#CCR4 - Twitter Hashtag

over 1 year ago

In typical cellular models (HEK293T), we observed that mRNA-1273 degradation is initiated via removal of the terminal pentamer (mΨCmΨAG), followed by #CCR4-NOT-mediated #deadenylation—the canonical #mRNA #decay pathway. (6/n) #RNAMetabolism

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In Honour Of Thomas W Phelps

@HOThomasWPhelps

almost 2 years ago

Liver failure in $RAPT Ph2 study led to clinical hold and canceled trial likely due to the #CCR4 antagonist MOA. Disrupting CCR4 complex is known to cause lethal hepatitis and is unique to RAPT molecule and its mechanism of action. https://t.co/A5tTlhZ3OV

HOThomasWPhelps's tweet photo. Liver failure in $RAPT Ph2 study led to clinical hold and canceled trial likely due to the #CCR4 antagonist MOA.
Disrupting CCR4 complex is known to cause lethal hepatitis and is unique to RAPT molecule and its mechanism of action.
https://t.co/A5tTlhZ3OV https://t.co/2iOrVk1Utb

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In Honour Of Thomas W Phelps

@HOThomasWPhelps

almost 2 years ago

1 of 2 In 2021 $RAPT #CCR4 antagonist atopic dermatitis: - upstream #Th2 MOA reduced SEVERAL cytokines - CCR4 on #Treg cells/trafficked Tregs to skin - treatment ended but improvement cont, long-lasting! - Unfortunatlely CCR4 on #platelets likely cause of liver toxicity in Ph2

HOThomasWPhelps's tweet photo. 1 of 2 In 2021 $RAPT #CCR4 antagonist atopic dermatitis:
- upstream #Th2 MOA reduced SEVERAL cytokines
- CCR4 on #Treg cells/trafficked Tregs to skin
- treatment ended but improvement cont, long-lasting!
- Unfortunatlely CCR4 on #platelets likely cause of liver toxicity in Ph2 https://t.co/Ip1HOgJEI1

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Haematologica @Haematologica

over 2 years ago

Clinicians can personalize their approach and select the most appropriate histone deacetylase inhibitor to enhance or maintain #CCR4 expression in adult #T-cell #leukemia/lymphomaCells https://t.co/qMTuBRhv0X

Haematologica's tweet photo. Clinicians can personalize their approach and select the most appropriate histone deacetylase inhibitor to enhance or maintain #CCR4 expression in adult #T-cell #leukemia/lymphomaCells
https://t.co/qMTuBRhv0X https://t.co/Qzk6SpkxpJ

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Emma Guttman-Yassky

@EmmaGuttman

almost 3 years ago

So proud of my team's work on this novel oral treatment targeting CCR4. This is the first chemokine receptor targeting going into AD and into inflammatory conditions! #CCR4 #treatment #novel #atopic #chemokine #mountsinai #Science #Research https://t.co/lgO8BFsoLn

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Pawel Krawczyk @pakraw

over 3 years ago

@nanopore @moderna_tx We confirmed fast decay of #vaccine #mRNA in model cell lines, mediated by #CCR4-NOT #deadenylation 3/n

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Milo B. Fasken, Ph.D. (he/him) @MiloFasken

about 4 years ago

#CCR4 #GotDeadenylation #RNA 😊

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@derm_ce @derm_ce

over 4 years ago

34) New data on #JAKi for #AD were otherwise thin at #AAD2022. There were new data on #eblasakimab,a first-in-class monoclonal antibody that targets the IL-13 receptor α1 subunit (IL-13Rα1), #difelikefalin, a kappa opioid receptor agonist, and #RPT193, a novel #CCR4 inhibitor.

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Tomoki MOTEGI🧬 @MotegiTomoki

over 4 years ago

前立腺がん、ちゃっかり英語のニュースも引用しておく（笑） https://t.co/ZQN4tTAzJo 日本語のプレスリリースも後でリンク貼りますね（忙しい方はそちらから） #ProstateCancer #CCR4 #AnimalModel

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QLifePro医療情報 @QLife_JP

almost 6 years ago

末梢性T細胞リンパ腫発症にVAV1遺伝子変異が関与－筑波大ほか #CCR4 #MYC https://t.co/j3nWxcZanO

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Maurizio Miliziano

@Miliziano_M

over 6 years ago

#Rap Spa, oggi inaugurato il 4 #centro #comunale di #raccolta (#CCR4) denominato "#Oreto" bretella laterale direzione #Palermo - #Catania pressi rotonda Oreto . Il CCR sarà aperto tutti i giorni dalle ore 7 alle ore 17 e la domenica fino alle ore 13. #noswaste #zerorifiuti

Miliziano_M's tweet photo. #Rap Spa, oggi inaugurato il 4 #centro #comunale di #raccolta (#CCR4) denominato "#Oreto" bretella laterale direzione #Palermo - #Catania pressi rotonda Oreto .
Il CCR sarà aperto tutti i giorni dalle ore 7 alle ore 17 e la domenica fino alle ore 13. #noswaste #zerorifiuti https://t.co/yWJc1CGPeJ

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Cancer Immunology Research @CIR_AACR

about 7 years ago

Targeting #CCR4 on #Tregs affects clinical responses and survival in a spontaneous #BladderCancer #CanineModels. #ImmuneBlockade https://t.co/Rjdm8HlGWc

CIR_AACR's tweet photo. Targeting #CCR4 on #Tregs affects clinical responses and survival in a spontaneous #BladderCancer #CanineModels.
#ImmuneBlockade
https://t.co/Rjdm8HlGWc https://t.co/RcCkjrmMr1

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Cellworks @CellworksLife

over 7 years ago

Long-term mogamulizumab treatment provides significant clinical benefit to patients with previously treated cutaneous T-cell lymphoma who had blood involvement at baseline, regardless of C-C chemokine receptor 4 expression status. https://t.co/6v2GwymM0t #CTCL #CCR4

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VJHemOnc

@VJHemOnc

about 8 years ago

NEWS: #FDAapproval for the #CCR4 mAb #mogamulizumab for two rare #CutaneousLymphoma types: https://t.co/VwsJH64vYK 💊 #LymSM #CTCL #TCellLymphoma #ImmunoOnc #CaxTx #DrugApproval #NonHodgkin #Lymphoma #hcsm

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Maxwell Fung, MD @FungMaxwell

over 8 years ago

HTLV-1 positive serology alone is suggestive but not diagnostic of adult T cell leukemia/lymphoma; viral integration studies not available in the US. Dr.Gru. #ISDPSanDiego #ISDP2018 #dermpath #hemepath #mogamulizumab #CCR4 #AAD18

FungMaxwell's tweet photo. HTLV-1 positive serology alone is suggestive but not diagnostic of adult T cell leukemia/lymphoma; viral integration studies not available in the US. Dr.Gru. #ISDPSanDiego #ISDP2018 #dermpath #hemepath #mogamulizumab #CCR4 #AAD18 https://t.co/Gl6p1J5RhF

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野村俊一 @mansaqu

over 8 years ago

#線維筋痛症の判定方法並びにヒトから採取した生体試料中の #MAIT細胞について #全T細胞に対するMAIT細胞の存在割合又は #CD4 #CD8 #CCR4、#CCR7 #CXCR1 #NKp80 #CD150、#CD107a #CD8β #CD44 及び #CXCR4 からなる群より選ばれる1以上の表面抗原の測定手段を含む #線維筋痛症の診断キット →続く https://t.co/1KW2SE6KJ4

野村俊一 @mansaqu

over 8 years ago

#線維筋痛症の判定方法及びキットヒトから採取した生体試料中のMAIT細胞について #全T細胞に対するMAIT細胞の存在割合又は #CD4 #CD8 #CCR4 #CCR7 #CXCR1 #NKp80、#CD150 #CD107a #CD8β #CD44、及びCXCR4からなる群より選ばれる1以上の表面抗原の発現量の測定を含む引用元 https://t.co/FSEYQ3qhlZ

mansaqu's tweet photo. #線維筋痛症の判定方法及びキット
ヒトから採取した生体試料中のMAIT細胞について #全T細胞に対するMAIT細胞の存在割合又は #CD4 #CD8 #CCR4 #CCR7 #CXCR1 #NKp80、#CD150 #CD107a #CD8β #CD44、及びCXCR4からなる群より選ばれる1以上の表面抗原の発現量の測定を含む
引用元
https://t.co/FSEYQ3qhlZ https://t.co/9TapV0jZ47

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野村俊一 @mansaqu

over 8 years ago

#線維筋痛症の判定方法及びキットヒトから採取した生体試料中のMAIT細胞について #全T細胞に対するMAIT細胞の存在割合又は #CD4 #CD8 #CCR4 #CCR7 #CXCR1 #NKp80、#CD150 #CD107a #CD8β #CD44、及びCXCR4からなる群より選ばれる1以上の表面抗原の発現量の測定を含む引用元 https://t.co/FSEYQ3qhlZ

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CancerWallonia @CancerWallonia

almost 10 years ago

#Mogamulizumab (#KW-0761) #selectively #binds to and #blocks the #activity of #CCR4

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