Top Tweets for #AwakeMice
#awakemice, meet your six-legged cousin: #awakeflies! 🪰
Using VR olfaction in head-fixed #Drosophila, Ruta Lab @RockefellerUniv shows flies track an odour plume by following its boundary: quick exits, directed returns. FC2 neurons signal the way back 🧭 https://t.co/qxpzzjI2G5
Do all cortical layers hear noise the same way? 🤔
Using #twophoton in #awakemice auditory Cx, Suarez & Williamson @CarnegieMellon show deep-layer L5 IT neurons keep sound representations noise-invariant, while superficial L2/3 stay noise-dependent 👏👏
https://t.co/7TkDR5irbO
FENS Booth 10: Head fixation gets all the attention, but spinal cord imaging in awake mice is an even greater challenge. The #MobileHomeCage handles both. #FENS2026 #spinalcord #awakemice
Less than 24 hours left to grab free head plate samples #FENS2026! Running #twophoton, #fUSi, or #electrophysiology in #awakemice? Swing by Neurotar booth 10 before 2PM tomorrow!
Can opioid efficacy be read from brain connectivity? ⚡️
Using #fUS in #awakemice @ZsoltLenkei established an opioid-specific functional connectivity fingerprint as a reliable biomarker of opioid efficacy! July 8, PS03 #FENS2026
https://t.co/gE6CZz0YTy
Astrocyte biology is back in the spotlight of #epilepsy research. New preprint from @LabWykes: knocking out a single astrocyte potassium channel in the hippocampus is enough to trigger spontaneous seizures - & make them worse. #ephys #epilepsy #awakemice https://t.co/XJIJMs2TU9
Pupil dilation has a cortical signature! 👁️
Morita Lab @KobeU_Global combines widefield Ca²⁺ imaging & explainable machine learning in head-fixed #awakemice to decode pupil-linked arousal from cortical activity 👏👏👏
https://t.co/qPreTsAMqN
Ramping activity and time!⏱️
Using #ephys in freely-moving & head-fixed #awakemice in the #MobileHomeCage, @aldridge_lab shows prefrontal neuronal ramping and ~4 Hz theta activity may be features of interval timing rather than motor programs 👏👏👏
https://t.co/iJjo1gG4ce
Aging ears, aging cortex! ⌛️🧠
Using #twophoton imaging in #awakemice, Chen & Kanold @JohnsHopkins show that auditory cortex L2/3 loses selectivity to harmonic sounds & temporal integration of component frequencies with age👏👏👏
https://t.co/ViMijp9fj9
Motor cortex is selectively recruited by context!🧠
Using #ephys & whisker stimulation in #awakemice, @SachdevRobert lab shows that vM1 neurons respond strongly to passive whisker stimulation but are barely engaged during active goal-directed whisking 👏👏
https://t.co/6k8vZ3EBm3
Astrocytes in the driver's seat!🧠
Using #twophoton in head-fixed #awakemice, @BrunoWeberLab & colleagues show disrupting astrocyte activity during adolescent PFC maturation leads to synaptic loss, PV interneuron deficits & behavioral impairments 👏👏👏
https://t.co/ug7qHvF8fP
Don't skip core day, your brain will notice!😉
Researchers at @PennUniversity show abdominal contractions, not heartbeat or respiration, physically move the brain inside the skull in head-fixed #awakemice! 👏👏👏
https://t.co/dwavrgeFB4
Opioids’ fingerprint! ⚡️
Using #fUSI in #awakemice, @SamuelDiebolt @ZsoltLenkei & team show opioids produce a functional connectivity fingerprint that scales with agonist efficacy and disappears with receptor inactivation 👏👏👏
@iconeus #MobileHomeCage https://t.co/FlFeIhmtl7
Mesoscale brain imaging just got a major upgrade.
@mengke_yang & colleagues built ULTRA, a #twophoton microscope with >50mm² FOV, spanning 7mm across cortical regions at single-cell resolution, down to 900µm deep, tested in #awakemice👏👏👏 https://t.co/kEEqI5lAXw
Short-term plasticity, long-term consequences?🤔
Using #ephys in #awakemice, @CathMarneffe et al. show that deleting Syt7 at Mf synapses suppresses short-term presynaptic facilitation, disrupts CA3 co-activity & impairs pattern completion in memory tasks!
https://t.co/bbylKHoa3L
Different inhibitory tunes! 🧠🎶
Using #optogenetics & #electrophysiology in #awakemice, @solyrol & Geffen lab show PV and SST reticular thalamic neurons target distinct auditory subregions and oppositely modulate sound-evoked activity! 👏👏
https://t.co/NnRd5EhZUr
A window into β-cell dynamics in #awakemice.
Tröster & Köhler (@karolinskainst) use the dura mater as a transplantation site to track pancreatic islets longitudinally, revealing vascular integration and preserved metabolic function!
Webinar, March 26 → https://t.co/yl63lYBNSR
2 preprints from @EmilieMaceLab! 👏👏
Using #fUS in #awakemice, they uncover a transition-prone brain state preceding spontaneous behavior & an arousal initiated brain-wide wave independent of LC noradrenergic tone! Check them out:
https://t.co/G4ZrEOcyTO
https://t.co/rWCnLmlYjr
Imaging pancreatic islets. Why use the brain as a medium?
Tröster & Köhler (@karolinskainst) show how β-cell activity can be tracked longitudinally in #awakemice. Implications extend beyond diabetes to organoids March 26: https://t.co/yl63lYBNSR
#Neuroscience #Organoids #Diabetes
After transplantation into dura matter, pancreatic islets become metabolically active and vascularized!
March 26: Tröster & Köhler (@karolinskainst) show how to image pancreatic cells in #awakemice: https://t.co/yl63lYBNSR
#Neuroscience #Diabetes #CalciumImaging
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