😊🙏🏻 Happy to share our newly published article in 📢💊
"Protocol-constrained AI enhances tacrolimus dosing accuracy in kidney transplant care"
🔗 Read the full open-access article here: https://t.co/7aEbhONNKB
Tacrolimus dosing after a kidney transplant is highly complex, individualized, and prone to variability. To help address this, our team developed TacroDose AI—a protocol-constrained large language model (LLM) designed to generate dosing recommendations that strictly align with established institutional guidelines.
💡 Key Findings:
🔹 After refining our model with structured output verification (TacroAI 2.0), we achieved a remarkable 91.7% protocol adherence.
🔹 Crucially, we reduced sentinel errors to just 1.0% and significantly improved reproducibility.
🔹 This provides a powerful framework for integrating generative AI with rule-based clinical protocols to support safe, clinician-supervised medication management in transplant care.
A huge congratulations to my outstanding mentee and first author, Benjamin Bizer, and our fantastic fellows who drove this project! 👏✨ I am so incredibly grateful to collaborate with this brilliant team: Oscar A Garcia Valencia, Flora Kincses, Jose Arriola-Montenegro, Charat Thongprayoon, and Jing Miao, Wisit Cheungpasitporn. @josearriolam@OscarGarciaMD@jingmiao2019@MayoClinicNeph@FrontiersIn
Wisit Cheungpasitporn, MD, FACP, FASN, FAST
Clinician-Scientist & Professor of Medicine, Mayo Clinic
Leading AI Innovation in Kidney Care
#KidneyTransplant #Nephrology #ArtificialIntelligence #GenerativeAI #Tacrolimus #DigitalHealth #ClinicalDecisionSupport #MedicalEducation #HealthcareAI #FutureOfMedicine #MayoClinic
In this article I argue against using clinical remission as an endpoint for stopping IS therapy in lupus nephritis! There is a pro position, as well as moderator commentary. Hope you enjoy it! @asnpublications
https://t.co/zl4Q1ZkvCj
😃✨ Last Day of the KDIGO Controversies Conference on Technological Advancements to Support Guideline-Informed Care (20–23 November 2025, Madrid 🇪🇸) @goKDIGO
Today was an inspiring final day as we presented the refined summaries, integrated feedback across all eight questions, and continued shaping a cohesive synthesis for the conference report. We also engaged in focused discussions to map out the key research gaps and research priorities that will guide future work in technology-enabled, guideline-informed kidney care. 💡
🙏 We are grateful for the opportunity to collaborate with such an exceptional group of global colleagues whose insights and dedication continue to push the field forward. @FrancescoPesce
🤝 Looking ahead, we are excited for the continued partnerships, shared learning, and innovative projects that will emerge from this week.
@MayoClinicNeph
Conference link 🔗
https://t.co/b3uuO1AWNY
Dr Eltenemy presenting on his series is k and spk robotic transplants. With 3 d surgical planning, lab experience and practice comprable ischemia time. @DonateLifeEG
👏 So proud to see our Mayo Clinic Nephrology fellows deliver outstanding oral and poster presentations at American Society of Nephrology #KidneyWk 2025 — showcasing excellence, innovation, and collaboration.
🙏🏻 Thanks 😊 @ASNKidney@Arjun_Mohan1@h4amer@k1dneyMD@wisit661
Excited to share our recently published case report on RAS. Highlighting the potential role of revascularization in select high-risk cases 🫘 👏🏽
Thanks for the opportunity and guidance @SamyRiad9@MayoClinicNeph
https://t.co/0O3wr0TAUX
Dr Sas discussing with Dr Adrogue outcomes of a novel therapy for Primary hyperoxaluria that can avoid the need for transplant. @MayoClinicNeph @AdrogueHoracio