than the genome space, indicated by the fractionate killings of clonal cells. 10.1158/0008-5472.CAN-21-1940

[Itai Yanai @ItaiYanai]

Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️
https://t.co/Jgx79K3i3a @Gustavo_SFranca

[eriksahailab @eriksahailab]

Very pleased to share our latest preprint on MAPK dynamics and cell fate decisions in lung cancer https://t.co/nGnBprWi8m . Does EGFR mutation mean MAPK is always on? NO, it shows dramatic pulses👇1/4

[guido lenz @gulenz]

@AnnabelQuinet @JahjahTiya @jennysingh91 @PoloSophie @GAVETLab @SarahLa47195747 @TeamChenCurie @Pages_Lab Congrats Annabel

[guido lenz @gulenz]

In this review I propose the concept of hetness, which is the capacity of generating heterogeneity during development but also in tumorigenesis. Check it out - https://t.co/wfgrl3NxSP

[guido lenz @gulenz]

@_stragliotto @metsul Porque ainda tem um diferença do Guaíba e de Porto Alegre por causa das contenções. Se equilibrar os dois lados pode subir muito mais.

[guido lenz @gulenz]

@ProfDenisePires A explicacao provavelmente está ligada à selecao antural. Imagino que a informação que tem uma manada de leões por perto afeta mais o fitness do que saber que tem uma árvore de fruta por perto. Sem a fruta possivelmente aquele ser sobreviveu, com os leões, não.

[guido lenz @gulenz]

@AJKowaltowski Loved the "Novel sensors for unveiling the dynamic subcellular redox landscape" - depois tu me diz se são sensors genéticos

[guido lenz @gulenz]

@oliveirajhm acho que tem uma proporção saudável de artigo de pesquisa e revisão - obviamente precisa de bem mais artigos de pesquisa do que revisão, mas ter artigos de revisão, principalmente quando eles propõe uma visão integrada e inovadora da área, é um sinal de maturidade científica