Top Tweets for #ALSM
#Myeloma Paper of the Day: Transcriptome analysis of AL #amyloidosis pt myocardial samples finds upregulation of fibroblast activation genes (e.g. collagen type I/III & periostin), fibroblast-to-myofibroblast transition in vitro & matrix remodeling: https://t.co/re73ymwdq3. #alsm
#Myeloma Paper of the Day: Systematic review & meta-analysis of diagnostic accuracy of fat pad & BM sampling for AL #amyloidosis finds fat pad & surgical/punch bx w/ similar sensitivity (0.80 & 0.77, respectively); one study w/ both yielded 0.89: https://t.co/q1E2yFsimg. #alsm
#Myeloma Paper of the Day: Limited duration (≤3 months) of dexamethasone in newly diagnosed AL #amyloidosis (w/ daratumumab-based regimen) results in higher 6-month CR rates (66.7 vs 30.4%, p<0.001) and reduced toxicity, similar organ responses: https://t.co/K47TNcIWu5. #alsm
#Myeloma Paper of the Day: Catheter ablation for atrial fib in transthyretin & AL cardiac #amyloidosis -> 42% freedom from atrial arrhythmia after 2-year f/u; persistent AF recurrence has 3-fold higher risk of heart failure hospitalization & death: https://t.co/vWCB5b1fiF. #alsm
#Myeloma Paper of the Day: Study of fat aspiration for diagnosis/screening of #amyloidosis in 2830 patients from 2013 to 2020: finds compelling sensitivity for AL and better sensitivity in females for all major subtypes: https://t.co/NLnYN5DCke. #alsm
#Myeloma Paper of the Day: Multicenter study of ASCT for AL #amyloidosis (2010-20) finds median OS 6.3 yrs; inferior survival if age ≥60, BMPCs ≥20%, pre-ASCT dFLC ≥40, elevated cardiac markers, lambda dz, reduced eGFR, reduced-dose conditioning: https://t.co/KRBX3cSeuU. #alsm
#Myeloma Paper of the Day: Study of long-term outcomes of Mayo stage IIIb AL #amyloidosis treated w/ daratumumab-based frontline therapy finds improved survival vs. pre-daratumumab cohorts (median OS 12.9 vs 4–6 months): https://t.co/3jRgwArUbl. #alsm
#Myeloma Paper of the Day: Retrospective German Society for Amyloid Diseases study of teclistamab in relapsed/refractory AL #amyloidosis finds ≥VGPR in 95% @ 3 mos, cardiac & renal ≥PR @ 6 mos were 65% & 78%, lower infxn & death rate w/ IV Ig: https://t.co/tMUzgkWkn9. #alsm
#Myeloma Paper of the Day: Randomized CARES trial of anti-fibril antibody anselamimab in AL #amyloidosis did not meet primary end point in overall population but improved all-cause mortality cardiovascular hospitalizations in patients with kappa AL: https://t.co/939temEkIR. #alsm
#Myeloma Paper of the Day: Claims linked electronic health record database analysis finds overall & advanced AL/light chain #amyloidosis patients face high economic burden, supporting continued need for therapeutic advances to help this population: https://t.co/d1XPfP2lFO. #alsm
#Myeloma Paper of the Day: Predictors of deep renal response (>60% proteinuria reduction or ≤200 mg) in AL #amyloidosis post-anti-plasma cell tx include obtaining ≥HemVGPR in 6 mos, kappa isotype, dFLC ≥40 mg/dL, renal stage and undergoing ASCT: https://t.co/KTPBnSBpMv. #alsm
#Myeloma Paper of the Day: Systematic review & meta-analysis concludes immunofixation (SIFE & UIFE) & sFLC ratio combined give sensitivity of 0.99 (0.96-1.00)) as reliable initial testing strategy to raise suspicion of diagnosis of AL #amyloidosis: https://t.co/wtDJaMdgWR. #alsm
Our data on T/Myeloid bZIP CEBPA mutation @TheIACH meeting 2025 today at Paris.
This group of MPALs are biologically different!
#iach #iach25
#alsm
@bagalbp
@udaypkulkarni @ManjuSengar7 @DrNikitaMehra @TataMemorial
🚀❄️ Welcome to AlaskaSummit (ALSM) — the ice-cold token with hot profits!
Marking the historic Trump-Putin meeting in Alaska 2025.
Join the Arctic climb and be part of the summit! 🌨️🔥
#ALSM #Crypto #AlaskaSummit #CryptoNews
#Myeloma Paper of the Day: Ethnicity in systemic AL #amyloidosis may impact risk stratification, w/ ethnic minority pts presenting at a younger age, a lower NT-proBNP and worse global longitudinal strain despite a similar LV wall thickness: https://t.co/xeo7EeJbzR. #mmsm #alsm
#Myeloma Paper of the Day: Retrospective review of end-stage cardiac #amyloidosis pts who underwent hear transplantation @ Mayo Clinic (1/2007-12/2020) finds no significant overall survival difference in amyloid vs. non-amyloid (p = 0.816): https://t.co/XeXQ4mJt6n. #mmsm #alsm
@ArtOfDialogue_ @MOON09202000 #MichaelJackson produced on average 100 songs per album. Only 15 to 20 actually made the albums. The rest was practice, skill honing. This is why musicians tend to be great students. The same technique is applied to studying for any subject. #ALSM #MD
@BBCNews Either way it goes if you study how it is formed you can reverse it to slow it down therefore possibly reducing the amount of damage it will cause. The same techniques used to do cloud seeding should be able to be used to reduce hurricanes. #FORBES #GODDESSISIS #ALSM
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