Top Tweets for #ACUTEPAIN
Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/3IDd9jdcm7 #stopthepain

Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/3IDd9jdcm7 #stopthepain

Explore the latest in acute pain management at this educational session on emerging therapies, clinical trial data and evidence-based treatment approaches.
๐
Oct. 20 | 9โ10 AM ET
Free to attend: https://t.co/FijwKakmAz
#AcutePain #PainManagement #MedicalEducation

Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/3IDd9jdcm7 #stopthepain

@jeffgadsden @amit_pawa @EMARIANOMD @DaraEsra @RegionalAnaesUK @CAREsraPortugal @Paul_Wischmeyer @OBsleepmerchant @maffygirl @anesthesiadocmd @Duke_Anesthesia @NavBahal @Steve_Coppens @NarouzeMD @ajrmacfarlane @galusweegie @nelkassabany @DrJeniMD @Nadia_Hdz_MD @PedsAnesNet Not trying to, just offering a systemic #OpioidSparing option that is particularly efficacious for #AcutePain abdominal Sx, especially when regional techniques are not available, contraindicated or failed etc. #IVLido
Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/3IDd9jdcm7 #stopthepain

โก ๐ฆ๐จ๐ญ๐๐ง๐ฅ๐๐๐๐ก๐: ๐ฆ๐๐๐๐๐ง๐๐ฉ๐ ๐๐๐๐ก๐ก๐๐ ๐๐๐ข๐๐๐๐๐ โ ๐ฆ๐๐๐๐๐ง๐๐ฉ๐ ๐ฃ๐๐๐ก ๐ง๐๐ฅ๐๐๐ง๐๐ก๐
#Suzetrigine #NaV18 #AcutePain #PainMedicine #RegionalAnaesthesia #RegionalAnesthesia #NonOpioidAnalgesia #PerioperativeMedicine #OpioidSparing #CriticalAppraisal
๐๐ฅ๐๐ง๐๐๐๐ ๐๐ฃ๐ฃ๐ฅ๐๐๐ฆ๐๐:
Suzetrigine is an exciting new addition to non-opioid analgesia.
Its pharmacology is attractive, but an important distinction remains: ๐บ๐ผ๐น๐ฒ๐ฐ๐๐น๐ฎ๐ฟ ๐๐ฒ๐น๐ฒ๐ฐ๐๐ถ๐๐ถ๐๐ is not the same as ๐ฎ๐ป๐ฎ๐๐ผ๐บ๐ถ๐ฐ๐ฎ๐น ๐๐ฒ๐น๐ฒ๐ฐ๐๐ถ๐๐ถ๐๐.
๐ ๐ฆ๐จ๐ญ๐๐ง๐ฅ๐๐๐๐ก๐ - ๐ช๐๐๐ง ๐๐ฆ ๐๐ง?
๐น ๐๐ฟ๐๐ด ๐ฐ๐น๐ฎ๐๐: Novel non-opioid analgesic
๐น ๐ฃ๐ฟ๐ถ๐บ๐ฎ๐ฟ๐ ๐๐ฎ๐ฟ๐ด๐ฒ๐: Voltage-gated sodium channel NaV1.8
๐น ๐ ๐ฒ๐ฐ๐ต๐ฎ๐ป๐ถ๐๐บ: Reduces excitability of peripheral nociceptive neurons
๐น ๐๐ฒ๐ ๐๐๐ฟ๐ฒ๐ป๐ด๐๐ต: High molecular selectivity for NaV1.8
๐น ๐๐ฒ๐ ๐น๐ถ๐บ๐ถ๐๐ฎ๐๐ถ๐ผ๐ป: Systemic administration provides no anatomical selectivity for the painful territory
๐ต ๐. ๐๐ก๐๐ง๐ข๐ ๐๐๐๐ ๐ง๐๐ฅ๐๐๐ง๐๐ก๐
๐น ๐ฃ๐ฎ๐ถ๐ป ๐ด๐ฒ๐ป๐ฒ๐ฟ๐ฎ๐๐ผ๐ฟ: Usually a defined injured, inflamed or surgical territory
๐น ๐๐ฑ๐ฒ๐ฎ๐น ๐๐ฎ๐ฟ๐ด๐ฒ๐: Nociceptive pathways arising from that specific region
๐น ๐ฅ๐ฒ๐ด๐ถ๐ผ๐ป๐ฎ๐น ๐ฎ๐ป๐ฎ๐ฒ๐๐๐ต๐ฒ๐๐ถ๐ฎ: Targets the relevant neural pathway directly
๐น ๐ฆ๐๐๐ฒ๐๐ฟ๐ถ๐ด๐ถ๐ป๐ฒ: Circulates systemically rather than selectively targeting only the painful territory
๐ต ๐. ๐ช๐๐๐ฅ๐ ๐๐ฆ ๐ก๐ฎ๐ฉ๐ญ.๐ด ๐ฃ๐ฅ๐๐ฆ๐๐ก๐ง?
๐น ๐ฃ๐ฟ๐ฒ๐ฑ๐ผ๐บ๐ถ๐ป๐ฎ๐ป๐ ๐น๐ผ๐ฐ๐ฎ๐๐ถ๐ผ๐ป: Peripheral nociceptive sensory neurons
๐น ๐ ๐ฎ๐ท๐ผ๐ฟ ๐๐ถ๐๐ฒ๐: Dorsal root ganglia and trigeminal ganglia
๐น ๐๐ถ๐๐๐ฟ๐ถ๐ฏ๐๐๐ถ๐ผ๐ป: NaV1.8-expressing neurons innervate tissues throughout the body
๐น ๐๐ฒ๐ ๐ฝ๐ผ๐ถ๐ป๐: NaV1.8 is relatively selective for nociceptive pathways, but it is ๐ป๐ผ๐ confined to the site of injury
๐ต ๐. ๐ ๐ข๐๐๐๐จ๐๐๐ฅ ๐๐ ๐๐ก๐๐ง๐ข๐ ๐๐๐๐ ๐ฆ๐๐๐๐๐ง๐๐ฉ๐๐ง๐ฌ
๐น ๐ฆ๐๐๐ฒ๐๐ฟ๐ถ๐ด๐ถ๐ป๐ฒ: Highly selective for NaV1.8
๐น ๐๐ผ๐ฐ๐ฎ๐น ๐ฎ๐ป๐ฎ๐ฒ๐๐๐ต๐ฒ๐๐ถ๐ฐ๐: Block multiple voltage-gated sodium-channel subtypes
๐น ๐ฆ๐๐๐ฒ๐๐ฟ๐ถ๐ด๐ถ๐ป๐ฒ ๐ฎ๐ฑ๐๐ฎ๐ป๐๐ฎ๐ด๐ฒ: Molecular precision
๐น ๐ฅ๐ฒ๐ด๐ถ๐ผ๐ป๐ฎ๐น ๐ฎ๐ป๐ฎ๐ฒ๐๐๐ต๐ฒ๐๐ถ๐ฎ ๐ฎ๐ฑ๐๐ฎ๐ป๐๐ฎ๐ด๐ฒ: Anatomical precision
๐ ๐ฆ๐ฒ๐น๐ฒ๐ฐ๐๐ถ๐๐ฒ ๐ฐ๐ต๐ฎ๐ป๐ป๐ฒ๐น ๐ฏ๐น๐ผ๐ฐ๐ธ๐ฎ๐ฑ๐ฒ โ ๐๐ฒ๐น๐ฒ๐ฐ๐๐ถ๐๐ฒ ๐ฝ๐ฎ๐ถ๐ป-๐๐ถ๐๐ฒ ๐๐ฎ๐ฟ๐ด๐ฒ๐๐ถ๐ป๐ด.
๐ต ๐. ๐ฆ๐จ๐ญ๐๐ง๐ฅ๐๐๐๐ก๐ ๐๐ ๐๐ข๐๐๐ ๐๐ก๐๐๐ฆ๐ง๐๐๐ง๐๐๐ฆ
๐น ๐๐ผ๐บ๐บ๐ผ๐ป ๐ฝ๐ฟ๐ถ๐ป๐ฐ๐ถ๐ฝ๐น๐ฒ: Both reduce nociceptive transmission through sodium-channel inhibition
๐น ๐๐ผ๐ฐ๐ฎ๐น ๐ฎ๐ป๐ฎ๐ฒ๐๐๐ต๐ฒ๐๐ถ๐ฐ: Anatomically targeted + molecularly broad
๐น ๐ฆ๐๐๐ฒ๐๐ฟ๐ถ๐ด๐ถ๐ป๐ฒ: Molecularly targeted + anatomically broad
๐น ๐๐ฒ๐ ๐ฑ๐ถ๐ณ๐ณ๐ฒ๐ฟ๐ฒ๐ป๐ฐ๐ฒ: Regional anaesthesia concentrates sodium-channel blockade within the neural pathway serving the injured territory
๐ต ๐. ๐ฆ๐จ๐ญ๐๐ง๐ฅ๐๐๐๐ก๐ ๐๐ ๐ข๐ฃ๐๐ข๐๐๐ฆ
๐น ๐ฆ๐๐๐ฒ๐๐ฟ๐ถ๐ด๐ถ๐ป๐ฒ: NaV1.8 inhibition
๐น ๐๐ผ๐ฐ๐ฎ๐น ๐ฎ๐ป๐ฎ๐ฒ๐๐๐ต๐ฒ๐๐ถ๐ฐ๐: Broader NaV blockade
๐น ๐ข๐ฝ๐ถ๐ผ๐ถ๐ฑ๐: Opioid-receptor-mediated pain modulation
๐น ๐ฃ๐ฒ๐ฟ๐๐ฝ๐ฒ๐ฐ๐๐ถ๐๐ฒ: Mechanistically, suzetrigine is closer to ๐๐ผ๐ฑ๐ถ๐๐บ-๐ฐ๐ต๐ฎ๐ป๐ป๐ฒ๐น ๐ฎ๐ป๐ฎ๐น๐ด๐ฒ๐๐ถ๐ฎ than to opioid pharmacology
๐ฏ ๐๐๐ฌ ๐ง๐๐๐๐๐ช๐๐ฌ๐ฆ
โ
๐ ๐ผ๐น๐ฒ๐ฐ๐๐น๐ฎ๐ฟ ๐๐ฒ๐น๐ฒ๐ฐ๐๐ถ๐๐ถ๐๐ โ ๐ฎ๐ป๐ฎ๐๐ผ๐บ๐ถ๐ฐ๐ฎ๐น ๐๐ฒ๐น๐ฒ๐ฐ๐๐ถ๐๐ถ๐๐
โ
NaV1.8 selectivity does not necessarily mean pain-site selectivity
โ
๐๐ผ๐ฐ๐ฎ๐น ๐ฎ๐ป๐ฎ๐ฒ๐๐๐ต๐ฒ๐๐ถ๐ฐ = anatomically selective, molecularly broad
โ
๐ฆ๐๐๐ฒ๐๐ฟ๐ถ๐ด๐ถ๐ป๐ฒ = molecularly selective, anatomically broad
โ
Opioids act through a fundamentally different receptor-based mechanism
โ
Suzetrigine may be a valuable component of multimodal analgesia, but it does not reproduce the anatomical precision of RA
๐ก ๐ง๐๐ ๐๐ข๐ฅ๐ ๐ค๐จ๐๐ฆ๐ง๐๐ข๐ก
๐ก๐ผ๐ ๐ผ๐ป๐น๐ โ๐ช๐๐๐๐ ๐ฐ๐ต๐ฎ๐ป๐ป๐ฒ๐น ๐ฑ๐ผ ๐๐ฒ ๐ฏ๐น๐ผ๐ฐ๐ธ?โ
๐๐๐ ๐ฎ๐น๐๐ผ โ๐ช๐๐๐ฅ๐ ๐ฑ๐ผ ๐๐ฒ ๐ฏ๐น๐ผ๐ฐ๐ธ ๐ถ๐?โ

Phase 3 trials evaluate #suzetrigine, a selective NaV1.8 inhibitor, for moderate-to-severe #acutepain.
๐ LSMD SPID48 vs. placebo:
โข Abdominoplasty: 48.4 (P < .0001)
โข Bunionectomy: 29.3 (P = .0002)
Read the review: https://t.co/Bh2tyiqyYf
#PainManagement #ClinicalTrials

Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/3IDd9jdcm7 #stopthepain

Guess who called me this evening and told me the swelling has gone down and the pain have already reduced very much. The way he was so proud of me eeh.
Have never been so proud of myself. ๐
#Physiotherapy
#prouddaughter
#acutepain
Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/3IDd9jdcm7 #stopthepain

Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/3IDd9jdcm7 #stopthepain

Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/IV7X0rQgzg #stopthepain

"I then realise that the entire #hospital ward had fallen into solemn silence [after my screaming]. Strangers would gaze at me from the corner of their downcast eyes; I had become the momentary emblem of their #mortality": https://t.co/vF2MF1pk8C
#ChronicPain #DVTs #AcutePain
![AChVoice's tweet photo. "I then realise that the entire #hospital ward had fallen into solemn silence [after my screaming]. Strangers would gaze at me from the corner of their downcast eyes; I had become the momentary emblem of their #mortality": https://t.co/vF2MF1pk8C
#ChronicPain #DVTs #AcutePain https://t.co/WseTpBg67T](https://pbs.twimg.com/media/HQMh_bZWkAAnTo-.jpg)
Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/3IDd9jdcm7 #stopthepain

A review of 59 systematic reviews covering 50+ acute pain conditions challenges assumptions about opioids. Researchers found small, short-term relief for many conditionsโand no benefit over placebo for some: https://t.co/UJUj1Ga7Re #PainMedicine #AcutePain #Opioids
Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/IV7X0rQgzg #stopthepain

Phase 3 ALLEVIATE trials: cebranopadol (dual NOP/MOP) cut post-op pain and slashed need for rescue opioids vs placebo, with favorable safety. Could bridge the pain-treatment gap. https://t.co/rnqGAfzsjA #PainManagement #AcutePain #AAPM2026

Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/IV7X0rQgzg #stopthepain

Acute pain is the body's alarm system, telling us of injury, infection & more. But if you don't shut it down, it can become something worse. Check out @ForGrace's #AcutePain Campaign to make your plan of action https://t.co/IV7X0rQgzg #stopthepain

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