Top Tweets for #BaseEditors
Check-out this article from the #IZFS #NewsSplash #ScienceSpotlight! "C-ing clearly: high-efficiency base editors for modelling previously unresolved disease variants"
Read it here: https://t.co/9yTDvuaIip
#diseasevariants #baseeditors
Beam Designs New Approach for Direct Correction of Mutations Causing PKU
@BeamTx is advancing BEAM-304 using an approach in which multiple mutation-specific #baseeditors are developed within a single clinical program
@john_evans3
#geneticdiseases #PKU
https://t.co/YSz98KYSu3
Exciting new #research from the Patel lab published in @jclinicalinvest using #BaseEditors to rescue #seizures and #SUDEP in a mouse model of #SCN8A #R1872W Developmental Epileptic Encephalopathy #DEE @MedicineUVA #EpilepsyResearch #CUTESyndromeFoundation
https://t.co/UTTosGs7ob
CHANGE-seq-BE Developed to Allow Scientists to Better Understand Base Editors
CHANGE-seq-BE was developed to enable scientists to better understand #baseeditors, an important class of #CRISPR precise genome editors
@shengdarqtsai @StJudeResearch
#DNA
https://t.co/Kw8QSVgXqU
#A new method, CHANGE-seq-BE, enables unbiased, sensitive, and efficient detection of off-target genome changes from #BaseEditors, advancing safety assessment in precision genome editing. @NatureBiotech https://t.co/B9uLUNXFpC https://t.co/FFt5iyuLee
Base Editors make double-stranded brakes and chromosome rearangements
#ESGCT2025 #BaseEditors #OffTagets
Our article "Genome-scale exon perturbation screens uncover exons critical for cell fitness" is featured and most read at @MolecularCell. @TGonatopoulos @NCIResearchCtr @NIH @theNCI
#RNA #Splicing #CRISPR #Cas9, #Cas12a, #BaseEditors #ABE #CBE #exon #essential #machinelearning
Development of multiplexed orthogonal base editor (MOBE) systems. #BaseEditors #PointMutations @NatureBiotech
https://t.co/ZaPCkFuZut
#EBMT24, I know I need2know and learn this slide differences between #CRISPR/Cas9 vs #BaseEditors #basics of #GeneTherapy
☕️In this issue: @FeilongM, Yeap & co profile #DoubleStrandBreaks (DSBs) generated by C-to-G #BaseEditors (CGBEs) and find that HMCES protects abasic sites and reduces CGBE-triggered DSBs.
👉🏿https://t.co/7nRpsg2jjC
https://t.co/biEPVGvp9i
👋🏾Our February issue's live!
Cover: #HumanEmbryo arrest
👉🏼Turning point series celebrating our 25-year anniversary
👉🏿🔬 on: #mechanobiology #cGASSTING #lysosomeDisease #SmallIntestine #LipidMetabolism #diapause #ReplicationStress #BaseEditors #lipidomics
https://t.co/tKgTmRGnVi
💫NEW: @FeilongM, Yeap & co profile #DoubleStrandBreaks (DSBs) generated by C-to-G #BaseEditors (CGBEs) and find that HMCES protects abasic sites and reduces CGBE-triggered DSBs.
👉🏽https://t.co/7nRpsg2jjC
https://t.co/biEPVGvp9i
Beam Therapeutics reports dosing of the first patient with BEAM-201, a base-edited allogeneic CAR-T cell candidate developed to treat certain aggressive CD7+ blood cancers.
Read here: https://t.co/alJFXALj8j
#crisprmedicinenews #crisprmedicine #geneediting #baseeditors #cancer
#NewNProt: Precise #mutagenesis in #zebrafish using cytosine #baseeditors https://t.co/jSrbeBYRdh @filodelbene @Marion_Rosello
#PublicationFriday📚 #SCGE PI @davidrliu reports the development of compact zinc-finger #baseeditors that edit mitochondrial or nuclear DNA in human cells and in animals.
https://t.co/MNAFsHLxeL
12.Together, these experiments highlight the versatility of #SpRY #baseeditors and how they can be leveraged to develop a potential long-lasting genetic treatment for SMA. *So many* new avenues stemming from this work in #techdev, #delivery, #SMA, & #otherdiseases.
1.Excited to share our 1⃣ @biorxivpreprint of 23 on the optimization of base editing as a genetic treatment for spinal muscular atrophy (#SMA). We demonstrate the versatility, efficacy, and safety of #baseeditors in SMA cells and in vivo in SMA mice. https://t.co/pS7RIXAQ9K
7/@BeamTx has also decided to forgo $BEAM-102 IND & to optimize its programs for future SCD waves by enabling an improved, reduced-toxicity conditioning regimen for #patients undergoing HSC transplantation & its Wave 3 strategy - focusing on in vivo delivery of #baseeditors.
Great discussion topics at Day 2 of #SCGE22 🧬
#genetherapy #noveleditors #baseeditors #biodistribution
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