#AxonalInjury - Twitter Hashtag

4 months ago

Compressive Neuropathy: When Pressure Finds the Vulnerable #CompressiveNeuropathy #PressurePalsy #EntrapmentNeuropathy #Neuropraxia #Demyelination #AxonalInjury #Hypothyroidism #DiabetesNeuropathy #PositioningMatters #RegionalAnesthesia #PostoperativeNeuropathy #AnatomyMatters #TipOfTheDay #MyRATips Tip of the Day: 🧠 Pathology - What Really Happens? 🔹 Sustained mechanical pressure → structural deformation 🔹 Endoneurial capillary collapse → ischemia 🔹 Intraneural edema → rising compartment pressure 🔹 Early phase → conduction block (neuropraxia) 🔹 Prolonged compression → segmental demyelination 🔹 Severe/untreated → axonal degeneration 🔹 Metabolic disorders (e.g., hypothyroidism, diabetes) → reduced tolerance to pressure Core Formula: Pressure × Duration × Susceptibility = Dysfunction ⚠️ Risk Factors - Who Is Prone? 🔸 Prolonged posture (kneeling, lithotomy, leg crossing) 🔸 Rapid weight loss (loss of protective padding) 🔸 Diabetes mellitus 🔸 Hypothyroidism 🔸 Rheumatoid arthritis 🔸 Pregnancy / fluid retention states 🔸 Tight casts, splints, tourniquets 🔸 Repetitive occupational positioning 🔸 ICU immobilization 🩺 Clinical Clues - What Raises Suspicion? 🔹 Sudden weakness after sustained posture 🔹 Focal motor deficit > sensory symptoms 🔹 Symptoms appearing after surgery or prolonged positioning 🔹 Normal proximal function with distal weakness 🔹 History of metabolic vulnerability ⏳ Prognosis - What to Expect? 🟢 Neuropraxia → recovery in weeks 🟡 Demyelination → recovery in months 🔴 Axonal injury → prolonged or incomplete recovery 🔵 Early identification dramatically improves outcome Golden principle: The earlier the decompression, the better the recovery. 💊 Treatment - What To Do? 🛑 Remove compression source 🛏️ Correct posture and ergonomics 💉 Optimize thyroid, glucose, metabolic status 🧊 Reduce edema 🦿 Splinting to prevent contractures 🏋️ Targeted physiotherapy 🔪 Surgical decompression in selected chronic entrapments 🎯 Regional Anesthesia Implications 🩻 Pre-Block Assessment 🔹 Screen for diabetes, hypothyroidism, neuropathy history 🔹 Document baseline motor & sensory status 🔹 Identify preexisting deficits clearly 🪑 Positioning Matters 🔸 Avoid prolonged extreme flexion or compression during block 🔸 Protect superficial structures near bone 🔸 Reassess padding in sedated patients 🔸 Extra vigilance in lithotomy and long procedures 💉 Block Considerations 🔹 Avoid high injection pressures 🔹 Use ultrasound to minimize intraneural injection risk 🔹 Be cautious with dense motor blocks in high-risk patients 🔹 Consider lower concentration when appropriate ⚖️ Postoperative Dilemma 🔸 New deficit after surgery? → Is it surgical? → Position-related? → Block-related? → Metabolic vulnerability unmasked? 🔹 Early differentiation prevents unnecessary blame on the block. 🚨 Medicolegal Insight ✨ Many postoperative neuropathies are positional or compressive - not anesthetic toxicity. ✨ Proper documentation protects both patient and anesthesiologist. 💡 High-Yield Pearls ✨ Metabolic disease lowers pressure tolerance. ✨ Sedation hides warning symptoms. ✨ Compression + duration is more dangerous than brief intense pressure. ✨ Not every postoperative weakness is “block-related.”

KartikBSonawane's tweet photo. Compressive Neuropathy: When Pressure Finds the Vulnerable

#CompressiveNeuropathy #PressurePalsy #EntrapmentNeuropathy #Neuropraxia #Demyelination #AxonalInjury #Hypothyroidism #DiabetesNeuropathy #PositioningMatters #RegionalAnesthesia #PostoperativeNeuropathy #AnatomyMatters
#TipOfTheDay #MyRATips

Tip of the Day:

🧠 Pathology - What Really Happens?

🔹 Sustained mechanical pressure → structural deformation
🔹 Endoneurial capillary collapse → ischemia
🔹 Intraneural edema → rising compartment pressure
🔹 Early phase → conduction block (neuropraxia)
🔹 Prolonged compression → segmental demyelination
🔹 Severe/untreated → axonal degeneration
🔹 Metabolic disorders (e.g., hypothyroidism, diabetes) → reduced tolerance to pressure
Core Formula:
Pressure × Duration × Susceptibility = Dysfunction

⚠️ Risk Factors - Who Is Prone?

🔸 Prolonged posture (kneeling, lithotomy, leg crossing)
🔸 Rapid weight loss (loss of protective padding)
🔸 Diabetes mellitus
🔸 Hypothyroidism
🔸 Rheumatoid arthritis
🔸 Pregnancy / fluid retention states
🔸 Tight casts, splints, tourniquets
🔸 Repetitive occupational positioning
🔸 ICU immobilization

🩺 Clinical Clues - What Raises Suspicion?

🔹 Sudden weakness after sustained posture
🔹 Focal motor deficit > sensory symptoms
🔹 Symptoms appearing after surgery or prolonged positioning
🔹 Normal proximal function with distal weakness
🔹 History of metabolic vulnerability

⏳ Prognosis - What to Expect?

🟢 Neuropraxia → recovery in weeks
🟡 Demyelination → recovery in months
🔴 Axonal injury → prolonged or incomplete recovery
🔵 Early identification dramatically improves outcome

Golden principle: The earlier the decompression, the better the recovery.

💊 Treatment - What To Do?

🛑 Remove compression source
🛏️ Correct posture and ergonomics
💉 Optimize thyroid, glucose, metabolic status
🧊 Reduce edema
🦿 Splinting to prevent contractures
🏋️ Targeted physiotherapy
🔪 Surgical decompression in selected chronic entrapments

🎯 Regional Anesthesia Implications

🩻 Pre-Block Assessment
🔹 Screen for diabetes, hypothyroidism, neuropathy history
🔹 Document baseline motor & sensory status
🔹 Identify preexisting deficits clearly

🪑 Positioning Matters
🔸 Avoid prolonged extreme flexion or compression during block
🔸 Protect superficial structures near bone
🔸 Reassess padding in sedated patients
🔸 Extra vigilance in lithotomy and long procedures

💉 Block Considerations
🔹 Avoid high injection pressures
🔹 Use ultrasound to minimize intraneural injection risk
🔹 Be cautious with dense motor blocks in high-risk patients
🔹 Consider lower concentration when appropriate

⚖️ Postoperative Dilemma
🔸 New deficit after surgery?
→ Is it surgical?
→ Position-related?
→ Block-related?
→ Metabolic vulnerability unmasked?

🔹 Early differentiation prevents unnecessary blame on the block.

🚨 Medicolegal Insight

✨ Many postoperative neuropathies are positional or compressive - not anesthetic toxicity.
✨ Proper documentation protects both patient and anesthesiologist.

💡 High-Yield Pearls

✨ Metabolic disease lowers pressure tolerance.
✨ Sedation hides warning symptoms.
✨ Compression + duration is more dangerous than brief intense pressure.
✨ Not every postoperative weakness is “block-related.”

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stmpub @STMPUB

about 1 year ago

💥Scientists just discovered that a "secondary" injury response might be key to nerve #regeneration! Stress signaling after axon injury activates pathways that could help repair the central nervous system. #Neuroscience #AxonalInjury https://t.co/tph14eCmkL

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Athanasios Alexandris, MBChB @a_alexandris

over 1 year ago

Our new paper: Even with a helmet, high-energy blunt trauma can lead to fatal respiratory failure. Our study maps specific brainstem injury patterns, revealing critical implications for #TBI & protection. Patterns of #vascularinjury ≠ #axonalinjury https://t.co/zEf2UqlOnp

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London Neurodegenerative Diseases Brain Bank @LNDBrainBank

over 3 years ago

Axonal injury is detected by βAPP immunohistochemistry in rapid death from head injury following road traffic collision Keywords: #axonalinjury #IHC #headinjury #βAPP https://t.co/MdgvKt7E6p

LNDBrainBank's tweet photo. Axonal injury is detected by βAPP immunohistochemistry in rapid death from head injury following road traffic collision

Keywords: #axonalinjury #IHC #headinjury #βAPP

https://t.co/MdgvKt7E6p https://t.co/jmrDd0quXK

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Stroke AHA/ASA @StrokeAHA_ASA

about 4 years ago

#STROKE #AxonalInjury partially mediates associations between increased #LeftVentricular mass index and #WhiteMatter damage #Biomarkers #Aging #SmallVesselDisease https://t.co/o4987V83zv @EMoore1225 @timothyjhohman @AJtheScientist @VanderbiltAlz

StrokeAHA_ASA's tweet photo. #STROKE #AxonalInjury partially mediates associations between increased #LeftVentricular mass index and #WhiteMatter damage #Biomarkers #Aging #SmallVesselDisease https://t.co/o4987V83zv @EMoore1225 @timothyjhohman @AJtheScientist @VanderbiltAlz https://t.co/iGbCbTqMWb

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Vernon Williams, MD @VernWilliamsMD

almost 5 years ago

#MetabolicCascade #AxonalInjury #NeurotransmitterDysfunction #GlymphaticSystem – some of the #mTBI #TBI topics I’m excited to discuss at the @A4MEvents Virtual #BrainHealth Summit June 26-27: https://t.co/r8T43m3uVo

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Autonomic Aus @AutonomicAus

almost 6 years ago

A glycolytic shift in Schwann cells supports injured axons, @ElisabettaBabe1 et al, @Jacobs_Med_UB: @ubhjkri, @UBPharmTox, @UBuffalo #Biochemistry |@NatureNeuro https://t.co/TWa4IWAW2K Summary https://t.co/nDUvJrXWvN #axonalinjury #axons #Schwanncells #glycolysis #neuroscience

AutonomicAus's tweet photo. A glycolytic shift in Schwann cells supports injured axons, @ElisabettaBabe1 et al, @Jacobs_Med_UB: @ubhjkri, @UBPharmTox, @UBuffalo #Biochemistry |@NatureNeuro

https://t.co/TWa4IWAW2K

Summary
https://t.co/nDUvJrXWvN

#axonalinjury #axons #Schwanncells #glycolysis #neuroscience https://t.co/afifYoL9q9

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NeuronicKTH @Neuronic_KTH

over 6 years ago

Good way to celebrate #MyTwitterAnniversary: @AnnacMont's paper is out! #TBI #DAI #AxonalInjury

AnnaclaudiaMontanino @AnnacMont

over 6 years ago

My latest work has now been published on the Journal of Biomechanical Engineering by @ASMEJournals: https://t.co/0zZYlI3B31! Here we propose a computational approach to assess the onset of mechanoporation. Thanks to @RR_Amini for having been a great editor!