Top Tweets for #AxonalInjury
Compressive Neuropathy: When Pressure Finds the Vulnerable
#CompressiveNeuropathy #PressurePalsy #EntrapmentNeuropathy #Neuropraxia #Demyelination #AxonalInjury #Hypothyroidism #DiabetesNeuropathy #PositioningMatters #RegionalAnesthesia #PostoperativeNeuropathy #AnatomyMatters
#TipOfTheDay #MyRATips
Tip of the Day:
๐ง Pathology - What Really Happens?
๐น Sustained mechanical pressure โ structural deformation
๐น Endoneurial capillary collapse โ ischemia
๐น Intraneural edema โ rising compartment pressure
๐น Early phase โ conduction block (neuropraxia)
๐น Prolonged compression โ segmental demyelination
๐น Severe/untreated โ axonal degeneration
๐น Metabolic disorders (e.g., hypothyroidism, diabetes) โ reduced tolerance to pressure
Core Formula:
Pressure ร Duration ร Susceptibility = Dysfunction
โ ๏ธ Risk Factors - Who Is Prone?
๐ธ Prolonged posture (kneeling, lithotomy, leg crossing)
๐ธ Rapid weight loss (loss of protective padding)
๐ธ Diabetes mellitus
๐ธ Hypothyroidism
๐ธ Rheumatoid arthritis
๐ธ Pregnancy / fluid retention states
๐ธ Tight casts, splints, tourniquets
๐ธ Repetitive occupational positioning
๐ธ ICU immobilization
๐ฉบ Clinical Clues - What Raises Suspicion?
๐น Sudden weakness after sustained posture
๐น Focal motor deficit > sensory symptoms
๐น Symptoms appearing after surgery or prolonged positioning
๐น Normal proximal function with distal weakness
๐น History of metabolic vulnerability
โณ Prognosis - What to Expect?
๐ข Neuropraxia โ recovery in weeks
๐ก Demyelination โ recovery in months
๐ด Axonal injury โ prolonged or incomplete recovery
๐ต Early identification dramatically improves outcome
Golden principle: The earlier the decompression, the better the recovery.
๐ Treatment - What To Do?
๐ Remove compression source
๐๏ธ Correct posture and ergonomics
๐ Optimize thyroid, glucose, metabolic status
๐ง Reduce edema
๐ฆฟ Splinting to prevent contractures
๐๏ธ Targeted physiotherapy
๐ช Surgical decompression in selected chronic entrapments
๐ฏ Regional Anesthesia Implications
๐ฉป Pre-Block Assessment
๐น Screen for diabetes, hypothyroidism, neuropathy history
๐น Document baseline motor & sensory status
๐น Identify preexisting deficits clearly
๐ช Positioning Matters
๐ธ Avoid prolonged extreme flexion or compression during block
๐ธ Protect superficial structures near bone
๐ธ Reassess padding in sedated patients
๐ธ Extra vigilance in lithotomy and long procedures
๐ Block Considerations
๐น Avoid high injection pressures
๐น Use ultrasound to minimize intraneural injection risk
๐น Be cautious with dense motor blocks in high-risk patients
๐น Consider lower concentration when appropriate
โ๏ธ Postoperative Dilemma
๐ธ New deficit after surgery?
โ Is it surgical?
โ Position-related?
โ Block-related?
โ Metabolic vulnerability unmasked?
๐น Early differentiation prevents unnecessary blame on the block.
๐จ Medicolegal Insight
โจ Many postoperative neuropathies are positional or compressive - not anesthetic toxicity.
โจ Proper documentation protects both patient and anesthesiologist.
๐ก High-Yield Pearls
โจ Metabolic disease lowers pressure tolerance.
โจ Sedation hides warning symptoms.
โจ Compression + duration is more dangerous than brief intense pressure.
โจ Not every postoperative weakness is โblock-related.โ

๐ฅScientists just discovered that a "secondary" injury response might be key to nerve #regeneration! Stress signaling after axon injury activates pathways that could help repair the central nervous system. #Neuroscience #AxonalInjury
https://t.co/tph14eCmkL
Our new paper: Even with a helmet, high-energy blunt trauma can lead to fatal respiratory failure. Our study maps specific brainstem injury patterns, revealing critical implications for #TBI & protection. Patterns of #vascularinjury โ #axonalinjury https://t.co/zEf2UqlOnp
Axonal injury is detected by ฮฒAPP immunohistochemistry in rapid death from head injury following road traffic collision
Keywords: #axonalinjury #IHC #headinjury #ฮฒAPP
https://t.co/MdgvKt7E6p

#STROKE #AxonalInjury partially mediates associations between increased #LeftVentricular mass index and #WhiteMatter damage #Biomarkers #Aging #SmallVesselDisease https://t.co/o4987V83zv @EMoore1225 @timothyjhohman @AJtheScientist @VanderbiltAlz

#MetabolicCascade #AxonalInjury #NeurotransmitterDysfunction #GlymphaticSystem โ some of the #mTBI #TBI topics Iโm excited to discuss at the @A4MEvents Virtual #BrainHealth Summit June 26-27: https://t.co/r8T43m3uVo
A glycolytic shift in Schwann cells supports injured axons, @ElisabettaBabe1 et al, @Jacobs_Med_UB: @ubhjkri, @UBPharmTox, @UBuffalo #Biochemistry |@NatureNeuro
https://t.co/TWa4IWAW2K
Summary
https://t.co/nDUvJrXWvN
#axonalinjury #axons #Schwanncells #glycolysis #neuroscience

My latest work has now been published on the Journal of Biomechanical Engineering by @ASMEJournals: https://t.co/0zZYlI3B31! Here we propose a computational approach to assess the onset of mechanoporation.
Thanks to @RR_Amini for having been a great editor!

Traumatic #axonalinjury causes strain-dependent ion influx. #DrDougSmith @PennMedicine @AANMember #Sports #Concussion Conf. #AANSCC @Neurotrauma @NeuroTrauma18 @TheNewANA1 @neuropathology @WillStewNeuro @Penn #DAI #TAI #TBI
https://t.co/RR5PjyOcAQ

Diffuse #axonalinjury #DAI after #concussion #mTBI may be subtle for conventional imaging. #DrDougSmith @PennMedicine @AANMember #Sports Concussion Conf. #AANSCC @Neurotrauma @NeuroTrauma18 @TheNewANA1 @neuropathology @WillStewNeuro @Penn

I uploaded a new episode, "Episode XII Dr. Willie Stewart PhD Part I: Role of the Neuropathologist & CTE in the Media", on #spreaker #athletes #axonalinjury #axons #brain #braininjury #concussion #concussions #cte #foamed #meded #neurons #neuropathology https://t.co/ixnE73aGbB
Diane Snow, Ph.D.; proteoglycans #CSPGs and CNS injury; great seminar @GUNeuro #IPN #axonalinjury #gliascar #neuroscience #SCI #TBI

Increased CSF NF-L correlates with post #concussion symptoms; #biomarker #axonalinjury
https://t.co/qV8CeF0tpO

#DrRebekahMannix #cisTau seen w mouse #mTBI; repeat mTBI more cisTau, assoc w #AxonalInjury & it spreads. #AANSCC

.@Neurotrauma 16 #NNS16 Day1 workshops! 3of6 #AxonalInjury, #Preclincal models, Devel & Aging @SfNtweets @INTS2016

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