Sifeng Gu, PhD

Ph.D. from @Komorlab | UCSD Chemistry & Biochemistry | Genome Editing

[Nature Biotechnology @NatureBiotech]

Precise, minimally evolved adenine base editors generated through mutation reversion analysis https://t.co/cWSs7Q8srF

[Armand @armandcognetta]

There’s an enormous gap in the longevity field that almost no one is talking about.

No existing therapeutic modalities are capable of both systemic distribution and complex transformations.

Until we solve this, we won’t solve aging. 🧵

[Sifeng Gu, PhD @GuSifeng]

🚀 So excited to share that our manuscript on Multiplexed Orthogonal Base Editor (MOBE) systems is now online! Honored to have helped Quinn @Quinn_Cowan_sci on this amazing project, which combines the best of ABE and CBE. It was a truly fun and rewarding journey!

[Quinn Cowan, PhD @Quinn_Cowan_sci]

Excited my PhD work is out now @NatureBiotech!

We report Multiplexed Orthogonal Base Editor (MOBE) systems: tools to simultaneously install distinct point mutations. MOBEs introduce co-occurring genetic variants (polygenic disease, haplotypes)🧬

🧵⬇️ 1/ https://t.co/6flqNaZdLW

[Sifeng Gu, PhD @GuSifeng]

@annikalikeschem Thanks! You also did great work in this project! So congrats on you too😏

[Sifeng Gu, PhD @GuSifeng]

Really enjoyed #deaminet2023 ! Great to hang out with the lab and many outstanding scientists during the conference! Please stay tuned for more upcoming work on base editing mechanisms.

[Komor Lab @KomorLab]

Greetings from Palm Springs! The whole lab had a great time at #deaminet2023. Wonderful to hear about all the amazing science being done in the field of #baseediting. Special shout out to @GuSifeng who crushed his talk yesterday!

[Komor Lab @KomorLab]

We had a wonderful time mentoring our #ENLACE high school students Isabel and Angie over these past 7 weeks. All the best in your senior year!

[Komor Lab @KomorLab]

We are excited to share Double Tap with you all in @NatureComms! In collaboration with @ValentinoGantz, we show that HDR can be improved using secondary gRNAs that target indel byproducts. Congrats to @Zsolt_Bodai and @bishop_alena!
https://t.co/sNxEowWAwL
https://t.co/heYpZ0WnmQ

[Komor Lab @KomorLab]

Congrats to our amazing postdoc @Zsolt_Bodai who had been named a #CottrellFellow! This award will support Zsolt as he continues his research to uncover the mechanisms by which base editors work and gains undergraduate teaching experience. https://t.co/XEvK7wsjXE

[Sifeng Gu, PhD @GuSifeng]

We first review deoxyuridine, deoxyinosine, and single-stranded break repair. Then, we discuss how interactions among these different repair processes can lead to different base editing outcomes. Hope this would be helpful and feel free to exchange any thoughts with us! 2/2

[Sifeng Gu, PhD @GuSifeng]

Super stoked that this review got published. It was a really fun journey writing this with @Zsolt_Bodai, @Quinn_Cowan_Sci and our boss Alexis @KomorLab. To our knowledge, this is the first review paper that focuses on discussing DNA repair mechanisms involved in base editing! 1/2

[Komor Lab @KomorLab]

Check out our new review by @GuSifeng @Zsolt_Bodai and @Quinn_Cowan_Sci that discusses the potential DNA repair mechanisms that process base editor intermediates! https://t.co/Gfe93iC6R2

[Sifeng Gu, PhD @GuSifeng]

Proud to be part of this! Say no to racism, prejudice and inequality.

[Komor Lab @KomorLab]

In observance of of #ShutDownSTEM we have drafted a Statement of Support for the #BLM movement with a list of actions we will take to combat racism and enforce equity and diversity in our community #BlackLivesMatter #ShutDownAcademia @UCSDChemBiochem @AcademicChatter @UCSDPhySci

[Sifeng Gu, PhD @GuSifeng]

@KomorLab Thanks all of my excellent lab mates for the support !

[Komor Lab @KomorLab]

Congratulations to @GuSifeng, the first PhD candidate in the lab! Great job on your 3rd Year Exam!!!

[Dr./Prof. Keolu Fox @KeoluFox]

Happy to publish with my Indigenous Brothers & Sisters (again). Mandatory quarantine reading for anyone working in genomics, information policy, or #datascience @UNGlobalPulse @ResearchUCSD @ObamaFoundation 💻🧬

[Sifeng Gu, PhD @GuSifeng]

Big shout out for Dr Zhong and my undergrad institute the University of Edinburgh!

[Komor Lab @KomorLab]

Lab happy hour to celebrate @CA_Vasq receiving a #FordFellowship! Awesome news in an otherwise not-so-awesome time. #DiversityInSTEM

[Komor Lab @KomorLab]

Congratulations to @Quinn_Cowan_Sci (pictured here with his remote exam setup) for passing his 2nd Year Departmental Exam!!! 🥳 #StaySafeStayHome #RemoteScience

[Komor Lab @KomorLab]

A big thank you to @NHMLA for inviting Alexis and the Komor Lab to #FirstFridays where Alexis discussed the future of medicine alongside @Blazing_Science and pulitzer prize writer @pattmlatimes. Until next time! #thefutureisnow @UCSDPhySci

[Komor Lab @KomorLab]

A big congratulations and happy early birthday to @CA_Vasq for passing his 2nd Year Departmental Exam!!!

[Sifeng Gu, PhD @GuSifeng]

Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19 - The Lancet https://t.co/6gW1791fuz